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Protein

Peroxisomal coenzyme A diphosphatase NUDT7

Gene

NUDT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).By similarity

Cofactori

Mn2+By similarity, Mg2+By similarity

Enzyme regulationi

Inhibited by fluoride.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921Magnesium or manganeseBy similarity
Metal bindingi96 – 961Magnesium or manganeseBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal coenzyme A diphosphatase NUDT7 (EC:3.6.1.-)
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 7
Short name:
Nudix motif 7
Gene namesi
Name:NUDT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:8054. NUDT7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31840.

Polymorphism and mutation databases

BioMutaiNUDT7.
DMDMi68565858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Peroxisomal coenzyme A diphosphatase NUDT7PRO_0000057140Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201N6-succinyllysineBy similarity

Proteomic databases

MaxQBiP0C024.
PaxDbiP0C024.
PRIDEiP0C024.

PTM databases

PhosphoSiteiP0C024.

Expressioni

Tissue specificityi

Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain.1 Publication

Gene expression databases

BgeeiP0C024.
CleanExiHS_NUDT7.
ExpressionAtlasiP0C024. baseline and differential.
GenevestigatoriP0C024.

Organism-specific databases

HPAiHPA042042.

Interactioni

Protein-protein interaction databases

BioGridi129708. 2 interactions.
STRINGi9606.ENSP00000268533.

Structurei

3D structure databases

ProteinModelPortaliP0C024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 172136Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi77 – 9822Nudix boxAdd
BLAST
Motifi236 – 2383Microbody targeting signalBy similarity

Sequence similaritiesi

Belongs to the Nudix hydrolase family. PCD1 subfamily.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0494.
GeneTreeiENSGT00530000063767.
HOGENOMiHOG000250455.
HOVERGENiHBG082067.
InParanoidiP0C024.
KOiK17879.
OMAiIKGMTAN.
OrthoDBiEOG77HDFZ.
PhylomeDBiP0C024.
TreeFamiTF106350.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR000059. NUDIX_hydrolase_NudL_CS.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS01293. NUDIX_COA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0C024-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRLGLPEEP VRNSLLDDAK ARLRKYDIGG KYSHLPYNKY SVLLPLVAKE
60 70 80 90 100
GKLHLLFTVR SEKLRRAPGE VCFPGGKRDP TDMDDAATAL REAQEEVGLR
110 120 130 140 150
PHQVEVVCCL VPCLIDTDTL ITPFVGLIDH NFQAQPNPAE VKDVFLVPLA
160 170 180 190 200
YFLHPQVHDQ HYVTRLGHRF INHIFEYTNP EDGVTYQIKG MTANLAVLVA
210 220 230
FIILEKKPTF EVQFNLNDVL ASSEELFLKV HKKATSRL
Length:238
Mass (Da):26,942
Last modified:July 5, 2005 - v1
Checksum:i6F5BE439D609DC88
GO
Isoform 2 (identifier: P0C024-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-116: Missing.

Show »
Length:185
Mass (Da):21,183
Checksum:i93D25C075BA6CAAF
GO
Isoform 3 (identifier: P0C024-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-170: TDTLITPFVG...HYVTRLGHRF → RWGSRYVDEA...PQLPGPAESC
     171-238: Missing.

Note: Gene prediction based on EST data.

Show »
Length:170
Mass (Da):18,724
Checksum:i3976BDB83FB8F09B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001R → H.
Corresponds to variant rs308925 [ dbSNP | Ensembl ].
VAR_050415
Natural varianti181 – 1811E → G.
Corresponds to variant rs16946429 [ dbSNP | Ensembl ].
VAR_050416

