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Protein

Xanthine permease XanP

Gene

xanP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Specific, proton motive force-dependent high-affinity transporter for xanthine.1 Publication

Enzyme regulationi

Inhibited by CCCP and N-ethylmaleimide.1 Publication

Kineticsi

  1. KM=2.9 µM for xanthine1 Publication
  1. Vmax=0.59 nmol/min/mg enzyme1 Publication

GO - Molecular functioni

  • xanthine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • xanthine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YICE-MONOMER.
ECOL316407:JW3629-MONOMER.
MetaCyc:YICE-MONOMER.

Protein family/group databases

TCDBi2.A.40.4.2. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine permease XanP
Gene namesi
Name:xanP
Synonyms:yicE
Ordered Locus Names:b3654, JW3629
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11194. xanP.

Subcellular locationi

  • Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Transmembranei260 – 28021HelicalSequence analysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence analysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence analysisAdd
BLAST
Transmembranei409 – 42921HelicalSequence analysisAdd
BLAST
Transmembranei439 – 45921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Xanthine permease XanPPRO_0000165969Add
BLAST

Proteomic databases

PaxDbiP0AGM9.

Interactioni

Protein-protein interaction databases

BioGridi4262570. 7 interactions.
STRINGi511145.b3654.

Structurei

3D structure databases

ProteinModelPortaliP0AGM9.
SMRiP0AGM9. Positions 26-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C2W. Bacteria.
COG2233. LUCA.
HOGENOMiHOG000038198.
InParanoidiP0AGM9.
KOiK16345.
OMAiCALVLNW.
OrthoDBiEOG6M6JJK.
PhylomeDBiP0AGM9.

Family and domain databases

InterProiIPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00801. ncs2. 1 hit.
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AGM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSTLESEN AQPVAQTQNS ELIYRLEDRP PLPQTLFAAC QHLLAMFVAV
60 70 80 90 100
ITPALLICQA LGLPAQDTQH IISMSLFASG VASIIQIKAW GPVGSGLLSI
110 120 130 140 150
QGTSFNFVAP LIMGGTALKT GGADVPTMMA ALFGTLMLAS CTEMVISRVL
160 170 180 190 200
HLARRIITPL VSGVVVMIIG LSLIQVGLTS IGGGYAAMSD NTFGAPKNLL
210 220 230 240 250
LAGVVLALII LLNRQRNPYL RVASLVIAMA AGYALAWFMG MLPESNEPMT
260 270 280 290 300
QELIMVPTPL YYGLGIEWSL LLPLMLVFMI TSLETIGDIT ATSDVSEQPV
310 320 330 340 350
SGPLYMKRLK GGVLANGLNS FVSAVFNTFP NSCFGQNNGV IQLTGVASRY
360 370 380 390 400
VGFVVALMLI VLGLFPAVSG FVQHIPEPVL GGATLVMFGT IAASGVRIVS
410 420 430 440 450
REPLNRRAIL IIALSLAVGL GVSQQPLILQ FAPEWLKNLL SSGIAAGGIT
460
AIVLNLIFPP EKQ
Length:463
Mass (Da):48,868
Last modified:December 20, 2005 - v1
Checksum:i868718559103456E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62007.1.
U00096 Genomic DNA. Translation: AAC76678.1.
AP009048 Genomic DNA. Translation: BAE77639.1.
X17499 Genomic DNA. No translation available.
PIRiH65166.
RefSeqiNP_418111.1. NC_000913.3.
WP_001295238.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76678; AAC76678; b3654.
BAE77639; BAE77639; BAE77639.
GeneIDi948172.
KEGGiecj:JW3629.
eco:b3654.
PATRICi32122795. VBIEscCol129921_3774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10328 Genomic DNA. Translation: AAA62007.1.
U00096 Genomic DNA. Translation: AAC76678.1.
AP009048 Genomic DNA. Translation: BAE77639.1.
X17499 Genomic DNA. No translation available.
PIRiH65166.
RefSeqiNP_418111.1. NC_000913.3.
WP_001295238.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AGM9.
SMRiP0AGM9. Positions 26-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262570. 7 interactions.
STRINGi511145.b3654.

Protein family/group databases

TCDBi2.A.40.4.2. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.

Proteomic databases

PaxDbiP0AGM9.

Protocols and materials databases

DNASUi948172.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76678; AAC76678; b3654.
BAE77639; BAE77639; BAE77639.
GeneIDi948172.
KEGGiecj:JW3629.
eco:b3654.
PATRICi32122795. VBIEscCol129921_3774.

Organism-specific databases

EchoBASEiEB1180.
EcoGeneiEG11194. xanP.

Phylogenomic databases

eggNOGiENOG4105C2W. Bacteria.
COG2233. LUCA.
HOGENOMiHOG000038198.
InParanoidiP0AGM9.
KOiK16345.
OMAiCALVLNW.
OrthoDBiEOG6M6JJK.
PhylomeDBiP0AGM9.

Enzyme and pathway databases

BioCyciEcoCyc:YICE-MONOMER.
ECOL316407:JW3629-MONOMER.
MetaCyc:YICE-MONOMER.

Miscellaneous databases

PROiP0AGM9.

Family and domain databases

InterProiIPR006042. Xan_ur_permease.
IPR006043. Xant/urac/vitC.
[Graphical view]
PANTHERiPTHR11119. PTHR11119. 1 hit.
PfamiPF00860. Xan_ur_permease. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00801. ncs2. 1 hit.
PROSITEiPS01116. XANTH_URACIL_PERMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication."
    Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.
    Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Characterization of the Escherichia coli K12 gltS glutamate permease gene."
    Kalman M., Gentry D., Cashel M.
    Mol. Gen. Genet. 225:379-386(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
    Strain: K12.
  5. "Cloning and functional characterization of two bacterial members of the NAT/NCS2 family in Escherichia coli."
    Karatza P., Frillingos S.
    Mol. Membr. Biol. 22:251-261(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION.
    Strain: K12.

Entry informationi

Entry nameiXANP_ECOLI
AccessioniPrimary (citable) accession number: P0AGM9
Secondary accession number(s): P27432, Q2M7W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 20, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.