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Protein

Dihydropteroate synthase type-1

Gene

sulI

Organism
Pseudomonas aeruginosa
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.By similarity

Miscellaneous

The sulI gene is located on various large self-transmissible resistance plasmids and on transposons related to Tn21.

Catalytic activityi

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (folP_1), Dihydropteroate synthase, Dihydropteroate synthase (folP), Dihydropteroate synthase (sul1), Dihydropteroate synthase (sul1), Dihydropteroate synthase, Dihydropteroate synthase (sul3), Dihydropteroate synthase (folP), Dihydropteroate synthase (sulIdelta), Dihydropteroate synthase (sulI), Dihydropteroate synthase (sul2), Dihydropteroate synthase (sul1), Dihydropteroate synthase (sul1), Dihydropteroate synthase (folP), Dihydropteroate synthase type-1 (sulI), Dihydropteroate synthase (sul1), Dihydropteroate synthase, Dihydropteroate synthase (sul1), Dihydropteroate synthase (sul1), Dihydropteroate synthase (sul1), Dihydropteroate synthase (folP_1), Dihydropteroate synthase (sul3)
  2. no protein annotated in this organism
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumBy similarity1
Binding sitei826-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1016-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1736-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2126-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFolate biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase type-1 (EC:2.5.1.15)
Alternative name(s):
Dihydropteroate pyrophosphorylase type I
Dihydropteroate synthase type I
Short name:
DHPS
Gene namesi
Name:sulI
Encoded oniPlasmid pVS11 Publication
OrganismiPseudomonas aeruginosa
Taxonomic identifieri287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682021 – 279Dihydropteroate synthase type-1Add BLAST279

Interactioni

Subunit structurei

Homodimer or homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0C003
SMRiP0C003
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 258Pterin-bindingPROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni246 – 2486-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

Belongs to the DHPS family.Curated

Family and domain databases

CDDicd00739 DHPS, 1 hit
Gene3Di3.20.20.20, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P0C003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVFGILNL TEDSFFDESR RLDPAGAVTA AIEMLRVGSD VVDVGPAASH
60 70 80 90 100
PDARPVSPAD EIRRIAPLLD ALSDQMHRVS IDSFQPETQR YALKRGVGYL
110 120 130 140 150
NDIQGFPDPA LYPDIAEADC RLVVMHSAQR DGIATRTGHL RPEDALDEIV
160 170 180 190 200
RFFEARVSAL RRSGVAADRL ILDPGMGFFL SPAPETSLHV LSNLQKLKSA
210 220 230 240 250
LGLPLLVSVS RKSFLGATVG LPVKDLGPAS LAAELHAIGN GADYVRTHAP
260 270
GDLRSAITFS ETLAKFRSRD ARDRGLDHA
Length:279
Mass (Da):30,126
Last modified:June 7, 2005 - v1
Checksum:i13EE36C6E3FBDF63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49101 Genomic DNA Translation: AAC44317.1
M73819 Genomic DNA Translation: AAA25859.1
PIRiC42646
RefSeqiWP_000259031.1, NZ_PQGF01000113.1
YP_245438.1, NC_007100.1

Genome annotation databases

GeneIDi3399458
4999104

Similar proteinsi

Entry informationi

Entry nameiDHP1_PSEAI
AccessioniPrimary (citable) accession number: P0C003
Secondary accession number(s): P11744, Q93K51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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