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P0C024

- NUDT7_HUMAN

UniProt

P0C024 - NUDT7_HUMAN

Protein

Peroxisomal coenzyme A diphosphatase NUDT7

Gene

NUDT7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA By similarity.By similarity

    Cofactori

    Manganese or magnesium.By similarity

    Enzyme regulationi

    Inhibited by fluoride.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi92 – 921Magnesium or manganeseBy similarity
    Metal bindingi96 – 961Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. acetyl-CoA hydrolase activity Source: UniProtKB
    2. hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Source: InterPro
    3. magnesium ion binding Source: InterPro
    4. manganese ion binding Source: InterPro
    5. receptor binding Source: UniProtKB
    6. snoRNA binding Source: UniProtKB

    GO - Biological processi

    1. acetyl-CoA catabolic process Source: UniProtKB
    2. brown fat cell differentiation Source: Ensembl
    3. coenzyme A catabolic process Source: UniProtKB
    4. nucleoside diphosphate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal coenzyme A diphosphatase NUDT7 (EC:3.6.1.-)
    Alternative name(s):
    Nucleoside diphosphate-linked moiety X motif 7
    Short name:
    Nudix motif 7
    Gene namesi
    Name:NUDT7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:8054. NUDT7.

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Peroxisome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31840.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238Peroxisomal coenzyme A diphosphatase NUDT7PRO_0000057140Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201N6-succinyllysineBy similarity

    Proteomic databases

    MaxQBiP0C024.
    PaxDbiP0C024.
    PRIDEiP0C024.

    PTM databases

    PhosphoSiteiP0C024.

    Expressioni

    Tissue specificityi

    Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain.1 Publication

    Gene expression databases

    ArrayExpressiP0C024.
    BgeeiP0C024.
    CleanExiHS_NUDT7.
    GenevestigatoriP0C024.

    Organism-specific databases

    HPAiHPA042042.

    Interactioni

    Protein-protein interaction databases

    BioGridi129708. 3 interactions.
    STRINGi9606.ENSP00000268533.

    Structurei

    3D structure databases

    ProteinModelPortaliP0C024.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 172136Nudix hydrolasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi77 – 9822Nudix boxAdd
    BLAST
    Motifi236 – 2383Microbody targeting signalBy similarity

    Sequence similaritiesi

    Belongs to the Nudix hydrolase family. PCD1 subfamily.Curated
    Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0494.
    HOGENOMiHOG000250455.
    HOVERGENiHBG082067.
    InParanoidiP0C024.
    KOiK17879.
    OMAiMRANCAM.
    PhylomeDBiP0C024.
    TreeFamiTF106350.

    Family and domain databases

    Gene3Di3.90.79.10. 1 hit.
    InterProiIPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR000059. NUDIX_hydrolase_NudL_CS.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    [Graphical view]
    SUPFAMiSSF55811. SSF55811. 1 hit.
    PROSITEiPS51462. NUDIX. 1 hit.
    PS01293. NUDIX_COA. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P0C024-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRLGLPEEP VRNSLLDDAK ARLRKYDIGG KYSHLPYNKY SVLLPLVAKE    50
    GKLHLLFTVR SEKLRRAPGE VCFPGGKRDP TDMDDAATAL REAQEEVGLR 100
    PHQVEVVCCL VPCLIDTDTL ITPFVGLIDH NFQAQPNPAE VKDVFLVPLA 150
    YFLHPQVHDQ HYVTRLGHRF INHIFEYTNP EDGVTYQIKG MTANLAVLVA 200
    FIILEKKPTF EVQFNLNDVL ASSEELFLKV HKKATSRL 238
    Length:238
    Mass (Da):26,942
    Last modified:July 5, 2005 - v1
    Checksum:i6F5BE439D609DC88
    GO
    Isoform 2 (identifier: P0C024-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         64-116: Missing.

    Show »
    Length:185
    Mass (Da):21,183
    Checksum:i93D25C075BA6CAAF
    GO
    Isoform 3 (identifier: P0C024-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         117-170: TDTLITPFVG...HYVTRLGHRF → RWGSRYVDEA...PQLPGPAESC
         171-238: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:170
    Mass (Da):18,724
    Checksum:i3976BDB83FB8F09B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti100 – 1001R → H.
    Corresponds to variant rs308925 [ dbSNP | Ensembl ].
    VAR_050415
    Natural varianti181 – 1811E → G.
    Corresponds to variant rs16946429 [ dbSNP | Ensembl ].
    VAR_050416

