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Protein

Threonine efflux protein

Gene

rhtC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conducts the efflux of threonine.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:RHTC-MONOMER.
ECOL316407:JW5586-MONOMER.
MetaCyc:RHTC-MONOMER.
RETL1328306-WGS:GSTH-218-MONOMER.

Protein family/group databases

TCDBi2.A.76.1.2. the resistance to homoserine/threonine (rhtb) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine efflux protein
Gene namesi
Name:rhtC
Synonyms:yigJ
Ordered Locus Names:b3823, JW5586
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11468. rhtC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Topological domaini22 – 4322PeriplasmicSequence analysisAdd
BLAST
Transmembranei44 – 6421HelicalSequence analysisAdd
BLAST
Topological domaini65 – 662CytoplasmicSequence analysis
Transmembranei67 – 8721HelicalSequence analysisAdd
BLAST
Topological domaini88 – 14962PeriplasmicSequence analysisAdd
BLAST
Transmembranei150 – 17324HelicalSequence analysisAdd
BLAST
Topological domaini174 – 20633CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Threonine efflux proteinPRO_0000094736Add
BLAST

Proteomic databases

PaxDbiP0AG38.

Interactioni

Protein-protein interaction databases

BioGridi4263363. 6 interactions.
STRINGi511145.b3823.

Structurei

3D structure databases

ProteinModelPortaliP0AG38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rht family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CCF. Bacteria.
COG1280. LUCA.
HOGENOMiHOG000122945.
InParanoidiP0AG38.
KOiK05835.
OMAiIVMKNTI.
PhylomeDBiP0AG38.

Family and domain databases

InterProiIPR004778. Homoserine/Threonine_efflux.
IPR001123. LysE-type.
[Graphical view]
PANTHERiPTHR30086. PTHR30086. 1 hit.
PfamiPF01810. LysE. 1 hit.
[Graphical view]
PIRSFiPIRSF006324. LeuE. 1 hit.
TIGRFAMsiTIGR00949. 2A76. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AG38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMLFLTVAM VHIVALMSPG PDFFFVSQTA VSRSRKEAMM GVLGITCGVM
60 70 80 90 100
VWAGIALLGL HLIIEKMAWL HTLIMVGGGL YLCWMGYQML RGALKKEAVS
110 120 130 140 150
APAPQVELAK SGRSFLKGLL TNLANPKAII YFGSVFSLFV GDNVGTTARW
160 170 180 190 200
GIFALIIVET LAWFTVVASL FALPQMRRGY QRLAKWIDGF AGALFAGFGI

HLIISR
Length:206
Mass (Da):22,474
Last modified:December 20, 2005 - v1
Checksum:iF64017878CC6D50D
GO

Sequence cautioni

The sequence AAA67619 differs from that shown. Reason: Frameshift at positions 80 and 118. Curated
The sequence M30198 differs from that shown. Reason: Frameshift at positions 47 and 73. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87049 Genomic DNA. Translation: AAA67619.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48222.1.
AP009048 Genomic DNA. Translation: BAE77478.1.
M30198 Genomic DNA. No translation available.
RefSeqiWP_000928824.1. NZ_LN832404.1.
YP_026264.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48222; AAT48222; b3823.
BAE77478; BAE77478; BAE77478.
GeneIDi948317.
KEGGiecj:JW5586.
eco:b3823.
PATRICi32123147. VBIEscCol129921_3939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87049 Genomic DNA. Translation: AAA67619.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48222.1.
AP009048 Genomic DNA. Translation: BAE77478.1.
M30198 Genomic DNA. No translation available.
RefSeqiWP_000928824.1. NZ_LN832404.1.
YP_026264.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP0AG38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263363. 6 interactions.
STRINGi511145.b3823.

Protein family/group databases

TCDBi2.A.76.1.2. the resistance to homoserine/threonine (rhtb) family.

Proteomic databases

PaxDbiP0AG38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48222; AAT48222; b3823.
BAE77478; BAE77478; BAE77478.
GeneIDi948317.
KEGGiecj:JW5586.
eco:b3823.
PATRICi32123147. VBIEscCol129921_3939.

Organism-specific databases

EchoBASEiEB1436.
EcoGeneiEG11468. rhtC.

Phylogenomic databases

eggNOGiENOG4105CCF. Bacteria.
COG1280. LUCA.
HOGENOMiHOG000122945.
InParanoidiP0AG38.
KOiK05835.
OMAiIVMKNTI.
PhylomeDBiP0AG38.

Enzyme and pathway databases

BioCyciEcoCyc:RHTC-MONOMER.
ECOL316407:JW5586-MONOMER.
MetaCyc:RHTC-MONOMER.
RETL1328306-WGS:GSTH-218-MONOMER.

Miscellaneous databases

PROiP0AG38.

Family and domain databases

InterProiIPR004778. Homoserine/Threonine_efflux.
IPR001123. LysE-type.
[Graphical view]
PANTHERiPTHR30086. PTHR30086. 1 hit.
PfamiPF01810. LysE. 1 hit.
[Graphical view]
PIRSFiPIRSF006324. LeuE. 1 hit.
TIGRFAMsiTIGR00949. 2A76. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHTC_ECOLI
AccessioniPrimary (citable) accession number: P0AG38
Secondary accession number(s): P27846, Q2M8C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.