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Protein

Ribulose-phosphate 3-epimerase

Gene

rpe

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.By similarity

Catalytic activityi

D-ribulose 5-phosphate = D-xylulose 5-phosphate.

Cofactori

Co2+By similarity, Fe2+By similarity, Mn2+By similarity, Zn2+By similarityNote: Binds 1 divalent metal cation per subunit. Active with Co2+, Fe2+, Mn2+ and Zn2+.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91SubstrateBy similarity
Metal bindingi34 – 341Divalent metal cationBy similarity
Active sitei36 – 361Proton acceptorBy similarity
Metal bindingi36 – 361Divalent metal cationBy similarity
Metal bindingi68 – 681Divalent metal cationBy similarity
Binding sitei68 – 681SubstrateBy similarity
Active sitei177 – 1771Proton donorBy similarity
Metal bindingi177 – 1771Divalent metal cationBy similarity
Binding sitei179 – 1791Substrate; via amide nitrogenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Cobalt, Iron, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4198-MONOMER.
ECOO157:RPE-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose-phosphate 3-epimerase (EC:5.1.3.1)
Alternative name(s):
Pentose-5-phosphate 3-epimerase
Short name:
PPE
R5P3E
Gene namesi
Name:rpe
Ordered Locus Names:Z4739, ECs4228
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Ribulose-phosphate 3-epimerasePRO_0000171569Add
BLAST

Interactioni

Protein-protein interaction databases

MINTiMINT-1228302.
STRINGi155864.Z4739.

Structurei

3D structure databases

ProteinModelPortaliP0AG09.
SMRiP0AG09. Positions 6-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni144 – 1474Substrate bindingBy similarity
Regioni199 – 2002Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DJV. Bacteria.
COG0036. LUCA.
HOGENOMiHOG000259347.
KOiK01783.
OMAiHYEACTH.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01163. rpe. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AG09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQYLIAPSI LSADFARLGE DTAKALAAGA DVVHFDVMDN HYVPNLTIGP
60 70 80 90 100
MVLKSLRNYG ITAPIDVHLM VKPVDRIVPD FAAAGASIIT FHPEASEHVD
110 120 130 140 150
RTLQLIKENG CKAGLVFNPA TPLSYLDYVM DKLDVILLMS VNPGFGGQSF
160 170 180 190 200
IPQTLDKLRE VRRRIDESGF DIRLEVDGGV KVNNIGEIAA AGADMFVAGS
210 220
AIFDQPDYKK VIDEMRSELA KVSHE
Length:225
Mass (Da):24,554
Last modified:December 20, 2005 - v1
Checksum:iDD678085698466FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58486.1.
BA000007 Genomic DNA. Translation: BAB37651.1.
PIRiB86003.
D91157.
RefSeqiNP_312255.1. NC_002695.1.
WP_000816280.1. NZ_LPWC01000263.1.

Genome annotation databases

EnsemblBacteriaiAAG58486; AAG58486; Z4739.
BAB37651; BAB37651; BAB37651.
GeneIDi915917.
KEGGiece:Z4739.
ecs:ECs4228.
PATRICi18358009. VBIEscCol44059_4171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG58486.1.
BA000007 Genomic DNA. Translation: BAB37651.1.
PIRiB86003.
D91157.
RefSeqiNP_312255.1. NC_002695.1.
WP_000816280.1. NZ_LPWC01000263.1.

3D structure databases

ProteinModelPortaliP0AG09.
SMRiP0AG09. Positions 6-222.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1228302.
STRINGi155864.Z4739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG58486; AAG58486; Z4739.
BAB37651; BAB37651; BAB37651.
GeneIDi915917.
KEGGiece:Z4739.
ecs:ECs4228.
PATRICi18358009. VBIEscCol44059_4171.

Phylogenomic databases

eggNOGiENOG4105DJV. Bacteria.
COG0036. LUCA.
HOGENOMiHOG000259347.
KOiK01783.
OMAiHYEACTH.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4198-MONOMER.
ECOO157:RPE-MONOMER.

Family and domain databases

CDDicd00429. RPE. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR026019. Ribul_P_3_epim.
IPR000056. Ribul_P_3_epim-like.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR11749. PTHR11749. 1 hit.
PfamiPF00834. Ribul_P_3_epim. 1 hit.
[Graphical view]
PIRSFiPIRSF001461. RPE. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01163. rpe. 1 hit.
PROSITEiPS01085. RIBUL_P_3_EPIMER_1. 1 hit.
PS01086. RIBUL_P_3_EPIMER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPE_ECO57
AccessioniPrimary (citable) accession number: P0AG09
Secondary accession number(s): P32661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.