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Protein

Transcription termination factor Rho

Gene

rho

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei212ATPUniRule annotation1
Sitei326RNA-binding 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 174ATPUniRule annotation6
Nucleotide bindingi181 – 186ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processTranscription, Transcription regulation, Transcription termination
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
Gene namesi
Name:rhoUniRule annotation
Ordered Locus Names:SF3856, S3903
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001889781 – 419Transcription termination factor RhoAdd BLAST419

Proteomic databases

PRIDEiP0AG33

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP0AG33
SMRiP0AG33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 123Rho RNA-BDPROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 66RNA-binding 1UniRule annotation6
Regioni78 – 80RNA-binding 1UniRule annotation3
Regioni108 – 110RNA-binding 1UniRule annotation3
Regioni284 – 288RNA-binding 2UniRule annotation5

Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4P Bacteria
COG1158 LUCA
HOGENOMiHOG000076952
KOiK03628
OMAiDYNYLPG

Family and domain databases

CDDicd04459 Rho_CSD, 1 hit
HAMAPiMF_01884 Rho, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR011129 CSD
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR011112 Rho_N
IPR036269 Rho_N_sf
IPR011113 Rho_RNA-bd
IPR004665 Term_rho
PANTHERiPTHR15184:SF34 PTHR15184:SF34, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF07498 Rho_N, 1 hit
PF07497 Rho_RNA_bind, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00357 CSP, 1 hit
SM00959 Rho_N, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
SSF68912 SSF68912, 1 hit
TIGRFAMsiTIGR00767 rho, 1 hit
PROSITEiView protein in PROSITE
PS51856 RHO_RNA_BD, 1 hit

Sequencei

Sequence statusi: Complete.

P0AG33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLTELKNTP VSELITLGEN MGLENLARMR KQDIIFAILK QHAKSGEDIF
60 70 80 90 100
GDGVLEILQD GFGFLRSADS SYLAGPDDIY VSPSQIRRFN LRTGDTISGK
110 120 130 140 150
IRPPKEGERY FALLKVNEVN FDKPENARNK ILFENLTPLH ANSRLRMERG
160 170 180 190 200
NGSTEDLTAR VLDLASPIGR GQRGLIVAPP KAGKTMLLQN IAQSIAYNHP
210 220 230 240 250
DCVLMVLLID ERPEEVTEMQ RLVKGEVVAS TFDEPASRHV QVAEMVIEKA
260 270 280 290 300
KRLVEHKKDV IILLDSITRL ARAYNTVVPA SGKVLTGGVD ANALHRPKRF
310 320 330 340 350
FGAARNVEEG GSLTIIATAL IDTGSKMDEV IYEEFKGTGN MELHLSRKIA
360 370 380 390 400
EKRVFPAIDY NRSGTRKEEL LTTQEELQKM WILRKIIHPM GEIDAMEFLI
410
NKLAMTKTND DFFEMMKRS
Length:419
Mass (Da):47,004
Last modified:July 21, 1986 - v1
Checksum:i5970A85334C43467
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN45293.2
AE014073 Genomic DNA Translation: AAP18904.1
RefSeqiNP_709586.2, NC_004337.2
WP_001054527.1, NZ_NIYV01000124.1

Genome annotation databases

EnsemblBacteriaiAAN45293; AAN45293; SF3856
AAP18904; AAP18904; S3903
GeneIDi1025988
KEGGisfl:SF3856
sfx:S3903
PATRICifig|198214.7.peg.4546

Similar proteinsi

Entry informationi

Entry nameiRHO_SHIFL
AccessioniPrimary (citable) accession number: P0AG33
Secondary accession number(s): P03002, Q48357
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health