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei64 – 11653Missing in isoform 2. 2 PublicationsVSP_047605Add
    BLAST
    Alternative sequencei117 – 17054TDTLI…LGHRF → RWGSRYVDEAGLELLASSDP PTSASQSAGITDRYIDNSIC GFNRPQLPGPAESC in isoform 3. CuratedVSP_053820Add
    BLAST
    Alternative sequencei171 – 23868Missing in isoform 3. CuratedVSP_053821Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU981826 mRNA. Translation: ACH71652.1.
    AK296963 mRNA. Translation: BAG59507.1.
    AC092134 Genomic DNA. No translation available.
    AC092724 Genomic DNA. No translation available.
    CH471114 Genomic DNA. Translation: EAW95595.1.
    CCDSiCCDS42195.1. [P0C024-1]
    CCDS58479.1. [P0C024-3]
    CCDS58480.1. [P0C024-2]
    RefSeqiNP_001099133.1. NM_001105663.2. [P0C024-1]
    NP_001230586.1. NM_001243657.1. [P0C024-3]
    NP_001230589.1. NM_001243660.1.
    NP_001230590.1. NM_001243661.1. [P0C024-2]
    UniGeneiHs.282665.

    Genome annotation databases

    EnsembliENST00000268533; ENSP00000268533; ENSG00000140876. [P0C024-1]
    ENST00000437314; ENSP00000387707; ENSG00000140876. [P0C024-2]
    ENST00000564085; ENSP00000457566; ENSG00000140876. [P0C024-3]
    GeneIDi283927.
    KEGGihsa:283927.
    UCSCiuc010chd.3. human. [P0C024-1]
    uc010vnj.2. human.

    Polymorphism databases

    DMDMi68565858.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU981826 mRNA. Translation: ACH71652.1 .
    AK296963 mRNA. Translation: BAG59507.1 .
    AC092134 Genomic DNA. No translation available.
    AC092724 Genomic DNA. No translation available.
    CH471114 Genomic DNA. Translation: EAW95595.1 .
    CCDSi CCDS42195.1. [P0C024-1 ]
    CCDS58479.1. [P0C024-3 ]
    CCDS58480.1. [P0C024-2 ]
    RefSeqi NP_001099133.1. NM_001105663.2. [P0C024-1 ]
    NP_001230586.1. NM_001243657.1. [P0C024-3 ]
    NP_001230589.1. NM_001243660.1.
    NP_001230590.1. NM_001243661.1. [P0C024-2 ]
    UniGenei Hs.282665.

    3D structure databases

    ProteinModelPortali P0C024.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129708. 3 interactions.
    STRINGi 9606.ENSP00000268533.

    PTM databases

    PhosphoSitei P0C024.

    Polymorphism databases

    DMDMi 68565858.

    Proteomic databases

    MaxQBi P0C024.
    PaxDbi P0C024.
    PRIDEi P0C024.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268533 ; ENSP00000268533 ; ENSG00000140876 . [P0C024-1 ]
    ENST00000437314 ; ENSP00000387707 ; ENSG00000140876 . [P0C024-2 ]
    ENST00000564085 ; ENSP00000457566 ; ENSG00000140876 . [P0C024-3 ]
    GeneIDi 283927.
    KEGGi hsa:283927.
    UCSCi uc010chd.3. human. [P0C024-1 ]
    uc010vnj.2. human.

    Organism-specific databases

    CTDi 283927.
    GeneCardsi GC16P077756.
    H-InvDB HIX0038925.
    HGNCi HGNC:8054. NUDT7.
    HPAi HPA042042.
    MIMi 609231. gene.
    neXtProti NX_P0C024.
    PharmGKBi PA31840.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0494.
    HOGENOMi HOG000250455.
    HOVERGENi HBG082067.
    InParanoidi P0C024.
    KOi K17879.
    OMAi MRANCAM.
    PhylomeDBi P0C024.
    TreeFami TF106350.

    Miscellaneous databases

    GenomeRNAii 283927.
    NextBioi 94370.
    PROi P0C024.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P0C024.
    Bgeei P0C024.
    CleanExi HS_NUDT7.
    Genevestigatori P0C024.

    Family and domain databases

    Gene3Di 3.90.79.10. 1 hit.
    InterProi IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR000059. NUDIX_hydrolase_NudL_CS.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55811. SSF55811. 1 hit.
    PROSITEi PS51462. NUDIX. 1 hit.
    PS01293. NUDIX_COA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcript variant 2 encodes a short isoform for Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 7 (NUDT7)."
      Hong J.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Tongue.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives."
      Gasmi L., McLennan A.G.
      Biochem. J. 357:33-38(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNUDT7_HUMAN
    AccessioniPrimary (citable) accession number: P0C024
    Secondary accession number(s): B4DLE5, H3BUB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families
    6. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3