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P0AGG7 (THIO2_SHIFL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thioredoxin-2
Short name=Trx-2
EC=1.8.1.8
Alternative name(s):
Protein-disulfide reductase
Gene names
Name:trxC
Ordered Locus Names:SF2644, S2817
OrganismShigella flexneri [Complete proteome] [HAMAP]
Taxonomic identifier623 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length139 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin By similarity.

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the thioredoxin family.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 139139Thioredoxin-2
PRO_0000120105

Regions

Domain26 – 139114Thioredoxin
Zinc finger5 – 1814 Potential

Amino acid modifications

Disulfide bond64 ↔ 67Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P0AGG7 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 4C973F6FE55C8856

FASTA13915,555
        10         20         30         40         50         60 
MNTVCTHCQA INRIPDDRIE DAAKCGRCGH DLFDGEVINA TGETLDKLLK DDLPVVIDFW 

        70         80         90        100        110        120 
APWCGPCRNF APIFEDVAQE RSGKVRFVKV NTEAERELSS RFGIRSIPTI MIFKNGQVVD 

       130 
MLNGAVPKAP FDSWLNESL

« Hide

References

[1]"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. expand/collapse author list , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 301 / Serotype 2a.
[2]"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T."
Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.
Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700930 / 2457T / Serotype 2a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005674 Genomic DNA. Translation: AAN44140.1.
AE014073 Genomic DNA. Translation: AAP17964.1.
RefSeqNP_708433.1. NC_004337.2.
NP_838154.1. NC_004741.1.

3D structure databases

ProteinModelPortalP0AGG7.
SMRP0AGG7. Positions 36-139.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000087881; EBESCP00000084703; EBESCG00000086926.
EBESCT00000092841; EBESCP00000089477; EBESCG00000091885.
GeneID1026952.
1079081.
GenomeReviewsGene locus SF2644 in contig AE005674_GR.
Gene locus S2817 in contig AE014073_GR.
KEGGsfl:SF2644.
sfx:S2817.
PATRIC18707283. VBIShiFle31049_3109.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000008978.
HOGENOMHBG493509.
OMAMIFKQGH.
ProtClustDBPRK10996.

Enzyme and pathway databases

BioCycSFLE198214:AAN44140.1-MONOMER.

Family and domain databases

InterProIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KOK03672.
PANTHERPTHR10438. Trx. 1 hit.
PfamPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFPIRSF000077. Thioredoxin. 1 hit.
PRINTSPR00421. THIOREDOXIN.
SUPFAMSSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMsTIGR01068. Thioredoxin. 1 hit.
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHIO2_SHIFL
AccessionPrimary (citable) accession number: P0AGG7
Secondary accession number(s): P33636 expand/collapse secondary AC list , P76593, P77000, P77001
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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