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Protein

Transcriptional regulatory protein UhpA

Gene

uhpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcription of the uhpT gene. Acts by binding specifically to the uhpT promoter region.2 Publications

Enzyme regulationi

Phosphorylation by UhpB enhances DNA binding activity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi155 – 174H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: EcoCyc

GO - Biological processi

  • phosphorelay signal transduction system Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyciEcoCyc:UHPA-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein UhpACurated
Gene namesi
Name:uhpA
Ordered Locus Names:b3669, JW3644
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11051 uhpA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54D → N: Lack of phosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000812571 – 196Transcriptional regulatory protein UhpAAdd BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphatePROSITE-ProRule annotation1 Publication1

Post-translational modificationi

Phosphorylated and dephosphorylated by UhpB.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0AGA6
PRIDEiP0AGA6

Interactioni

Protein-protein interaction databases

BioGridi4262584, 23 interactors
DIPiDIP-11082N
IntActiP0AGA6, 4 interactors
STRINGi316385.ECDH10B_3852

Structurei

3D structure databases

ProteinModelPortaliP0AGA6
SMRiP0AGA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 116Response regulatoryPROSITE-ProRule annotationAdd BLAST114
Domaini131 – 196HTH luxR-typePROSITE-ProRule annotationAdd BLAST66

Phylogenomic databases

eggNOGiENOG4108KX4 Bacteria
COG2197 LUCA
HOGENOMiHOG000034813
InParanoidiP0AGA6
KOiK07686
OMAiDHPMWRD
PhylomeDBiP0AGA6

Family and domain databases

CDDicd06170 LuxR_C_like, 1 hit
cd00156 REC, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR016032 Sig_transdc_resp-reg_C-effctor
IPR001789 Sig_transdc_resp-reg_receiver
IPR000792 Tscrpt_reg_LuxR_C
PfamiView protein in Pfam
PF00196 GerE, 1 hit
PF00072 Response_reg, 1 hit
PRINTSiPR00038 HTHLUXR
SMARTiView protein in SMART
SM00421 HTH_LUXR, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF46894 SSF46894, 1 hit
SSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS00622 HTH_LUXR_1, 1 hit
PS50043 HTH_LUXR_2, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

P0AGA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITVALIDDH LIVRSGFAQL LGLEPDLQVV AEFGSGREAL AGLPGRGVQV
60 70 80 90 100
CICDISMPDI SGLELLSQLP KGMATIMLSV HDSPALVEQA LNAGARGFLS
110 120 130 140 150
KRCSPDELIA AVHTVATGGC YLTPDIAIKL ASGRQDPLTK RERQVAEKLA
160 170 180 190
QGMAVKEIAA ELGLSPKTVH VHRANLMEKL GVSNDVELAR RMFDGW
Length:196
Mass (Da):20,889
Last modified:December 20, 2005 - v1
Checksum:i8F409F8AADE08276
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17102 Genomic DNA Translation: AAA24720.1
M89479 Genomic DNA Translation: AAA24724.1
L10328 Genomic DNA Translation: AAA62021.1
U00096 Genomic DNA Translation: AAC76692.1
AP009048 Genomic DNA Translation: BAE77624.1
PIRiA26925 BVECAU
RefSeqiNP_418125.1, NC_000913.3
WP_000633668.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76692; AAC76692; b3669
BAE77624; BAE77624; BAE77624
GeneIDi948178
KEGGiecj:JW3644
eco:b3669
PATRICifig|1411691.4.peg.3036

Similar proteinsi

Entry informationi

Entry nameiUHPA_ECOLI
AccessioniPrimary (citable) accession number: P0AGA6
Secondary accession number(s): P10940, Q2M7Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health