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Protein

Homoserine/homoserine lactone efflux protein

Gene

rhtB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conducts the efflux of homoserine and homoserine lactone.1 Publication

GO - Molecular functioni

  • homoserine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • homoserine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:RHTB-MONOMER.
ECOL316407:JW5585-MONOMER.
MetaCyc:RHTB-MONOMER.
RETL1328306-WGS:GSTH-3609-MONOMER.

Protein family/group databases

TCDBi2.A.76.1.1. the resistance to homoserine/threonine (rhtb) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine/homoserine lactone efflux protein
Gene namesi
Name:rhtB
Synonyms:yigK
Ordered Locus Names:b3824, JW5585
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11469. rhtB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence analysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Homoserine/homoserine lactone efflux proteinPRO_0000094730Add
BLAST

Proteomic databases

PaxDbiP0AG34.
PRIDEiP0AG34.

Interactioni

Protein-protein interaction databases

BioGridi4259612. 9 interactions.
STRINGi511145.b3824.

Structurei

3D structure databases

ProteinModelPortaliP0AG34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the rht family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410829K. Bacteria.
COG1280. LUCA.
HOGENOMiHOG000122945.
InParanoidiP0AG34.
KOiK05834.
OMAiICGLQLG.
PhylomeDBiP0AG34.

Family and domain databases

InterProiIPR004778. Homoserine/Threonine_efflux.
IPR001123. LysE-type.
[Graphical view]
PANTHERiPTHR30086. PTHR30086. 1 hit.
PfamiPF01810. LysE. 1 hit.
[Graphical view]
PIRSFiPIRSF006324. LeuE. 1 hit.
TIGRFAMsiTIGR00949. 2A76. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AG34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEWWFAYL LTSIILSLSP GSGAINTMTT SLNHGYRGAV ASIAGLQTGL
60 70 80 90 100
AIHIVLVGVG LGTLFSRSVI AFEVLKWAGA AYLIWLGIQQ WRAAGAIDLK
110 120 130 140 150
SLASTQSRRH LFQRAVFVNL TNPKSIVFLA ALFPQFIMPQ QPQLMQYIVL
160 170 180 190 200
GVTTIVVDII VMIGYATLAQ RIALWIKGPK QMKALNKIFG SLFMLVGALL

ASARHA
Length:206
Mass (Da):22,427
Last modified:December 20, 2005 - v1
Checksum:i1164F17738509C8C
GO

Sequence cautioni

The sequence AAA67620 differs from that shown. Reason: Frameshift at position 60. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87049 Genomic DNA. Translation: AAA67620.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48223.1.
AP009048 Genomic DNA. Translation: BAE77477.1.
RefSeqiWP_000171710.1. NZ_LN832404.1.
YP_026265.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48223; AAT48223; b3824.
BAE77477; BAE77477; BAE77477.
GeneIDi948316.
KEGGiecj:JW5585.
eco:b3824.
PATRICi32123149. VBIEscCol129921_3940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87049 Genomic DNA. Translation: AAA67620.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48223.1.
AP009048 Genomic DNA. Translation: BAE77477.1.
RefSeqiWP_000171710.1. NZ_LN832404.1.
YP_026265.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP0AG34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259612. 9 interactions.
STRINGi511145.b3824.

Protein family/group databases

TCDBi2.A.76.1.1. the resistance to homoserine/threonine (rhtb) family.

Proteomic databases

PaxDbiP0AG34.
PRIDEiP0AG34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48223; AAT48223; b3824.
BAE77477; BAE77477; BAE77477.
GeneIDi948316.
KEGGiecj:JW5585.
eco:b3824.
PATRICi32123149. VBIEscCol129921_3940.

Organism-specific databases

EchoBASEiEB1437.
EcoGeneiEG11469. rhtB.

Phylogenomic databases

eggNOGiENOG410829K. Bacteria.
COG1280. LUCA.
HOGENOMiHOG000122945.
InParanoidiP0AG34.
KOiK05834.
OMAiICGLQLG.
PhylomeDBiP0AG34.

Enzyme and pathway databases

BioCyciEcoCyc:RHTB-MONOMER.
ECOL316407:JW5585-MONOMER.
MetaCyc:RHTB-MONOMER.
RETL1328306-WGS:GSTH-3609-MONOMER.

Miscellaneous databases

PROiP0AG34.

Family and domain databases

InterProiIPR004778. Homoserine/Threonine_efflux.
IPR001123. LysE-type.
[Graphical view]
PANTHERiPTHR30086. PTHR30086. 1 hit.
PfamiPF01810. LysE. 1 hit.
[Graphical view]
PIRSFiPIRSF006324. LeuE. 1 hit.
TIGRFAMsiTIGR00949. 2A76. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHTB_ECOLI
AccessioniPrimary (citable) accession number: P0AG34
Secondary accession number(s): P27847, Q2M8C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.