Reviewed, UniProtKB/Swiss-Prot P0C017 (PUR6_CRYNV)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:

ADE2

Organism

Cryptococcus neoformans var. grubii (Filobasidiella neoformans var. grubii)

Taxonomic identifier

178876 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length	582 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Sequence similarities	In the C-terminal section; belongs to the AIR carboxylase family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 582	582	Phosphoribosylaminoimidazole carboxylase		PRO_0000075024
Regions
	Domain	114 – 305	192	ATP-grasp
	Nucleotide binding	143 – 200	58	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0C017-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 2AC692442FAF1F7D	FASTA	582	62,429
	10 20 30 40 50 60 MAPRKTVGIL GGGQLGRMLT HPAALLGIPL LILDSGSFTP AKQTLLPPPS HSHPDGPFTS 70 80 90 100 110 120 EPHIRKLASA CDILTVEIEH VNADVLEAVE KEGLCEVQPS PKTIRLIQNK YDQKKYLAEK 130 140 150 160 170 180 GVAVAPFEEL PANPTEEDFK AIAGRLGLPL MLKAKTLAYD GRGNSPLKST SSEDIQASLK 190 200 210 220 230 240 FLGDRPLYAE GWAPFVKEVA VMVVRNKEGE VQSYDAVETI HRESILRVCL APLRGERGVN 250 260 270 280 290 300 QRARELAEKA VGHLEGAGIF GVEMFLMPDG ELLLNEIAPR PHNSGHHTIE ACLTSQFENH 310 320 330 340 350 360 LRAILSLPLG STALRVPSAA MVNILGASST MDAIDKMADN ALTVPGAAVH LYGKAESRKA 370 380 390 400 410 420 RKMGHITVTA ESDAELNERL RTLLFAQPDA HADWIDLIAP PSPAPAHSHP KPLVGIIMGS 430 440 450 460 470 480 DSDLPVMHPA TKILEKFGVP YELTITSAHR TPERMVKYAK TAAGRGLRAI IAGAGGAAHL 490 500 510 520 530 540 PGMVASETSL PVIGVPVKAS VLDGVDSLYS IVQMPRGIPC ATVGINNSTN AALLAIRILG 550 560 570 580 TSVPALNKAT EEYSKALEEE VLAKVDILEE EGWDKYIERL KK

References

[1]	Perfect J.R. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: H99.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U70673 mRNA. Translation: AAB09711.1. Different initiation.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.1.21. 303268.
Family and domain databases
InterPro	IPR016301. AIR_COase. IPR005875. AIR_COase_ATPase-su. IPR000031. AIR_COase_core. IPR011761. ATP-grasp. IPR003135. ATP-grasp_carboxylate-amine. IPR013816. ATP_grasp_subdomain_2. IPR013817. Pre-ATP_grasp. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit. G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
PANTHER	PTHR23047:SF1. PurK_ATP. 1 hit.
Pfam	PF00731. AIRC. 1 hit. PF02222. ATP-grasp. 1 hit. [Graphical view]
PIRSF	PIRSF001340. AIR_carboxylase. 1 hit.
ProDom	PD002193. AIR_carboxyl. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01162. purE. 1 hit. TIGR01161. purK. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR6_CRYNV

Accession

Primary (citable) accession number: P0C017
Secondary accession number(s): O93936, Q92233

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	September 1, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)