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Protein

Ribose import permease protein RbsC

Gene

rbsC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex RbsABC involved in ribose import. Probably responsible for the translocation of the substrate across the membrane.2 Publications

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:RBSC-MONOMER.
ECOL316407:JW3729-MONOMER.
MetaCyc:RBSC-MONOMER.
RETL1328306-WGS:GSTH-2095-MONOMER.
RETL1328306-WGS:GSTH-2413-MONOMER.
RETL1328306-WGS:GSTH-4949-MONOMER.
RETL1328306-WGS:GSTH-5083-MONOMER.
RETL1328306-WGS:GSTH-5112-MONOMER.
RETL1328306-WGS:GSTH-624-MONOMER.
RETL1328306-WGS:GSTH-6917-MONOMER.

Protein family/group databases

TCDBi3.A.1.2.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose import permease protein RbsCCurated
Gene namesi
Name:rbsC1 Publication
Ordered Locus Names:b3750, JW3729
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10816. rbsC.

Subcellular locationi

  • Cell inner membrane 2 Publications; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222Cytoplasmic1 PublicationAdd
BLAST
Transmembranei23 – 4321Helical1 PublicationAdd
BLAST
Topological domaini44 – 5613Periplasmic1 PublicationAdd
BLAST
Transmembranei57 – 7721Helical1 PublicationAdd
BLAST
Topological domaini78 – 12548Cytoplasmic1 PublicationAdd
BLAST
Transmembranei126 – 14520Helical1 PublicationAdd
BLAST
Topological domaini146 – 16823Periplasmic1 PublicationAdd
BLAST
Transmembranei169 – 19022Helical1 PublicationAdd
BLAST
Topological domaini191 – 22030Cytoplasmic1 PublicationAdd
BLAST
Transmembranei221 – 24020Helical1 PublicationAdd
BLAST
Topological domaini241 – 29454Periplasmic1 PublicationAdd
BLAST
Transmembranei295 – 31622Helical1 PublicationAdd
BLAST
Topological domaini317 – 3215Cytoplasmic2 Publications

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Ribose import permease protein RbsCPRO_0000060223Add
BLAST

Proteomic databases

EPDiP0AGI1.
PaxDbiP0AGI1.
PRIDEiP0AGI1.

Interactioni

Subunit structurei

The complex is composed of an ATP-binding protein (RbsA), two transmembrane proteins (RbsC) and a solute-binding protein (RbsB).1 Publication

Protein-protein interaction databases

BioGridi4263450. 20 interactions.
STRINGi511145.b3750.

Structurei

3D structure databases

ProteinModelPortaliP0AGI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNN. Bacteria.
COG1172. LUCA.
HOGENOMiHOG000212232.
InParanoidiP0AGI1.
KOiK10440.
OMAiLAVMIDN.
OrthoDBiEOG61P6T8.
PhylomeDBiP0AGI1.

Family and domain databases

InterProiIPR001851. ABC_transp_permease.
[Graphical view]
PfamiPF02653. BPD_transp_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AGI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQTVSGRR YFTKAWLMEQ KSLIALLVLI AIVSTLSPNF FTINNLFNIL
60 70 80 90 100
QQTSVNAIMA VGMTLVILTS GIDLSVGSLL ALTGAVAASI VGIEVNALVA
110 120 130 140 150
VAAALALGAA IGAVTGVIVA KGRVQAFIAT LVMMLLLRGV TMVYTNGSPV
160 170 180 190 200
NTGFTENADL FGWFGIGRPL GVPTPVWIMG IVFLAAWYML HHTRLGRYIY
210 220 230 240 250
ALGGNEAATR LSGINVNKIK IIVYSLCGLL ASLAGIIEVA RLSSAQPTAG
260 270 280 290 300
TGYELDAIAA VVLGGTSLAG GKGRIVGTLI GALILGFLNN GLNLLGVSSY
310 320
YQMIVKAVVI LLAVLVDNKK Q
Length:321
Mass (Da):33,452
Last modified:December 20, 2005 - v1
Checksum:iC7292EE5F0C78781
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261A → P (PubMed:3011793).Curated
Sequence conflicti202 – 2021L → V in AAA51474 (PubMed:3011793).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13169 Genomic DNA. Translation: AAA51474.1.
L10328 Genomic DNA. Translation: AAA62103.1.
U00096 Genomic DNA. Translation: AAC76773.1.
AP009048 Genomic DNA. Translation: BAE77538.1.
PIRiG65178.
RefSeqiNP_418206.1. NC_000913.3.
WP_000211858.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76773; AAC76773; b3750.
BAE77538; BAE77538; BAE77538.
GeneIDi948262.
KEGGiecj:JW3729.
eco:b3750.
PATRICi32122999. VBIEscCol129921_3875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13169 Genomic DNA. Translation: AAA51474.1.
L10328 Genomic DNA. Translation: AAA62103.1.
U00096 Genomic DNA. Translation: AAC76773.1.
AP009048 Genomic DNA. Translation: BAE77538.1.
PIRiG65178.
RefSeqiNP_418206.1. NC_000913.3.
WP_000211858.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AGI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263450. 20 interactions.
STRINGi511145.b3750.

