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P0AG42

- RIBF_ECO57

UniProt

P0AG42 - RIBF_ECO57

Protein

Riboflavin biosynthesis protein RibF

Gene

ribF

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + riboflavin = ADP + FMN.
    ATP + FMN = diphosphate + FAD.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. FMN adenylyltransferase activity Source: UniProtKB-EC
    3. riboflavin kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. FAD biosynthetic process Source: UniProtKB-UniPathway
    2. FMN biosynthetic process Source: UniProtKB-UniPathway
    3. riboflavin biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-26-MONOMER.
    ECOO157:RIBF-MONOMER.
    UniPathwayiUPA00276; UER00406.
    UPA00277; UER00407.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin biosynthesis protein RibF
    Including the following 2 domains:
    Riboflavin kinase (EC:2.7.1.26)
    Alternative name(s):
    Flavokinase
    FMN adenylyltransferase (EC:2.7.7.2)
    Alternative name(s):
    FAD pyrophosphorylase
    FAD synthase
    Gene namesi
    Name:ribF
    Ordered Locus Names:Z0029, ECs0028
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Riboflavin biosynthesis protein RibFPRO_0000194138Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1256494.
    STRINGi155864.Z0029.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AG42.
    SMRiP0AG42. Positions 19-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RibF family.Curated

    Phylogenomic databases

    eggNOGiCOG0196.
    HOGENOMiHOG000006845.
    KOiK11753.
    OMAiGVASFGC.
    OrthoDBiEOG6QP0ZV.

    Family and domain databases

    Gene3Di2.40.30.30. 1 hit.
    3.40.50.620. 1 hit.
    InterProiIPR015864. FAD_synthase.
    IPR023468. Riboflavin_kinase.
    IPR002606. Riboflavin_kinase_bac.
    IPR015865. Riboflavin_kinase_bac/euk.
    IPR023465. Riboflavin_kinase_domain.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR22749. PTHR22749. 1 hit.
    PfamiPF06574. FAD_syn. 1 hit.
    PF01687. Flavokinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004491. FAD_Synth. 1 hit.
    SMARTiSM00904. Flavokinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF82114. SSF82114. 1 hit.
    TIGRFAMsiTIGR00083. ribF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0AG42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLIRGIHNL SQAPQEGCVL TIGNFDGVHR GHRALLQGLQ EEGRKRNLPV    50
    MVMLFEPQPL ELFATDKAPA RLTRLREKLR YLAECGVDYV LCVRFDRRFA 100
    ALTAQNFISD LLVKHLRVKF LAVGDDFRFG AGREGDFLLL QKAGMEYGFD 150
    ITSTQTFCEG GVRISSTAVR QALADDNLAL AESLLGHPFA ISGRVVHGDE 200
    LGRTIGFPTA NVPLRRQVSP VKGVYAVEVL GLGEKPLPGV ANIGTRPTVA 250
    GIRQQLEVHL LDVAMDLYGR HIQVVLRKKI RNEQRFASLD ELKAQIARDE 300
    LTAREFFGLT KPA 313
    Length:313
    Mass (Da):34,734
    Last modified:December 20, 2005 - v1
    Checksum:iC0B2EF5499CD30FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG54327.1.
    BA000007 Genomic DNA. Translation: BAB33451.1.
    PIRiC85483.
    D90632.
    RefSeqiNP_285719.1. NC_002655.2.
    NP_308055.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG54327; AAG54327; Z0029.
    BAB33451; BAB33451; BAB33451.
    GeneIDi913423.
    956690.
    KEGGiece:Z0029.
    ecs:ECs0028.
    PATRICi18348988. VBIEscCol44059_0024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG54327.1 .
    BA000007 Genomic DNA. Translation: BAB33451.1 .
    PIRi C85483.
    D90632.
    RefSeqi NP_285719.1. NC_002655.2.
    NP_308055.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0AG42.
    SMRi P0AG42. Positions 19-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1256494.
    STRINGi 155864.Z0029.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG54327 ; AAG54327 ; Z0029 .
    BAB33451 ; BAB33451 ; BAB33451 .
    GeneIDi 913423.
    956690.
    KEGGi ece:Z0029.
    ecs:ECs0028.
    PATRICi 18348988. VBIEscCol44059_0024.

    Phylogenomic databases

    eggNOGi COG0196.
    HOGENOMi HOG000006845.
    KOi K11753.
    OMAi GVASFGC.
    OrthoDBi EOG6QP0ZV.

    Enzyme and pathway databases

    UniPathwayi UPA00276 ; UER00406 .
    UPA00277 ; UER00407 .
    BioCyci ECOL386585:GJFA-26-MONOMER.
    ECOO157:RIBF-MONOMER.

    Family and domain databases

    Gene3Di 2.40.30.30. 1 hit.
    3.40.50.620. 1 hit.
    InterProi IPR015864. FAD_synthase.
    IPR023468. Riboflavin_kinase.
    IPR002606. Riboflavin_kinase_bac.
    IPR015865. Riboflavin_kinase_bac/euk.
    IPR023465. Riboflavin_kinase_domain.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR22749. PTHR22749. 1 hit.
    Pfami PF06574. FAD_syn. 1 hit.
    PF01687. Flavokinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004491. FAD_Synth. 1 hit.
    SMARTi SM00904. Flavokinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82114. SSF82114. 1 hit.
    TIGRFAMsi TIGR00083. ribF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiRIBF_ECO57
    AccessioniPrimary (citable) accession number: P0AG42
    Secondary accession number(s): P08391, P75621
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3