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei64 – 11653Missing in isoform 2. 2 PublicationsVSP_047605Add
BLAST
Alternative sequencei117 – 17054TDTLI…LGHRF → RWGSRYVDEAGLELLASSDP PTSASQSAGITDRYIDNSIC GFNRPQLPGPAESC in isoform 3. CuratedVSP_053820Add
BLAST
Alternative sequencei171 – 23868Missing in isoform 3. CuratedVSP_053821Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU981826 mRNA. Translation: ACH71652.1.
AK296963 mRNA. Translation: BAG59507.1.
AC092134 Genomic DNA. No translation available.
AC092724 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95595.1.
CCDSiCCDS42195.1. [P0C024-1]
CCDS58479.1. [P0C024-3]
CCDS58480.1. [P0C024-2]
RefSeqiNP_001099133.1. NM_001105663.2. [P0C024-1]
NP_001230586.1. NM_001243657.1. [P0C024-3]
NP_001230589.1. NM_001243660.1.
NP_001230590.1. NM_001243661.1. [P0C024-2]
UniGeneiHs.282665.

Genome annotation databases

EnsembliENST00000268533; ENSP00000268533; ENSG00000140876. [P0C024-1]
ENST00000437314; ENSP00000387707; ENSG00000140876. [P0C024-2]
ENST00000564085; ENSP00000457566; ENSG00000140876. [P0C024-3]
GeneIDi283927.
KEGGihsa:283927.
UCSCiuc010chd.3. human. [P0C024-1]
uc010vnj.2. human.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU981826 mRNA. Translation: ACH71652.1.
AK296963 mRNA. Translation: BAG59507.1.
AC092134 Genomic DNA. No translation available.
AC092724 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95595.1.
CCDSiCCDS42195.1. [P0C024-1]
CCDS58479.1. [P0C024-3]
CCDS58480.1. [P0C024-2]
RefSeqiNP_001099133.1. NM_001105663.2. [P0C024-1]
NP_001230586.1. NM_001243657.1. [P0C024-3]
NP_001230589.1. NM_001243660.1.
NP_001230590.1. NM_001243661.1. [P0C024-2]
UniGeneiHs.282665.

3D structure databases

ProteinModelPortaliP0C024.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129708. 2 interactions.
STRINGi9606.ENSP00000268533.

PTM databases

PhosphoSiteiP0C024.

Polymorphism and mutation databases

BioMutaiNUDT7.
DMDMi68565858.

Proteomic databases

MaxQBiP0C024.
PaxDbiP0C024.
PRIDEiP0C024.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268533; ENSP00000268533; ENSG00000140876. [P0C024-1]
ENST00000437314; ENSP00000387707; ENSG00000140876. [P0C024-2]
ENST00000564085; ENSP00000457566; ENSG00000140876. [P0C024-3]
GeneIDi283927.
KEGGihsa:283927.
UCSCiuc010chd.3. human. [P0C024-1]
uc010vnj.2. human.

Organism-specific databases

CTDi283927.
GeneCardsiGC16P077756.
H-InvDBHIX0038925.
HGNCiHGNC:8054. NUDT7.
HPAiHPA042042.
MIMi609231. gene.
neXtProtiNX_P0C024.
PharmGKBiPA31840.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0494.
GeneTreeiENSGT00530000063767.
HOGENOMiHOG000250455.
HOVERGENiHBG082067.
InParanoidiP0C024.
KOiK17879.
OMAiIKGMTAN.
OrthoDBiEOG77HDFZ.
PhylomeDBiP0C024.
TreeFamiTF106350.

Miscellaneous databases

ChiTaRSiNUDT7. human.
GenomeRNAii283927.
NextBioi94370.
PROiP0C024.
SOURCEiSearch...

Gene expression databases

BgeeiP0C024.
CleanExiHS_NUDT7.
ExpressionAtlasiP0C024. baseline and differential.
GenevestigatoriP0C024.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR000059. NUDIX_hydrolase_NudL_CS.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
PS01293. NUDIX_COA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcript variant 2 encodes a short isoform for Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 7 (NUDT7)."
    Hong J.
    Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Tongue.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives."
    Gasmi L., McLennan A.G.
    Biochem. J. 357:33-38(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNUDT7_HUMAN
AccessioniPrimary (citable) accession number: P0C024
Secondary accession number(s): B4DLE5, H3BUB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 27, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.