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Protein

Homoserine/homoserine lactone efflux protein

Gene

rhtB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conducts the efflux of homoserine and homoserine lactone.1 Publication

GO - Molecular functioni

  • homoserine transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • homoserine transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:RHTB-MONOMER
MetaCyc:RHTB-MONOMER

Protein family/group databases

TCDBi2.A.76.1.1 the resistance to homoserine/threonine (rhtb) family

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine/homoserine lactone efflux protein
Gene namesi
Name:rhtB
Synonyms:yigK
Ordered Locus Names:b3824, JW5585
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11469 rhtB

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947301 – 206Homoserine/homoserine lactone efflux proteinAdd BLAST206

Proteomic databases

PaxDbiP0AG34
PRIDEiP0AG34

Interactioni

Protein-protein interaction databases

BioGridi4259612, 20 interactors
STRINGi316385.ECDH10B_4015

Structurei

3D structure databases

ProteinModelPortaliP0AG34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rht family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410829K Bacteria
COG1280 LUCA
HOGENOMiHOG000122945
InParanoidiP0AG34
KOiK05834
OMAiGWIKGPK
PhylomeDBiP0AG34

Family and domain databases

InterProiView protein in InterPro
IPR004778 Homoserine/Threonine_efflux
IPR001123 LeuE-type
PANTHERiPTHR30086 PTHR30086, 1 hit
PfamiView protein in Pfam
PF01810 LysE, 1 hit
PIRSFiPIRSF006324 LeuE, 1 hit
TIGRFAMsiTIGR00949 2A76, 1 hit

Sequencei

Sequence statusi: Complete.

P0AG34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEWWFAYL LTSIILSLSP GSGAINTMTT SLNHGYRGAV ASIAGLQTGL
60 70 80 90 100
AIHIVLVGVG LGTLFSRSVI AFEVLKWAGA AYLIWLGIQQ WRAAGAIDLK
110 120 130 140 150
SLASTQSRRH LFQRAVFVNL TNPKSIVFLA ALFPQFIMPQ QPQLMQYIVL
160 170 180 190 200
GVTTIVVDII VMIGYATLAQ RIALWIKGPK QMKALNKIFG SLFMLVGALL

ASARHA
Length:206
Mass (Da):22,427
Last modified:December 20, 2005 - v1
Checksum:i1164F17738509C8C
GO

Sequence cautioni

The sequence AAA67620 differs from that shown. Reason: Frameshift at position 60.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87049 Genomic DNA Translation: AAA67620.1 Frameshift.
U00096 Genomic DNA Translation: AAT48223.1
AP009048 Genomic DNA Translation: BAE77477.1
RefSeqiWP_000171710.1, NZ_LN832404.1
YP_026265.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48223; AAT48223; b3824
BAE77477; BAE77477; BAE77477
GeneIDi948316
KEGGiecj:JW5585
eco:b3824
PATRICifig|1411691.4.peg.2883

Entry informationi

Entry nameiRHTB_ECOLI
AccessioniPrimary (citable) accession number: P0AG34
Secondary accession number(s): P27847, Q2M8C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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