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Protein

Putrescine export system permease protein SapC

Gene

sapC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides.1 Publication

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:SAPC-MONOMER.

Protein family/group databases

TCDBi3.A.1.5.42. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Putrescine export system permease protein SapCCurated
Gene namesi
Name:sapC
Ordered Locus Names:b1292, JW1285
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG20256. sapC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 49HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini50 – 98PeriplasmicSequence analysisAdd BLAST49
Transmembranei99 – 119HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini120 – 133CytoplasmicSequence analysisAdd BLAST14
Transmembranei134 – 154HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini155 – 196PeriplasmicSequence analysisAdd BLAST42
Transmembranei197 – 217HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini218 – 222CytoplasmicSequence analysis5
Transmembranei223 – 243HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini244 – 257PeriplasmicSequence analysisAdd BLAST14
Transmembranei258 – 278HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini279 – 296CytoplasmicSequence analysis1 PublicationAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Single mutation, decreased extracellular putrescine, in an sapBCDF operon deletion no change in resistance to antimicrobial peptide LL-37.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000601631 – 296Putrescine export system permease protein SapCAdd BLAST296

Proteomic databases

PaxDbiP0AGH5.
PRIDEiP0AGH5.

Interactioni

Protein-protein interaction databases

BioGridi4263003. 184 interactors.
DIPiDIP-10824N.
IntActiP0AGH5. 1 interactor.
MINTiMINT-1289680.
STRINGi511145.b1292.

Structurei

3D structure databases

ProteinModelPortaliP0AGH5.
SMRiP0AGH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 284ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST186

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108EU3. Bacteria.
COG4171. LUCA.
HOGENOMiHOG000171368.
InParanoidiP0AGH5.
KOiK19228.
OMAiFGSWFAP.
PhylomeDBiP0AGH5.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiView protein in InterPro
IPR000515. MetI-like.
IPR025966. OppC_N.
PfamiView protein in Pfam
PF00528. BPD_transp_1. 1 hit.
PF12911. OppC_N. 1 hit.
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiView protein in PROSITE
PS50928. ABC_TM1. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AGH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYDSVYSEK RPPGTLRTAW RKFYSDASAM VGLYGCAGLA VLCIFGGWFA
60 70 80 90 100
PYGIDQQFLG YQLLPPSWSR YGEVSFFLGT DDLGRDVLSR LLSGAAPTVG
110 120 130 140 150
GAFVVTLAAT ICGLVLGTFA GATHGLRSAV LNHILDTLLA IPSLLLAIIV
160 170 180 190 200
VAFAGPSLSH AMFAVWLALL PRMVRSIYSM VHDELEKEYV IAARLDGAST
210 220 230 240 250
LNILWFAVMP NITAGLVTEI TRALSMAILD IAALGFLDLG AQLPSPEWGA
260 270 280 290
MLGDALELIY VAPWTVMLPG AAIMISVLLV NLLGDGVRRA IIAGVE
Length:296
Mass (Da):31,548
Last modified:December 20, 2005 - v1
Checksum:i57CD1F8180BF0B7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97282 Genomic DNA. Translation: CAA65939.1.
U00096 Genomic DNA. Translation: AAC74374.1.
AP009048 Genomic DNA. Translation: BAA14845.1.
PIRiG64877.
RefSeqiNP_415808.1. NC_000913.3.
WP_001146163.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74374; AAC74374; b1292.
BAA14845; BAA14845; BAA14845.
GeneIDi945266.
KEGGiecj:JW1285.
eco:b1292.
PATRICi32117854. VBIEscCol129921_1347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97282 Genomic DNA. Translation: CAA65939.1.
U00096 Genomic DNA. Translation: AAC74374.1.
AP009048 Genomic DNA. Translation: BAA14845.1.
PIRiG64877.
RefSeqiNP_415808.1. NC_000913.3.
WP_001146163.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AGH5.
SMRiP0AGH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263003. 184 interactors.
DIPiDIP-10824N.
IntActiP0AGH5. 1 interactor.
MINTiMINT-1289680.
STRINGi511145.b1292.

Protein family/group databases

TCDBi3.A.1.5.42. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AGH5.
PRIDEiP0AGH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74374; AAC74374; b1292.
BAA14845; BAA14845; BAA14845.
GeneIDi945266.
KEGGiecj:JW1285.
eco:b1292.
PATRICi32117854. VBIEscCol129921_1347.

Organism-specific databases

EchoBASEiEB4157.
EcoGeneiEG20256. sapC.

Phylogenomic databases

eggNOGiENOG4108EU3. Bacteria.
COG4171. LUCA.
HOGENOMiHOG000171368.
InParanoidiP0AGH5.
KOiK19228.
OMAiFGSWFAP.
PhylomeDBiP0AGH5.

Enzyme and pathway databases

BioCyciEcoCyc:SAPC-MONOMER.

Miscellaneous databases

PROiPR:P0AGH5.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiView protein in InterPro
IPR000515. MetI-like.
IPR025966. OppC_N.
PfamiView protein in Pfam
PF00528. BPD_transp_1. 1 hit.
PF12911. OppC_N. 1 hit.
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiView protein in PROSITE
PS50928. ABC_TM1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSAPC_ECOLI
AccessioniPrimary (citable) accession number: P0AGH5
Secondary accession number(s): Q47624
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 15, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.