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Reviewed, UniProtKB/Swiss-Prot P0AGG6 (THIO2_ECO57)

Last modified June 16, 2009. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Thioredoxin-2
      Short name=Trx-2
    EC=1.8.1.8
Alternative name(s):
    Protein-disulfide reductase
Gene names
Name: trxC
Ordered Locus Names: Z3867, ECs3448
OrganismEscherichia coli O157:H7 [Complete proteome] [HAMAP]
Taxonomic identifier83334 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length139 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin By similarity.

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the thioredoxin family.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 139139Thioredoxin-2
PRO_0000120103

Regions

Domain26 – 139114Thioredoxin
Zinc finger5 – 1814 Potential

Amino acid modifications

Disulfide bond64 ↔ 67Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P0AGG6-1 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 4C973F6FE55C8856

FASTA13915,555
        10         20         30         40         50         60 
MNTVCTHCQA INRIPDDRIE DAAKCGRCGH DLFDGEVINA TGETLDKLLK DDLPVVIDFW 

        70         80         90        100        110        120 
APWCGPCRNF APIFEDVAQE RSGKVRFVKV NTEAERELSS RFGIRSIPTI MIFKNGQVVD 

       130 
MLNGAVPKAP FDSWLNESL 

« Hide

References

Cross-references

Sequence databases

AE005174 Genomic DNA. Translation: AAG57699.1.
BA000007 Genomic DNA. Translation: BAB36871.1.
PIRG85904.
H91059.
RefSeqNP_289141.1.
NP_311475.1.

3D structure databases

HSSPHSSP built from PDB template 1DBY based on UniProtKB P23400.
ModBaseSearch...

Genome annotation databases

GeneID914878.
957981.
GenomeReviewsGene locus Z3867 in contig AE005174_GR.
Gene locus ECs3448 in contig BA000007_GR.
KEGGece:Z3867.
ecs:ECs3448.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP0AGG6.
OMAP0AGG6. MIFKQGH.

Enzyme and pathway databases

BioCycECOL83334:ECS3448-MON.

Family and domain databases

InterProIPR005746. Thioredoxin.
IPR017936. Thioredoxin-like.
IPR006662. Thioredoxin-like_subdom.
IPR015467. Thioredoxin_core.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR10438. Trx. 1 hit.
PfamPF00085. Thioredoxin. 1 hit.
[Graphical view]
PRINTSPR00421. THIOREDOXIN.
TIGRFAMsTIGR01068. thioredoxin. 1 hit.
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHIO2_ECO57
AccessionPrimary (citable) accession number: P0AGG6
Secondary accession number(s): P33636 expand/collapse secondary AC list , P76593, P77000, P77001
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents