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P0C024 (NUDT7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal coenzyme A diphosphatase NUDT7

EC=3.6.1.-
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 7
Short name=Nudix motif 7
Gene names
Name:NUDT7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA By similarity.

Cofactor

Manganese or magnesium By similarity.

Enzyme regulation

Inhibited by fluoride By similarity.

Subcellular location

Peroxisome By similarity.

Tissue specificity

Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain. Ref.5

Sequence similarities

Belongs to the Nudix hydrolase family. PCD1 subfamily.

Contains 1 nudix hydrolase domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P0C024-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P0C024-2)

The sequence of this isoform differs from the canonical sequence as follows:
     64-116: Missing.
Isoform 3 (identifier: P0C024-3)

The sequence of this isoform differs from the canonical sequence as follows:
     117-170: TDTLITPFVG...HYVTRLGHRF → RWGSRYVDEA...PQLPGPAESC
     171-238: Missing.
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238Peroxisomal coenzyme A diphosphatase NUDT7
PRO_0000057140

Regions

Domain37 – 172136Nudix hydrolase
Motif77 – 9822Nudix box
Motif236 – 2383Microbody targeting signal By similarity

Sites

Metal binding921Magnesium or manganese By similarity
Metal binding961Magnesium or manganese By similarity

Amino acid modifications

Modified residue201N6-succinyllysine By similarity

Natural variations

Alternative sequence64 – 11653Missing in isoform 2.
VSP_047605
Alternative sequence117 – 17054TDTLI…LGHRF → RWGSRYVDEAGLELLASSDP PTSASQSAGITDRYIDNSIC GFNRPQLPGPAESC in isoform 3.
VSP_053820
Alternative sequence171 – 23868Missing in isoform 3.
VSP_053821
Natural variant1001R → H.
Corresponds to variant rs308925 [ dbSNP | Ensembl ].
VAR_050415
Natural variant1811E → G.
Corresponds to variant rs16946429 [ dbSNP | Ensembl ].
VAR_050416

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2005. Version 1.
Checksum: 6F5BE439D609DC88

FASTA23826,942
        10         20         30         40         50         60 
MSRLGLPEEP VRNSLLDDAK ARLRKYDIGG KYSHLPYNKY SVLLPLVAKE GKLHLLFTVR 

        70         80         90        100        110        120 
SEKLRRAPGE VCFPGGKRDP TDMDDAATAL REAQEEVGLR PHQVEVVCCL VPCLIDTDTL 

       130        140        150        160        170        180 
ITPFVGLIDH NFQAQPNPAE VKDVFLVPLA YFLHPQVHDQ HYVTRLGHRF INHIFEYTNP 

       190        200        210        220        230 
EDGVTYQIKG MTANLAVLVA FIILEKKPTF EVQFNLNDVL ASSEELFLKV HKKATSRL 

« Hide

Isoform 2 [UniParc].

Checksum: 93D25C075BA6CAAF
Show »

FASTA18521,183
Isoform 3 [UniParc].

Checksum: 3976BDB83FB8F09B
Show »

FASTA17018,724

References

« Hide 'large scale' references
[1]"The transcript variant 2 encodes a short isoform for Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 7 (NUDT7)."
Hong J.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Tongue.
[3]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives."
Gasmi L., McLennan A.G.
Biochem. J. 357:33-38(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU981826 mRNA. Translation: ACH71652.1.
AK296963 mRNA. Translation: BAG59507.1.
AC092134 Genomic DNA. No translation available.
AC092724 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95595.1.
RefSeqNP_001099133.1. NM_001105663.2.
NP_001230586.1. NM_001243657.1.
NP_001230589.1. NM_001243660.1.
NP_001230590.1. NM_001243661.1.
UniGeneHs.282665.

3D structure databases

ProteinModelPortalP0C024.
SMRP0C024. Positions 36-200.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129708. 3 interactions.
STRING9606.ENSP00000268533.

PTM databases

PhosphoSiteP0C024.

Polymorphism databases

DMDM68565858.

Proteomic databases

PaxDbP0C024.
PRIDEP0C024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000268533; ENSP00000268533; ENSG00000140876. [P0C024-1]
ENST00000437314; ENSP00000387707; ENSG00000140876. [P0C024-2]
ENST00000564085; ENSP00000457566; ENSG00000140876.
GeneID283927.
KEGGhsa:283927.
UCSCuc010chd.3. human. [P0C024-1]

Organism-specific databases

CTD283927.
GeneCardsGC16P077756.
H-InvDBHIX0038925.
HGNCHGNC:8054. NUDT7.
HPAHPA042042.
MIM609231. gene.
neXtProtNX_P0C024.
PharmGKBPA31840.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0494.
HOGENOMHOG000250455.
HOVERGENHBG082067.
InParanoidP0C024.
KOK17879.
OMAIKGMTAN.
PhylomeDBP0C024.
TreeFamTF106350.

Gene expression databases

ArrayExpressP0C024.
BgeeP0C024.
CleanExHS_NUDT7.
GenevestigatorP0C024.

Family and domain databases

Gene3D3.90.79.10. 1 hit.
InterProIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR000059. NUDIX_hydrolase_NudL_CS.
[Graphical view]
PfamPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMSSF55811. SSF55811. 1 hit.
PROSITEPS51462. NUDIX. 1 hit.
PS01293. NUDIX_COA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi283927.
NextBio94370.
PROP0C024.
SOURCESearch...

Entry information

Entry nameNUDT7_HUMAN
AccessionPrimary (citable) accession number: P0C024
Secondary accession number(s): B4DLE5, H3BUB8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM