SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0C004

- DHP1_CORGT

UniProt

P0C004 - DHP1_CORGT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dihydropteroate synthase type-1

Gene
sulI
Organism
Corynebacterium glutamicum (Brevibacterium saccharolyticum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. Implicated in resistance to sulfonamide. The type II enzyme is stable whereas type I DHPS loses its activity rapidly By similarity.

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Magnesium By similarity
Binding sitei17 – 171Substrate By similarity
Binding sitei82 – 821Substrate By similarity
Binding sitei101 – 1011Substrate By similarity
Binding sitei173 – 1731Substrate By similarity
Binding sitei212 – 2121Substrate By similarity
Binding sitei246 – 2461Substrate By similarity
Binding sitei248 – 2481Substrate By similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase type-1 (EC:2.5.1.15)
Alternative name(s):
Dihydropteroate pyrophosphorylase type I
Dihydropteroate synthase type I
Short name:
DHPS
Gene namesi
Name:sulI
Encoded oniPlasmid pCG41 Publication
OrganismiCorynebacterium glutamicum (Brevibacterium saccharolyticum)
Taxonomic identifieri1718 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 279279Dihydropteroate synthase type-1PRO_0000168200Add
BLAST

Interactioni

Subunit structurei

Homodimer or homotrimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP0C004.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 258258Pterin-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 502Substrate binding By similarity

Sequence similaritiesi

Belongs to the DHPS family.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0C004-1 [UniParc]FASTAAdd to Basket

« Hide

MVTVFGILNL TEDSFFDESR RLDPAGAVTA AIEMLRVGSD VVDVGPAASH    50
PDARPVSPAD EIRRIAPLLD ALSDQMHRVS IDSFQPETQR YALKRGVGYL 100
NDIQGFPDPA LYPDIAEADC RLVVMHSAQR DGIATRTGHL RPEDALDEIV 150
RFFEARVSAL RRSGVAADRL ILDPGMGFFL SPAPETSLHV LSNLQKLKSA 200
LGLPLLVSVS RKSFLGATVG LPVKDLGPAS LAAELHAIGN GADYVRTHAP 250
GDLRSAITFS ETLAKFRSRD ARDRGLDHA 279
Length:279
Mass (Da):30,126
Last modified:June 7, 2005 - v1
Checksum:i13EE36C6E3FBDF63
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14748 Genomic DNA. Translation: CAA75045.1.
RefSeqiNP_478074.1. NC_003227.1.
NP_862308.1. NC_004945.1.

Genome annotation databases

GeneIDi1132010.
1450507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14748 Genomic DNA. Translation: CAA75045.1 .
RefSeqi NP_478074.1. NC_003227.1.
NP_862308.1. NC_004945.1.

3D structure databases

ProteinModelPortali P0C004.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1132010.
1450507.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An integron of class 1 is present on the plasmid pCG4 from Gram-positive bacterium Corynebacterium glutamicum."
    Nesvera J., Hochmannova J., Patek M.
    FEMS Microbiol. Lett. 169:391-395(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 31830 / T250.
    Plasmid: pCG4

Entry informationi

Entry nameiDHP1_CORGT
AccessioniPrimary (citable) accession number: P0C004
Secondary accession number(s): P11744, Q93K51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The sulI gene is located on various large self-transmissible resistance plasmids and on transposons related to Tn21.

Keywords - Technical termi

Plasmid, Transposable element

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi