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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationNote: Binds 1 copper ion per subunit.
  • Zn2+Note: Binds 1 zinc ion per subunit.

Temperature dependencei

Highly thermostable.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Copper; catalytic1
Metal bindingi69Copper; catalytic1
Metal bindingi92Copper; catalytic1
Metal bindingi92Zinc; structural1
Metal bindingi101Zinc; structural1
Metal bindingi109Zinc; structural1
Metal bindingi112Zinc; structural1
Metal bindingi147Copper; catalytic1

GO - Molecular functioni

  • copper ion binding Source: EcoliWiki
  • superoxide dismutase activity Source: EcoliWiki
  • zinc ion binding Source: EcoliWiki

GO - Biological processi

  • superoxide metabolic process Source: EcoliWiki

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G6886-MONOMER
MetaCyc:G6886-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Alternative name(s):
Bacteriocuprein
Gene namesi
Name:sodC
Ordered Locus Names:b1646, JW1638
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13419 sodC

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • outer membrane-bounded periplasmic space Source: EcoCyc
  • periplasmic space Source: EcoliWiki

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003282420 – 173Superoxide dismutase [Cu-Zn]Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi74 ↔ 1691 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP0AGD1
PaxDbiP0AGD1
PRIDEiP0AGD1

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi4259604, 26 interactors
STRINGi316385.ECDH10B_1780

Structurei

Secondary structure

1173
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 30Combined sources10
Beta strandi33 – 46Combined sources14
Beta strandi49 – 56Combined sources8
Beta strandi61 – 64Combined sources4
Beta strandi66 – 72Combined sources7
Beta strandi80 – 82Combined sources3
Helixi87 – 89Combined sources3
Beta strandi106 – 108Combined sources3
Beta strandi116 – 118Combined sources3
Beta strandi128 – 130Combined sources3
Helixi136 – 139Combined sources4
Beta strandi142 – 149Combined sources8
Beta strandi153 – 158Combined sources6
Helixi159 – 162Combined sources4
Beta strandi165 – 172Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ESOX-ray2.00A20-173[»]
ProteinModelPortaliP0AGD1
SMRiP0AGD1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AGD1

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108Z7T Bacteria
COG2032 LUCA
HOGENOMiHOG000263449
InParanoidiP0AGD1
KOiK04565
OMAiHKGDIGN
PhylomeDBiP0AGD1

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AGD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRFSLAILA LVVATGAQAA SEKVEMNLVT SQGVGQSIGS VTITETDKGL
60 70 80 90 100
EFSPDLKALP PGEHGFHIHA KGSCQPATKD GKASAAESAG GHLDPQNTGK
110 120 130 140 150
HEGPEGAGHL GDLPALVVNN DGKATDAVIA PRLKSLDEIK DKALMVHVGG
160 170
DNMSDQPKPL GGGGERYACG VIK
Length:173
Mass (Da):17,681
Last modified:December 20, 2005 - v1
Checksum:i9A0CB65F03AAB197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51242 Genomic DNA Translation: AAB03729.1
U00096 Genomic DNA Translation: AAC74718.1
AP009048 Genomic DNA Translation: BAE76489.1
X97766 Genomic DNA Translation: CAA66363.1
PIRiJC6004
RefSeqiNP_416163.1, NC_000913.3
WP_001296937.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74718; AAC74718; b1646
BAE76489; BAE76489; BAE76489
GeneIDi945343
KEGGiecj:JW1638
eco:b1646
PATRICifig|1411691.4.peg.613

Similar proteinsi

Entry informationi

Entry nameiSODC_ECOLI
AccessioniPrimary (citable) accession number: P0AGD1
Secondary accession number(s): P53635, P96756, Q2MB67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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