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Protein

Superoxide dismutase [Fe]

Gene

sodB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.1 Publication

Cofactori

Fe cation1 PublicationNote: Binds 1 Fe cation per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Iron1
Metal bindingi74Iron1
Metal bindingi157Iron1
Metal bindingi161Iron1

GO - Molecular functioni

  • iron ion binding Source: EcoCyc
  • oxidoreductase activity Source: EcoliWiki
  • superoxide dismutase activity Source: EcoliWiki

GO - Biological processi

  • oxidation-reduction process Source: EcoliWiki
  • removal of superoxide radicals Source: EcoliWiki
  • response to superoxide Source: EcoliWiki
  • superoxide metabolic process Source: EcoliWiki

Keywordsi

Molecular functionOxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:SUPEROX-DISMUTFE-MONOMER
MetaCyc:SUPEROX-DISMUTFE-MONOMER
BRENDAi1.15.1.1 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] (EC:1.15.1.1)
Gene namesi
Name:sodB
Ordered Locus Names:b1656, JW1648
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10954 sodB

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: UniProtKB
  • membrane Source: UniProtKB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00001599792 – 193Superoxide dismutase [Fe]Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51N6-acetyllysine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP0AGD3
PaxDbiP0AGD3
PRIDEiP0AGD3

2D gel databases

SWISS-2DPAGEiP0AGD3

PTM databases

iPTMnetiP0AGD3

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi426026563 interactors.
IntActiP0AGD3 6 interactors.
STRINGi316385.ECDH10B_1790

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni12 – 18Combined sources7
Helixi21 – 29Combined sources9
Helixi31 – 43Combined sources13
Turni47 – 50Combined sources4
Helixi53 – 57Combined sources5
Helixi62 – 79Combined sources18
Helixi91 – 101Combined sources11
Helixi104 – 117Combined sources14
Beta strandi120 – 128Combined sources9
Beta strandi134 – 140Combined sources7
Helixi145 – 147Combined sources3
Beta strandi151 – 157Combined sources7
Helixi160 – 162Combined sources3
Helixi164 – 167Combined sources4
Helixi171 – 179Combined sources9
Helixi184 – 192Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ISAX-ray1.80A/B2-193[»]
1ISBX-ray1.85A/B2-193[»]
1ISCX-ray1.80A/B2-193[»]
1ZA5X-ray1.80A/B2-193[»]
2BKBX-ray1.70A/B/C/D2-193[»]
2NYBX-ray1.10A/B/C/D2-193[»]
ProteinModelPortaliP0AGD3
SMRiP0AGD3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AGD3

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4 Bacteria
COG0605 LUCA
HOGENOMiHOG000013584
InParanoidiP0AGD3
KOiK04564
OMAiKWGSFDK
PhylomeDBiP0AGD3

Family and domain databases

Gene3Di1.10.287.9901 hit
2.40.500.201 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AGD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFELPALPY AKDALAPHIS AETIEYHYGK HHQTYVTNLN NLIKGTAFEG
60 70 80 90 100
KSLEEIIRSS EGGVFNNAAQ VWNHTFYWNC LAPNAGGEPT GKVAEAIAAS
110 120 130 140 150
FGSFADFKAQ FTDAAIKNFG SGWTWLVKNS DGKLAIVSTS NAGTPLTTDA
160 170 180 190
TPLLTVDVWE HAYYIDYRNA RPGYLEHFWA LVNWEFVAKN LAA
Length:193
Mass (Da):21,266
Last modified:January 23, 2007 - v2
Checksum:i91236D2A8FE61474
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03511 Genomic DNA Translation: AAA24637.1
U00096 Genomic DNA Translation: AAC74728.1
AP009048 Genomic DNA Translation: BAA15422.1
PIRiA29940 DSECF
RefSeqiNP_416173.1, NC_000913.3
WP_000007283.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74728; AAC74728; b1656
BAA15422; BAA15422; BAA15422
GeneIDi944953
KEGGiecj:JW1648
eco:b1656
PATRICifig|1411691.4.peg.602

Similar proteinsi

Entry informationi

Entry nameiSODF_ECOLI
AccessioniPrimary (citable) accession number: P0AGD3
Secondary accession number(s): P09157
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome