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Protein

Metalloprotease TldD

Gene

tldD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).1 Publication

Miscellaneous

In strains containing the pMccB17 plasmid, required for the maturation and secretion of the antibiotic bacteriocin microcin B17 (MccB17).1 Publication

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: EcoCyc

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease

Enzyme and pathway databases

BioCyciEcoCyc:G7689-MONOMER.

Protein family/group databases

MEROPSiU62.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloprotease TldD (EC:3.4.-.-)
Gene namesi
Name:tldD
Synonyms:yhdO
Ordered Locus Names:b3244, JW3213
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12826. tldD.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001423571 – 481Metalloprotease TldDAdd BLAST481

Proteomic databases

EPDiP0AGG8.
PaxDbiP0AGG8.
PRIDEiP0AGG8.

Interactioni

Protein-protein interaction databases

BioGridi4260797. 17 interactors.
DIPiDIP-47845N.
IntActiP0AGG8. 4 interactors.
STRINGi316385.ECDH10B_3421.

Structurei

Secondary structure

1481
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 10Combined sources8
Helixi12 – 14Combined sources3
Helixi18 – 29Combined sources12
Beta strandi34 – 51Combined sources18
Beta strandi54 – 72Combined sources19
Beta strandi75 – 83Combined sources9
Helixi86 – 96Combined sources11
Helixi97 – 99Combined sources3
Turni125 – 127Combined sources3
Helixi131 – 148Combined sources18
Beta strandi152 – 170Combined sources19
Beta strandi173 – 193Combined sources21
Beta strandi196 – 208Combined sources13
Helixi210 – 214Combined sources5
Beta strandi215 – 217Combined sources3
Helixi222 – 239Combined sources18
Beta strandi245 – 252Combined sources8
Helixi256 – 258Combined sources3
Helixi259 – 264Combined sources6
Helixi267 – 269Combined sources3
Helixi271 – 275Combined sources5
Turni280 – 283Combined sources4
Beta strandi296 – 299Combined sources4
Beta strandi320 – 325Combined sources6
Helixi336 – 342Combined sources7
Beta strandi364 – 368Combined sources5
Helixi375 – 380Combined sources6
Beta strandi383 – 397Combined sources15
Turni398 – 401Combined sources4
Beta strandi402 – 414Combined sources13
Beta strandi417 – 422Combined sources6
Beta strandi426 – 430Combined sources5
Helixi431 – 436Combined sources6
Beta strandi438 – 443Combined sources6
Beta strandi452 – 456Combined sources5
Beta strandi459 – 467Combined sources9
Beta strandi470 – 478Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NJ5X-ray1.90A/C1-481[»]
5NJ9X-ray1.25A/C1-481[»]
5NJAX-ray1.40A/C1-481[»]
5NJBX-ray1.50A/C1-481[»]
5NJCX-ray1.35A/C1-481[»]
5NJFX-ray1.42A/C1-481[»]
ProteinModelPortaliP0AGG8.
SMRiP0AGG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase U62 family.Curated

Phylogenomic databases

eggNOGiENOG4105D1U. Bacteria.
COG0312. LUCA.
HOGENOMiHOG000224929.
InParanoidiP0AGG8.
KOiK03568.
OMAiTTDFWGS.
PhylomeDBiP0AGG8.

Family and domain databases

Gene3Di3.30.2290.10. 1 hit.
InterProiView protein in InterPro
IPR025502. TldD.
IPR002510. TldD/PmbA.
IPR035068. TldD/PmbA_N.
IPR036059. TldD/PmbA_sf.
PfamiView protein in Pfam
PF01523. PmbA_TldD. 1 hit.
PIRSFiPIRSF004919. TldD. 1 hit.
SUPFAMiSSF111283. SSF111283. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AGG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNLVSEQL LAANGLKHQD LFAILGQLAE RRLDYGDLYF QSSYHESWVL
60 70 80 90 100
EDRIIKDGSY NIDQGVGVRA ISGEKTGFAY ADQISLLALE QSAQAARTIV
110 120 130 140 150
RDSGDGKVQT LGAVEHSPLY TSVDPLQSMS REEKLDILRR VDKVAREADK
160 170 180 190 200
RVQEVTASLS GVYELILVAA TDGTLAADVR PLVRLSVSVL VEEDGKRERG
210 220 230 240 250
ASGGGGRFGY EFFLADLDGE VRADAWAKEA VRMALVNLSA VAAPAGTMPV
260 270 280 290 300
VLGAGWPGVL LHEAVGHGLE GDFNRRGTSV FSGQVGELVA SELCTVVDDG
310 320 330 340 350
TMVDRRGSVA IDDEGTPGQY NVLIENGILK GYMQDKLNAR LMGMTPTGNG
360 370 380 390 400
RRESYAHLPM PRMTNTYMLP GKSTPQEIIE SVEYGIYAPN FGGGQVDITS
410 420 430 440 450
GKFVFSTSEA YLIENGKVTK PVKGATLIGS GIETMQQISM VGNDLKLDNG
460 470 480
VGVCGKEGQS LPVGVGQPTL KVDNLTVGGT A
Length:481
Mass (Da):51,364
Last modified:December 20, 2005 - v1
Checksum:iC2D9F681B305FECD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44451 Genomic DNA. Translation: BAA07913.1.
U18997 Genomic DNA. Translation: AAA58046.1.
U00096 Genomic DNA. Translation: AAC76276.1.
AP009048 Genomic DNA. Translation: BAE77287.1.
PIRiF65116.
RefSeqiNP_417711.1. NC_000913.3.
WP_000055909.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76276; AAC76276; b3244.
BAE77287; BAE77287; BAE77287.
GeneIDi947749.
KEGGiecj:JW3213.
eco:b3244.
PATRICifig|1411691.4.peg.3484.

Similar proteinsi

Entry informationi

Entry nameiTLDD_ECOLI
AccessioniPrimary (citable) accession number: P0AGG8
Secondary accession number(s): P46473, Q2M8W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome