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Protein

UPF0118 inner membrane protein YhhT

Gene

yhhT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:EG12220-MONOMER.
ECOL316407:JW5680-MONOMER.

Protein family/group databases

TCDBi2.A.86.1.2. the autoinducer-2 exporter (ai-2e) family (formerly the perm family, tc #9.b.22).

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0118 inner membrane protein YhhT
Gene namesi
Name:yhhT
Ordered Locus Names:b3474, JW5680
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12220. yhhT.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121HelicalSequence analysisAdd
BLAST
Topological domaini32 – 321PeriplasmicSequence analysis
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Topological domaini54 – 629CytoplasmicSequence analysis
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Topological domaini84 – 14259PeriplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence analysisAdd
BLAST
Topological domaini164 – 20845CytoplasmicSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Topological domaini230 – 2345PeriplasmicSequence analysis
Transmembranei235 – 25521HelicalSequence analysisAdd
BLAST
Topological domaini256 – 2572CytoplasmicSequence analysis
Transmembranei258 – 27821HelicalSequence analysisAdd
BLAST
Topological domaini279 – 29214PeriplasmicSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Topological domaini314 – 34936CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349UPF0118 inner membrane protein YhhTPRO_0000148301Add
BLAST

Proteomic databases

PaxDbiP0AGM0.

Interactioni

Protein-protein interaction databases

BioGridi4262490. 7 interactions.
STRINGi511145.b3474.

Structurei

3D structure databases

ProteinModelPortaliP0AGM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0118 (PerM) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DSF. Bacteria.
COG0628. LUCA.
HOGENOMiHOG000290196.
InParanoidiP0AGM0.
OMAiIDNIPRY.
OrthoDBiEOG6VTK3P.
PhylomeDBiP0AGM0.

Family and domain databases

InterProiIPR002549. AI-2E-like.
[Graphical view]
PANTHERiPTHR21716. PTHR21716. 1 hit.
PfamiPF01594. UPF0118. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AGM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPQPDKTG MHILLKLASL VVILAGIHAA ADIIVQLLLA LFFAIVLNPL
60 70 80 90 100
VTWFIRRGVQ RPVAITIVVV VMLIALTALV GVLAASFNEF ISMLPKFNKE
110 120 130 140 150
LTRKLFKLQE MLPFLNLHMS PERMLQRMDS EKVVTFTTAL MTGLSGAMAS
160 170 180 190 200
VLLLVMTVVF MLFEVRHVPY KMRFALNNPQ IHIAGLHRAL KGVSHYLALK
210 220 230 240 250
TLLSLWTGVI VWLGLELMGV QFALMWAVLA FLLNYVPNIG AVISAVPPMI
260 270 280 290 300
QVLLFNGVYE CILVGALFLV VHMVIGNILE PRMMGHRLGM STMVVFLSLL
310 320 330 340
IWGWLLGPVG MLLSVPLTSV CKIWMETTKG GSKLAILLGP GRPKSRLPG
Length:349
Mass (Da):38,522
Last modified:December 20, 2005 - v1
Checksum:i275ADBAD4FD58257
GO

Sequence cautioni

The sequence AAB18449.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18449.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76499.2.
AP009048 Genomic DNA. Translation: BAE77819.1.
PIRiS47693.
RefSeqiNP_417931.4. NC_000913.3.
WP_001300885.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76499; AAC76499; b3474.
BAE77819; BAE77819; BAE77819.
GeneIDi947980.
KEGGiecj:JW5680.
eco:b3474.
PATRICi32122392. VBIEscCol129921_3573.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18449.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76499.2.
AP009048 Genomic DNA. Translation: BAE77819.1.
PIRiS47693.
RefSeqiNP_417931.4. NC_000913.3.
WP_001300885.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AGM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262490. 7 interactions.
STRINGi511145.b3474.

Protein family/group databases

TCDBi2.A.86.1.2. the autoinducer-2 exporter (ai-2e) family (formerly the perm family, tc #9.b.22).

Proteomic databases

PaxDbiP0AGM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76499; AAC76499; b3474.
BAE77819; BAE77819; BAE77819.
GeneIDi947980.
KEGGiecj:JW5680.
eco:b3474.
PATRICi32122392. VBIEscCol129921_3573.

Organism-specific databases

EchoBASEiEB2134.
EcoGeneiEG12220. yhhT.

Phylogenomic databases

eggNOGiENOG4105DSF. Bacteria.
COG0628. LUCA.
HOGENOMiHOG000290196.
InParanoidiP0AGM0.
OMAiIDNIPRY.
OrthoDBiEOG6VTK3P.
PhylomeDBiP0AGM0.

Enzyme and pathway databases

BioCyciEcoCyc:EG12220-MONOMER.
ECOL316407:JW5680-MONOMER.

Miscellaneous databases

PROiP0AGM0.

Family and domain databases

InterProiIPR002549. AI-2E-like.
[Graphical view]
PANTHERiPTHR21716. PTHR21716. 1 hit.
PfamiPF01594. UPF0118. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes."
    Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.
    Nucleic Acids Res. 22:2576-2586(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYHHT_ECOLI
AccessioniPrimary (citable) accession number: P0AGM0
Secondary accession number(s): P37622
, P76700, Q2M7D7, Q8X6P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 20, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.