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Protein

Streptomycin 3''-adenylyltransferase

Gene

aadA

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Mediates bacterial resistance to the antibiotics streptomycin and spectomycin.

Catalytic activityi

ATP + streptomycin = diphosphate + 3''-adenylylstreptomycin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processAntibiotic resistance
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Streptomycin 3''-adenylyltransferase (EC:2.7.7.47)
Gene namesi
Name:aadA
Encoded oniPlasmid pCN10 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000685801 – 262Streptomycin 3''-adenylyltransferaseAdd BLAST262

Structurei

3D structure databases

SMRiP0AG06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR025184 DUF4111
IPR002934 Polymerase_NTP_transf_dom
IPR024172 Streptomycin_AdlTfrase
PfamiView protein in Pfam
PF13427 DUF4111, 1 hit
PF01909 NTP_transf_2, 1 hit
PIRSFiPIRSF000819 Streptomycin_3-adenylyltransf, 1 hit

Sequencei

Sequence statusi: Complete.

P0AG06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREAVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL
60 70 80 90 100
LVTVTVRLDE TTRRALINDL LETSASPGES EILRAVEVTI VVHDDIIPWR
110 120 130 140 150
YPAKRELQFG EWQRNDILAG IFEPATIDID LAILLTKARE HSVALVGPAA
160 170 180 190 200
EELFDPVPEQ DLFEALNETL TLWNSPPDWA GDERNVVLTL SRIWYSAVTG
210 220 230 240 250
KIAPKDVAAD WAMERLPAQY QPVILEARQA YLGQEDRLAS RADQLEEFVH
260
YVKGEITKVV GK
Length:262
Mass (Da):29,203
Last modified:December 20, 2005 - v1
Checksum:iA2EEB1DBA6272F33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03886 Genomic DNA Translation: CAA27523.1

Similar proteinsi

Entry informationi

Entry nameiS3AX_SHIFL
AccessioniPrimary (citable) accession number: P0AG06
Secondary accession number(s): P04826
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid
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Main funding by: National Institutes of Health