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Protein

Peroxisomal coenzyme A diphosphatase NUDT7

Gene

NUDT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity).By similarity

Cofactori

Mn2+By similarity, Mg2+By similarity

Enzyme regulationi

Inhibited by fluoride.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi92Magnesium or manganeseBy similarity1
Metal bindingi96Magnesium or manganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, RNA-binding
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-390918. Peroxisomal lipid metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal coenzyme A diphosphatase NUDT7 (EC:3.6.1.-)
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 7
Short name:
Nudix motif 7
Gene namesi
Name:NUDT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140876.11.
HGNCiHGNC:8054. NUDT7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi283927.
OpenTargetsiENSG00000140876.
PharmGKBiPA31840.

Polymorphism and mutation databases

BioMutaiNUDT7.
DMDMi68565858.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000571401 – 238Peroxisomal coenzyme A diphosphatase NUDT7Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20N6-succinyllysineBy similarity1

Proteomic databases

EPDiP0C024.
MaxQBiP0C024.
PaxDbiP0C024.
PeptideAtlasiP0C024.
PRIDEiP0C024.

PTM databases

iPTMnetiP0C024.
PhosphoSitePlusiP0C024.

Expressioni

Tissue specificityi

Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000140876.
CleanExiHS_NUDT7.
ExpressionAtlasiP0C024. baseline and differential.
GenevisibleiP0C024. HS.

Organism-specific databases

HPAiHPA042042.

Interactioni

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi129708. 2 interactors.
STRINGi9606.ENSP00000268533.

Structurei

Secondary structure

1238
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi15 – 23Combined sources9
Helixi24 – 26Combined sources3
Turni29 – 32Combined sources4
Beta strandi36 – 49Combined sources14
Beta strandi52 – 60Combined sources9
Beta strandi64 – 67Combined sources4
Beta strandi74 – 77Combined sources4
Helixi85 – 97Combined sources13
Helixi101 – 103Combined sources3
Beta strandi104 – 109Combined sources6
Beta strandi113 – 128Combined sources16
Turni138 – 140Combined sources3
Beta strandi141 – 148Combined sources8
Helixi149 – 152Combined sources4
Beta strandi156 – 164Combined sources9
Beta strandi166 – 178Combined sources13
Turni180 – 182Combined sources3
Beta strandi185 – 189Combined sources5
Helixi190 – 204Combined sources15
Helixi219 – 228Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5T3PX-ray2.03A/B/C1-235[»]
ProteinModelPortaliP0C024.
SMRiP0C024.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 172Nudix hydrolasePROSITE-ProRule annotationAdd BLAST136

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi77 – 98Nudix boxAdd BLAST22
Motifi236 – 238Microbody targeting signalBy similarity3

Sequence similaritiesi

Belongs to the Nudix hydrolase family. PCD1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3069. Eukaryota.
COG0494. LUCA.
GeneTreeiENSGT00530000063767.
HOGENOMiHOG000250455.
HOVERGENiHBG082067.
InParanoidiP0C024.
KOiK17879.
OMAiVICRLVP.
OrthoDBiEOG091G0QFW.
PhylomeDBiP0C024.
TreeFamiTF106350.

Family and domain databases

InterProiView protein in InterPro
IPR015797. NUDIX_hydrolase-like_dom_sf.
IPR000086. NUDIX_hydrolase_dom.
IPR000059. NUDIX_hydrolase_NudL_CS.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.
PS01293. NUDIX_COA. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0C024-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRLGLPEEP VRNSLLDDAK ARLRKYDIGG KYSHLPYNKY SVLLPLVAKE
60 70 80 90 100
GKLHLLFTVR SEKLRRAPGE VCFPGGKRDP TDMDDAATAL REAQEEVGLR
110 120 130 140 150
PHQVEVVCCL VPCLIDTDTL ITPFVGLIDH NFQAQPNPAE VKDVFLVPLA
160 170 180 190 200
YFLHPQVHDQ HYVTRLGHRF INHIFEYTNP EDGVTYQIKG MTANLAVLVA
210 220 230
FIILEKKPTF EVQFNLNDVL ASSEELFLKV HKKATSRL
Length:238
Mass (Da):26,942
Last modified:July 5, 2005 - v1
Checksum:i6F5BE439D609DC88
GO
Isoform 2 (identifier: P0C024-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-116: Missing.

Show »
Length:185
Mass (Da):21,183
Checksum:i93D25C075BA6CAAF
GO
Isoform 3 (identifier: P0C024-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-170: TDTLITPFVG...HYVTRLGHRF → RWGSRYVDEA...PQLPGPAESC
     171-238: Missing.

Note: Gene prediction based on EST data.
Show »
Length:170
Mass (Da):18,724
Checksum:i3976BDB83FB8F09B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050415100R → H. Corresponds to variant dbSNP:rs308925Ensembl.1
Natural variantiVAR_050416181E → G. Corresponds to variant dbSNP:rs16946429Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04760564 – 116Missing in isoform 2. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_053820117 – 170TDTLI…LGHRF → RWGSRYVDEAGLELLASSDP PTSASQSAGITDRYIDNSIC GFNRPQLPGPAESC in isoform 3. CuratedAdd BLAST54
Alternative sequenceiVSP_053821171 – 238Missing in isoform 3. CuratedAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU981826 mRNA. Translation: ACH71652.1.
AK296963 mRNA. Translation: BAG59507.1.
AC092134 Genomic DNA. No translation available.
AC092724 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95595.1.
CCDSiCCDS42195.1. [P0C024-1]
CCDS58479.1. [P0C024-3]
CCDS58480.1. [P0C024-2]
RefSeqiNP_001099133.1. NM_001105663.2. [P0C024-1]
NP_001230586.1. NM_001243657.1. [P0C024-3]
NP_001230589.1. NM_001243660.1.
NP_001230590.1. NM_001243661.1. [P0C024-2]
UniGeneiHs.282665.

Genome annotation databases

EnsembliENST00000268533; ENSP00000268533; ENSG00000140876. [P0C024-1]
ENST00000437314; ENSP00000387707; ENSG00000140876. [P0C024-2]
ENST00000564085; ENSP00000457566; ENSG00000140876. [P0C024-3]
GeneIDi283927.
KEGGihsa:283927.
UCSCiuc010chd.4. human. [P0C024-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNUDT7_HUMAN
AccessioniPrimary (citable) accession number: P0C024
Secondary accession number(s): B4DLE5, H3BUB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 22, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries