ID   SERB_ECOLI              Reviewed;         322 AA.
AC   P0AGB0; P06862; Q2M5S9;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Phosphoserine phosphatase;
DE            Short=PSPase;
DE            Short=PSP;
DE            EC=3.1.3.3;
DE   AltName: Full=O-phosphoserine phosphohydrolase;
GN   Name=serB; OrderedLocusNames=b4388, JW4351;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12;
RX   MEDLINE=86041894; PubMed=2997734; DOI=10.1093/nar/13.19.7025;
RA   Neuwald A.F., Stauffer G.V.;
RT   "DNA sequence and characterization of the Escherichia coli serB
RT   gene.";
RL   Nucleic Acids Res. 13:7025-7039(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   MEDLINE=95334362; PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L.,
RA   Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the
RT   region from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA   Mau B., Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1474(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains
RT   MG1655 and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- CATALYTIC ACTIVITY: O-phospho-L(or D)-serine + H(2)O = L(or D)-
CC       serine + phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine
CC       from 3-phospho-D-glyceric acid: step 3/3.
CC   -!- INTERACTION:
CC       P18843:nadE; NbExp=1; IntAct=EBI-1126007, EBI-548960;
CC   -!- SIMILARITY: Belongs to the serB family.
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DR   EMBL; X03046; CAA26852.1; -; Genomic_DNA.
DR   EMBL; U14003; AAA97284.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77341.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78377.1; -; Genomic_DNA.
DR   PIR; A24271; PAECS.
DR   RefSeq; AP_004876.1; -.
DR   RefSeq; NP_418805.1; -.
DR   HSSP; Q58989; 1J97.
DR   IntAct; P0AGB0; 3.
DR   GeneID; 948913; -.
DR   GenomeReviews; AP009048_GR; JW4351.
DR   GenomeReviews; U00096_GR; b4388.
DR   KEGG; ecj:JW4351; -.
DR   KEGG; eco:b4388; -.
DR   EchoBASE; EB0938; -.
DR   EcoGene; EG10945; serB.
DR   HOGENOM; P0AGB0; -.
DR   OMA; P0AGB0; GFTYFSD.
DR   BioCyc; EcoCyc:PSERPHOSPHA-MON; -.
DR   GO; GO:0004647; F:phosphoserine phosphatase activity; IEA:EC.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005834; Dehalogen-like_hydro.
DR   InterPro; IPR006383; HAD-SF_hydro_IB_PSP-like.
DR   InterPro; IPR004469; SerB.
DR   Pfam; PF00702; Hydrolase; 1.
DR   TIGRFAMs; TIGR01488; HAD-SF-IB; 1.
DR   TIGRFAMs; TIGR00338; serB; 1.
PE   1: Evidence at protein level;
KW   Amino-acid biosynthesis; Complete proteome; Hydrolase;
KW   Serine biosynthesis.
FT   CHAIN         1    322       Phosphoserine phosphatase.
FT                                /FTId=PRO_0000156886.
SQ   SEQUENCE   322 AA;  35043 MW;  A09A43BD846B7DE6 CRC64;
     MPNITWCDLP EDVSLWPGLP LSLSGDEVMP LDYHAGRSGW LLYGRGLDKQ RLTQYQSKLG
     AAMVIVAAWC VEDYQVIRLA GSLTARATRL AHEAQLDVAP LGKIPHLRTP GLLVMDMDST
     AIQIECIDEI AKLAGTGEMV AEVTERAMRG ELDFTASLRS RVATLKGADA NILQQVRENL
     PLMPGLTQLV LKLETLGWKV AIASGGFTFF AEYLRDKLRL TAVVANELEI MDGKFTGNVI
     GDIVDAQYKA KTLTRLAQEY EIPLAQTVAI GDGANDLPMI KAAGLGIAYH AKPKVNEKAE
     VTIRHADLMG VFCILSGSLN QK
//