P0AGE3 (SSB_SHIFL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Single-stranded DNA-binding protein
Short name=SSB

Alternative name(s):
Helix-destabilizing protein

Gene names

Name:	ssb
Ordered Locus Names:	SF4145, S3584

Organism

Shigella flexneri [Complete proteome] [HAMAP]

Taxonomic identifier

623 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is essential for replication of the chromosome. It is also involved in DNA recombination and repair By similarity.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Contains 1 SSB domain.

Ontologies

Keywords
Biological process	DNA damage DNA repair DNA replication
Ligand	DNA-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	single-stranded DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 178	177	Single-stranded DNA-binding protein		PRO_0000096039
Regions
	Domain	6 – 111	106	SSB
	DNA binding	55 – 61	7	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0AGE3 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: F0AF43B6DC8D02FC	FASTA	178	18,975
	10 20 30 40 50 60 MASRGVNKVI LVGNLGQDPE VRYMPNGGAV ANITLATSES WRDKATGEMK EQTEWHRVVL 70 80 90 100 110 120 FGKLAEVASE YLRKGSQVYI EGQLRTRKWT DQSGQDRYTT EVVVNVGGTM QMLGGRQGGG 130 140 150 160 170 APAGGNIGGG QPQGGWGQPQ QPQGGNQFSG GAQSRPQQSA PAAPSNEPPM DFDDDIPF

References

[1]

"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J. Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a.

[2]

"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005674 Genomic DNA. Translation: AAN45567.2. AE014073 Genomic DNA. Translation: AAP18630.1.
RefSeq	NP_709860.2. NC_004337.2. NP_838819.1. NC_004741.1.
3D structure databases
ProteinModelPortal	P0AGE3.
SMR	P0AGE3. Positions 2-123.
ModBase	Search...
Protein-protein interaction databases
STRING	198214.SF4145.
Proteomic databases
PaxDb	P0AGE3.
PRIDE	P0AGE3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN45567; AAN45567; SF4145. AAP18630; AAP18630; S3584.
GeneID	1024145. 1079806.
KEGG	sfl:SF4145. sfx:S3584.
PATRIC	18708948. VBIShiFle31049_3912.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0629.
HOGENOM	HOG000106483.
KO	K03111.
ProtClustDB	PRK09010.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
InterPro	IPR012340. NA-bd_OB-fold. IPR000424. Primosome_PriB/ssb. IPR011344. ssDNA-bd. [Graphical view]
PANTHER	PTHR10302. PTHR10302. 1 hit.
Pfam	PF00436. SSB. 1 hit. [Graphical view]
PIRSF	PIRSF002070. SSB. 1 hit.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00621. ssb. 1 hit.
PROSITE	PS50935. SSB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SSB_SHIFL

Accession

Primary (citable) accession number: P0AGE3
Secondary accession number(s): P02339

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program