Reviewed,
UniProtKB/Swiss-Prot P0AG20 (RELA_ECOLI)
Last modified
June 16, 2009.
Version 30.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: GTP pyrophosphokinase EC=2.7.6.5 Alternative name(s): ATP:GTP 3'-pyrophosphotransferase ppGpp synthetase I (p)ppGpp synthetase | ||||
| Gene names |
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| Organism | Escherichia coli (strain K12) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 83333 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia |
Protein attributes
| Sequence length | 744 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. |
| Catalytic activity | ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. |
| Pathway | Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. |
| Sequence similarities | Belongs to the relA/spoT family. Contains 1 ACT domain. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding GTP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | guanosine tetraphosphate metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP bindingInferred from electronic annotation. Source: UniProtKB-KW GTP diphosphokinase activityInferred from electronic annotation. Source: EC amino acid bindingInferred from electronic annotation. Source: InterPro kinase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| J04039 Unassigned DNA. Translation: AAA03237.1. U29580 Genomic DNA. Translation: AAA69294.1. U00096 Genomic DNA. Translation: AAC75826.1. AP009048 Genomic DNA. Translation: BAE76858.1. | |
| PIR | KIECG. D65060. |
| RefSeq | AP_003350.1. NP_417264.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 947244. |
| GenomeReviews | Gene locus JW2755 in contig AP009048_GR. Gene locus b2784 in contig U00096_GR. |
| KEGG | ecj:JW2755. eco:b2784. |
Organism-specific databases | |
| EchoBASE | EB0828. |
| EcoGene | EG10835. relA. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P0AG20. |
| OMA | P0AG20. DLGHRCR. |
Enzyme and pathway databases | |
| BioCyc | EcoCyc:RELA-MON. MetaCyc:RELA-MON. |
Family and domain databases | |
| InterPro | IPR002912. ACT_bd. IPR012675. b-grasp_ferredoxin-like. IPR007685. RelA_SpoT. IPR004811. SpoT_relA. IPR004095. TGS. [Graphical view] |
| Gene3D | G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. |
| Pfam | PF01842. ACT. 1 hit. PF04607. RelA_SpoT. 1 hit. PF02824. TGS. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00691. spoT_relA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | RELA_ECOLI | ||||||||
| Accession | Primary (citable) accession number: P0AG20 Secondary accession number(s): P11585, Q2MA48 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Escherichia coli Escherichia coli (strain K12): entries and cross-references to EcoGene |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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