Protein family/group databases

TCDBi3.A.1.2.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

EPDiP0AGI1.
PaxDbiP0AGI1.
PRIDEiP0AGI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76773; AAC76773; b3750.
BAE77538; BAE77538; BAE77538.
GeneIDi948262.
KEGGiecj:JW3729.
eco:b3750.
PATRICi32122999. VBIEscCol129921_3875.

Organism-specific databases

EchoBASEiEB0809.
EcoGeneiEG10816. rbsC.

Phylogenomic databases

eggNOGiENOG4105CNN. Bacteria.
COG1172. LUCA.
HOGENOMiHOG000212232.
InParanoidiP0AGI1.
KOiK10440.
OMAiLAVMIDN.
OrthoDBiEOG61P6T8.
PhylomeDBiP0AGI1.

Enzyme and pathway databases

BioCyciEcoCyc:RBSC-MONOMER.
ECOL316407:JW3729-MONOMER.
MetaCyc:RBSC-MONOMER.
RETL1328306-WGS:GSTH-2095-MONOMER.
RETL1328306-WGS:GSTH-2413-MONOMER.
RETL1328306-WGS:GSTH-4949-MONOMER.
RETL1328306-WGS:GSTH-5083-MONOMER.
RETL1328306-WGS:GSTH-5112-MONOMER.
RETL1328306-WGS:GSTH-624-MONOMER.
RETL1328306-WGS:GSTH-6917-MONOMER.

Miscellaneous databases

PROiP0AGI1.

Family and domain databases

InterProiIPR001851. ABC_transp_permease.
[Graphical view]
PfamiPF02653. BPD_transp_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequences of the rbsD, rbsA, and rbsC genes of Escherichia coli K12."
    Bell A.W., Buckel S.D., Groarke J.M., Hope J.N., Kingsley D.H., Hermodson M.A.
    J. Biol. Chem. 261:7652-7658(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication."
    Burland V.D., Plunkett G. III, Daniels D.L., Blattner F.R.
    Genomics 16:551-561(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Molecular cloning and characterization of genes required for ribose transport and utilization in Escherichia coli K-12."
    Iida A., Harayama S., Iino T., Hazelbauer G.L.
    J. Bacteriol. 158:674-682(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Topology of RbsC, a membrane component of the ribose transporter, belonging to the AraH superfamily."
    Park Y., Park C.
    J. Bacteriol. 181:1039-1042(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY, SUBCELLULAR LOCATION.
  7. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.
    Strain: K12 / MG1655 / ATCC 47076.
  8. "In vitro reassembly of the ribose ATP-binding cassette transporter reveals a distinct set of transport complexes."
    Clifton M.C., Simon M.J., Erramilli S.K., Zhang H., Zaitseva J., Hermodson M.A., Stauffacher C.V.
    J. Biol. Chem. 290:5555-5565(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.

Entry informationi

Entry nameiRBSC_ECOLI
AccessioniPrimary (citable) accession number: P0AGI1
Secondary accession number(s): P04984, Q2M868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: December 20, 2005
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.