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P0AG33

- RHO_SHIFL

UniProt

P0AG33 - RHO_SHIFL

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Protein
Transcription termination factor Rho
Gene
rho, SF3856, S3903
Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei212 – 2121ATP By similarity
Sitei326 – 3261RNA-binding 2 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 1746ATP Reviewed prediction
Nucleotide bindingi181 – 1866ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. RNA-dependent ATPase activity Source: InterPro
  4. helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor Rho (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase Rho
Gene namesi
Name:rho
Ordered Locus Names:SF3856, S3903
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Transcription termination factor RhoUniRule annotation
PRO_0000188978Add
BLAST

Proteomic databases

PaxDbiP0AG33.
PRIDEiP0AG33.

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure By similarity.

Protein-protein interaction databases

STRINGi198214.SF3856.

Structurei

3D structure databases

ProteinModelPortaliP0AG33.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 666RNA-binding 1 By similarity
Regioni78 – 803RNA-binding 1 By similarity
Regioni108 – 1103RNA-binding 1 By similarity
Regioni284 – 2885RNA-binding 2 By similarity

Sequence similaritiesi

Belongs to the Rho family.

Phylogenomic databases

eggNOGiCOG1158.
HOGENOMiHOG000076952.
KOiK03628.
OrthoDBiEOG6N681W.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AG33-1 [UniParc]FASTAAdd to Basket

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MNLTELKNTP VSELITLGEN MGLENLARMR KQDIIFAILK QHAKSGEDIF    50
GDGVLEILQD GFGFLRSADS SYLAGPDDIY VSPSQIRRFN LRTGDTISGK 100
IRPPKEGERY FALLKVNEVN FDKPENARNK ILFENLTPLH ANSRLRMERG 150
NGSTEDLTAR VLDLASPIGR GQRGLIVAPP KAGKTMLLQN IAQSIAYNHP 200
DCVLMVLLID ERPEEVTEMQ RLVKGEVVAS TFDEPASRHV QVAEMVIEKA 250
KRLVEHKKDV IILLDSITRL ARAYNTVVPA SGKVLTGGVD ANALHRPKRF 300
FGAARNVEEG GSLTIIATAL IDTGSKMDEV IYEEFKGTGN MELHLSRKIA 350
EKRVFPAIDY NRSGTRKEEL LTTQEELQKM WILRKIIHPM GEIDAMEFLI 400
NKLAMTKTND DFFEMMKRS 419
Length:419
Mass (Da):47,004
Last modified:July 21, 1986 - v1
Checksum:i5970A85334C43467
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN45293.2.
AE014073 Genomic DNA. Translation: AAP18904.1.
RefSeqiNP_709586.2. NC_004337.2.
NP_839093.1. NC_004741.1.

Genome annotation databases

EnsemblBacteriaiAAN45293; AAN45293; SF3856.
AAP18904; AAP18904; S3903.
GeneIDi1025988.
1076538.
KEGGisfl:SF3856.
sfx:S3903.
PATRICi18709682. VBIShiFle31049_4256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN45293.2 .
AE014073 Genomic DNA. Translation: AAP18904.1 .
RefSeqi NP_709586.2. NC_004337.2.
NP_839093.1. NC_004741.1.

3D structure databases

ProteinModelPortali P0AG33.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198214.SF3856.

Proteomic databases

PaxDbi P0AG33.
PRIDEi P0AG33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN45293 ; AAN45293 ; SF3856 .
AAP18904 ; AAP18904 ; S3903 .
GeneIDi 1025988.
1076538.
KEGGi sfl:SF3856.
sfx:S3903.
PATRICi 18709682. VBIShiFle31049_4256.

Phylogenomic databases

eggNOGi COG1158.
HOGENOMi HOG000076952.
KOi K03628.
OrthoDBi EOG6N681W.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01884. Rho.
InterProi IPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsi TIGR00767. rho. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiRHO_SHIFL
AccessioniPrimary (citable) accession number: P0AG33
Secondary accession number(s): P03002, Q48357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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