Reviewed, UniProtKB/Swiss-Prot P0AG07 (RPE_ECOLI)

Names and origin

Protein names

Recommended name:
    Ribulose-phosphate 3-epimerase
    EC=5.1.3.1
Alternative name(s):
    Pentose-5-phosphate 3-epimerase
      Short name=PPE
    R5P3E

Gene names

Name:	rpe
Synonyms:	dod, yhfD
Ordered Locus Names:	b3386, JW3349

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	D-ribulose 5-phosphate = D-xylulose 5-phosphate.
Sequence similarities	Belongs to the ribulose-phosphate 3-epimerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct ribulose-phosphate 3-epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
dnaN	P0A988	1	EBI-546020,EBI-542385

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Ribulose-phosphate 3-epimerase		PRO_0000171568
Experimental info
	Sequence conflict	203 – 225	23	FDQPD…KVSHE → LTSQTTKKSTMKCAVNWQR in CAA79663. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P0AG07-1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: DD678085698466FA	FASTA	225	24,554
	10 20 30 40 50 60 MKQYLIAPSI LSADFARLGE DTAKALAAGA DVVHFDVMDN HYVPNLTIGP MVLKSLRNYG 70 80 90 100 110 120 ITAPIDVHLM VKPVDRIVPD FAAAGASIIT FHPEASEHVD RTLQLIKENG CKAGLVFNPA 130 140 150 160 170 180 TPLSYLDYVM DKLDVILLMS VNPGFGGQSF IPQTLDKLRE VRRRIDESGF DIRLEVDGGV 190 200 210 220 KVNNIGEIAA AGADMFVAGS AIFDQPDYKK VIDEMRSELA KVSHE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of three genes in the dam-containing operon of Escherichia coli." Lyngstadaas A., Lobner-Olesen A., Boye E. Mol. Gen. Genet. 247:546-554(1995) [PubMed: 7603433] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z19601 Genomic DNA. Translation: CAA79663.1. U18997 Genomic DNA. Translation: AAA58183.1. U00096 Genomic DNA. Translation: AAC76411.1. AP009048 Genomic DNA. Translation: BAE77905.1.
PIR	E65133.
RefSeq	AP_004404.1. NP_417845.1.
3D structure databases
HSSP	HSSP built from PDB template 1RPX based on UniProtKB Q43843.
ModBase	Search...
Protein-protein interaction databases
IntAct	P0AG07. 14 interactions.
Genome annotation databases
GeneID	947896.
GenomeReviews	Gene locus JW3349 in contig AP009048_GR. Gene locus b3386 in contig U00096_GR.
KEGG	ecj:JW3349. eco:b3386.
Organism-specific databases
EchoBASE	EB1903.
EcoGene	EG11960. rpe.
CMR	Search...
Phylogenomic databases
HOGENOM	P0AG07.
OMA	P0AG07. HIDRTLQ.
Enzyme and pathway databases
BioCyc	EcoCyc:RIBULP3EPIM-MON. MetaCyc:RIBULP3EPIM-MON.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR000056. Ribul_P_3_epim. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11749. Ribul_P_3_epim. 1 hit.
Pfam	PF00834. Ribul_P_3_epim. 1 hit. [Graphical view]
TIGRFAMs	TIGR01163. rpe. 1 hit.
PROSITE	PS01085. RIBUL_P_3_EPIMER_1. 1 hit. PS01086. RIBUL_P_3_EPIMER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPE_ECOLI

Accession

Primary (citable) accession number: P0AG07
Secondary accession number(s): P32661, Q2M751

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)