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Protein

Riboflavin biosynthesis protein RibF

Gene

ribF

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + riboflavin = ADP + FMN.
ATP + FMN = diphosphate + FAD.

Pathwayi: FAD biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FAD from FMN.
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin biosynthesis protein RibF (ribF), Riboflavin biosynthesis protein (CBW45_16175), Riboflavin biosynthesis protein (CBL21_15510)
This subpathway is part of the pathway FAD biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FAD from FMN, the pathway FAD biosynthesis and in Cofactor biosynthesis.

Pathwayi: FMN biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FMN from riboflavin (ATP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Riboflavin biosynthesis protein RibF (ribF), Riboflavin biosynthesis protein (CBW45_16175), Riboflavin biosynthesis protein (CBL21_15510)
This subpathway is part of the pathway FMN biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FMN from riboflavin (ATP route), the pathway FMN biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Nucleotidyltransferase, Transferase
LigandATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00276; UER00406.
UPA00277; UER00407.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin biosynthesis protein RibF
Including the following 2 domains:
Riboflavin kinase (EC:2.7.1.26)
Alternative name(s):
Flavokinase
FMN adenylyltransferase (EC:2.7.7.2)
Alternative name(s):
FAD pyrophosphorylase
FAD synthase
Gene namesi
Name:ribF
Ordered Locus Names:SF0021, S0024
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941431 – 313Riboflavin biosynthesis protein RibFAdd BLAST313

Proteomic databases

PaxDbiP0AG43.
PRIDEiP0AG43.

Structurei

3D structure databases

ProteinModelPortaliP0AG43.
SMRiP0AG43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RibF family.Curated

Phylogenomic databases

eggNOGiENOG4105DTN. Bacteria.
COG0196. LUCA.
HOGENOMiHOG000006845.
KOiK11753.
OMAiHRGHQAI.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
3.40.50.620. 1 hit.
InterProiView protein in InterPro
IPR015864. FAD_synthase.
IPR023468. Riboflavin_kinase.
IPR002606. Riboflavin_kinase_bac.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_dom_sf.
IPR014729. Rossmann-like_a/b/a_fold.
PANTHERiPTHR22749. PTHR22749. 1 hit.
PfamiView protein in Pfam
PF06574. FAD_syn. 1 hit.
PF01687. Flavokinase. 1 hit.
PIRSFiPIRSF004491. FAD_Synth. 1 hit.
SMARTiView protein in SMART
SM00904. Flavokinase. 1 hit.
SUPFAMiSSF82114. SSF82114. 1 hit.
TIGRFAMsiTIGR00083. ribF. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AG43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLIRGIHNL SQAPQEGCVL TIGNFDGVHR GHRALLQGLQ EEGRKRNLPV
60 70 80 90 100
MVMLFEPQPL ELFATDKAPA RLTRLREKLR YLAECGVDYV LCVRFDRRFA
110 120 130 140 150
ALTAQNFISD LLVKHLRVKF LAVGDDFRFG AGREGDFLLL QKAGMEYGFD
160 170 180 190 200
ITSTQTFCEG GVRISSTAVR QALADDNLAL AESLLGHPFA ISGRVVHGDE
210 220 230 240 250
LGRTIGFPTA NVPLRRQVSP VKGVYAVEVL GLGEKPLPGV ANIGTRPTVA
260 270 280 290 300
GIRQQLEVHL LDVAMDLYGR HIQVVLRKKI RNEQRFASLD ELKAQIARDE
310
LTAREFFGLT KPA
Length:313
Mass (Da):34,734
Last modified:December 20, 2005 - v1
Checksum:iC0B2EF5499CD30FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN41687.1.
AE014073 Genomic DNA. Translation: AAP15569.1.
RefSeqiNP_705980.1. NC_004337.2.
WP_000767329.1. NZ_NMXZ01000008.1.

Genome annotation databases

EnsemblBacteriaiAAN41687; AAN41687; SF0021.
AAP15569; AAP15569; S0024.
GeneIDi1024592.
KEGGisfl:SF0021.
sfx:S0024.
PATRICifig|198214.7.peg.24.

Similar proteinsi

Entry informationi

Entry nameiRIBF_SHIFL
AccessioniPrimary (citable) accession number: P0AG43
Secondary accession number(s): P08391, P75621
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: December 20, 2005
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families