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P0AG43

- RIBF_SHIFL

UniProt

P0AG43 - RIBF_SHIFL

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Protein

Riboflavin biosynthesis protein RibF

Gene

ribF

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + riboflavin = ADP + FMN.
ATP + FMN = diphosphate + FAD.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. FMN adenylyltransferase activity Source: UniProtKB-EC
  3. riboflavin kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. FAD biosynthetic process Source: UniProtKB-UniPathway
  2. FMN biosynthetic process Source: UniProtKB-UniPathway
  3. riboflavin biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-843-MONOMER.
UniPathwayiUPA00276; UER00406.
UPA00277; UER00407.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin biosynthesis protein RibF
Including the following 2 domains:
Riboflavin kinase (EC:2.7.1.26)
Alternative name(s):
Flavokinase
FMN adenylyltransferase (EC:2.7.7.2)
Alternative name(s):
FAD pyrophosphorylase
FAD synthase
Gene namesi
Name:ribF
Ordered Locus Names:SF0021, S0024
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Riboflavin biosynthesis protein RibFPRO_0000194143Add
BLAST

Proteomic databases

PaxDbiP0AG43.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF0021.

Structurei

3D structure databases

ProteinModelPortaliP0AG43.
SMRiP0AG43. Positions 19-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RibF family.Curated

Phylogenomic databases

eggNOGiCOG0196.
HOGENOMiHOG000006845.
KOiK11753.
OMAiGVASFGC.
OrthoDBiEOG6QP0ZV.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR015864. FAD_synthase.
IPR023468. Riboflavin_kinase.
IPR002606. Riboflavin_kinase_bac.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR22749. PTHR22749. 1 hit.
PfamiPF06574. FAD_syn. 1 hit.
PF01687. Flavokinase. 1 hit.
[Graphical view]
PIRSFiPIRSF004491. FAD_Synth. 1 hit.
SMARTiSM00904. Flavokinase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.
TIGRFAMsiTIGR00083. ribF. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AG43-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLIRGIHNL SQAPQEGCVL TIGNFDGVHR GHRALLQGLQ EEGRKRNLPV
60 70 80 90 100
MVMLFEPQPL ELFATDKAPA RLTRLREKLR YLAECGVDYV LCVRFDRRFA
110 120 130 140 150
ALTAQNFISD LLVKHLRVKF LAVGDDFRFG AGREGDFLLL QKAGMEYGFD
160 170 180 190 200
ITSTQTFCEG GVRISSTAVR QALADDNLAL AESLLGHPFA ISGRVVHGDE
210 220 230 240 250
LGRTIGFPTA NVPLRRQVSP VKGVYAVEVL GLGEKPLPGV ANIGTRPTVA
260 270 280 290 300
GIRQQLEVHL LDVAMDLYGR HIQVVLRKKI RNEQRFASLD ELKAQIARDE
310
LTAREFFGLT KPA
Length:313
Mass (Da):34,734
Last modified:December 20, 2005 - v1
Checksum:iC0B2EF5499CD30FE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN41687.1.
AE014073 Genomic DNA. Translation: AAP15569.1.
RefSeqiNP_705980.1. NC_004337.2.
NP_835764.1. NC_004741.1.

Genome annotation databases

EnsemblBacteriaiAAN41687; AAN41687; SF0021.
AAP15569; AAP15569; S0024.
GeneIDi1024592.
1076481.
KEGGisfl:SF0021.
sfx:S0024.
PATRICi18700966. VBIShiFle31049_0025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN41687.1 .
AE014073 Genomic DNA. Translation: AAP15569.1 .
RefSeqi NP_705980.1. NC_004337.2.
NP_835764.1. NC_004741.1.

3D structure databases

ProteinModelPortali P0AG43.
SMRi P0AG43. Positions 19-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198214.SF0021.

Proteomic databases

PaxDbi P0AG43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN41687 ; AAN41687 ; SF0021 .
AAP15569 ; AAP15569 ; S0024 .
GeneIDi 1024592.
1076481.
KEGGi sfl:SF0021.
sfx:S0024.
PATRICi 18700966. VBIShiFle31049_0025.

Phylogenomic databases

eggNOGi COG0196.
HOGENOMi HOG000006845.
KOi K11753.
OMAi GVASFGC.
OrthoDBi EOG6QP0ZV.

Enzyme and pathway databases

UniPathwayi UPA00276 ; UER00406 .
UPA00277 ; UER00407 .
BioCyci RETL1328306-WGS:GSTH-843-MONOMER.

Family and domain databases

Gene3Di 2.40.30.30. 1 hit.
3.40.50.620. 1 hit.
InterProi IPR015864. FAD_synthase.
IPR023468. Riboflavin_kinase.
IPR002606. Riboflavin_kinase_bac.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR22749. PTHR22749. 1 hit.
Pfami PF06574. FAD_syn. 1 hit.
PF01687. Flavokinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004491. FAD_Synth. 1 hit.
SMARTi SM00904. Flavokinase. 1 hit.
[Graphical view ]
SUPFAMi SSF82114. SSF82114. 1 hit.
TIGRFAMsi TIGR00083. ribF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiRIBF_SHIFL
AccessioniPrimary (citable) accession number: P0AG43
Secondary accession number(s): P08391, P75621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: December 20, 2005
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3