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Protein

Uncharacterized oxidoreductase YghA

Gene

yghA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei186 – 1861SubstrateBy similarity
Active sitei199 – 1991Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 7725NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

  • alcohol dehydrogenase (NADP+) activity Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciEcoCyc:EG11292-MONOMER.
ECOL316407:JW2972-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized oxidoreductase YghA (EC:1.-.-.-)
Gene namesi
Name:yghA
Ordered Locus Names:b3003, JW2972
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11292. yghA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Uncharacterized oxidoreductase YghAPRO_0000054837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP0AG84.
PaxDbiP0AG84.
PRIDEiP0AG84.

Interactioni

Protein-protein interaction databases

BioGridi4261414. 14 interactions.
DIPiDIP-36027N.
IntActiP0AG84. 6 interactions.
MINTiMINT-1264908.
STRINGi511145.b3003.

Structurei

3D structure databases

ProteinModelPortaliP0AG84.
SMRiP0AG84. Positions 3-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CYX. Bacteria.
ENOG410XNUN. LUCA.
InParanoidiP0AG84.
OMAiAYEGNEQ.
OrthoDBiEOG6N3CR8.
PhylomeDBiP0AG84.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AG84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLKDPTTQ YYTGEYPKQK QPTPGIQAKM TPVPDCGEKT YVGSGRLKDR
60 70 80 90 100
KALVTGGDSG IGRAAAIAYA REGADVAISY LPVEEEDAQD VKKIIEECGR
110 120 130 140 150
KAVLLPGDLS DEKFARSLVH EAHKALGGLD IMALVAGKQV AIPDIADLTS
160 170 180 190 200
EQFQKTFAIN VFALFWLTQE AIPLLPKGAS IITTSSIQAY QPSPHLLDYA
210 220 230 240 250
ATKAAILNYS RGLAKQVAEK GIRVNIVAPG PIWTALQISG GQTQDKIPQF
260 270 280 290
GQQTPMKRAG QPAELAPVYV YLASQESSYV TAEVHGVCGG EHLG
Length:294
Mass (Da):31,488
Last modified:December 20, 2005 - v1
Checksum:i34B8742A16278811
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69170.1.
U00096 Genomic DNA. Translation: AAC76039.1.
AP009048 Genomic DNA. Translation: BAE77062.1.
M28819 Genomic DNA. No translation available.
PIRiA65087.
RefSeqiNP_417476.1. NC_000913.3.
WP_000018760.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76039; AAC76039; b3003.
BAE77062; BAE77062; BAE77062.
GeneIDi947478.
KEGGiecj:JW2972.
eco:b3003.
PATRICi32121424. VBIEscCol129921_3099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69170.1.
U00096 Genomic DNA. Translation: AAC76039.1.
AP009048 Genomic DNA. Translation: BAE77062.1.
M28819 Genomic DNA. No translation available.
PIRiA65087.
RefSeqiNP_417476.1. NC_000913.3.
WP_000018760.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AG84.
SMRiP0AG84. Positions 3-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261414. 14 interactions.
DIPiDIP-36027N.
IntActiP0AG84. 6 interactions.
MINTiMINT-1264908.
STRINGi511145.b3003.

Proteomic databases

EPDiP0AG84.
PaxDbiP0AG84.
PRIDEiP0AG84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76039; AAC76039; b3003.
BAE77062; BAE77062; BAE77062.
GeneIDi947478.
KEGGiecj:JW2972.
eco:b3003.
PATRICi32121424. VBIEscCol129921_3099.

Organism-specific databases

EchoBASEiEB1269.
EcoGeneiEG11292. yghA.

Phylogenomic databases

eggNOGiENOG4105CYX. Bacteria.
ENOG410XNUN. LUCA.
InParanoidiP0AG84.
OMAiAYEGNEQ.
OrthoDBiEOG6N3CR8.
PhylomeDBiP0AG84.

Enzyme and pathway databases

BioCyciEcoCyc:EG11292-MONOMER.
ECOL316407:JW2972-MONOMER.

Miscellaneous databases

PROiP0AG84.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Import of biopolymers into Escherichia coli: nucleotide sequences of the exbB and exbD genes are homologous to those of the tolQ and tolR genes, respectively."
    Eick-Helmerich K., Braun V.
    J. Bacteriol. 171:5117-5126(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 247-294.
    Strain: K12.
  4. "Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli."
    Zhang J., Sprung R., Pei J., Tan X., Kim S., Zhu H., Liu C.F., Grishin N.V., Zhao Y.
    Mol. Cell. Proteomics 8:215-225(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-39, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: K12 / JW1106 and K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYGHA_ECOLI
AccessioniPrimary (citable) accession number: P0AG84
Secondary accession number(s): P25887, Q2M9J4, Q46852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.