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Protein

Protein SanA

Gene

sanA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Participates in the barrier function of the cell envelope.

GO - Biological processi

  • response to drug Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG12025-MONOMER.
ECOL316407:JW2132-MONOMER.

Protein family/group databases

TCDBi9.B.114.1.1. the vanomycin-sensitivity protein (sana) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SanA
Gene namesi
Name:sanA
Synonyms:yeiF
Ordered Locus Names:b2144, JW2132
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12025. sanA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence analysis
Transmembranei7 – 2317HelicalSequence analysisAdd
BLAST
Topological domaini24 – 239216PeriplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: EcoCyc
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Protein SanAPRO_0000097576Add
BLAST

Proteomic databases

PaxDbiP0AFY2.
PRIDEiP0AFY2.

Interactioni

Protein-protein interaction databases

BioGridi4259167. 3 interactions.
IntActiP0AFY2. 2 interactions.
STRINGi511145.b2144.

Structurei

3D structure databases

ProteinModelPortaliP0AFY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107GZ4. Bacteria.
COG2949. LUCA.
HOGENOMiHOG000031180.
InParanoidiP0AFY2.
KOiK03748.
OMAiDNAQQSY.
OrthoDBiEOG6WMJ3Z.
PhylomeDBiP0AFY2.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR003848. DUF218.
IPR014729. Rossmann-like_a/b/a_fold.
IPR023604. Uncharacterised_SanA.
[Graphical view]
PfamiPF02698. DUF218. 1 hit.
[Graphical view]
PIRSFiPIRSF005011. SanA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AFY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKRVFLSLL VLIGLLLLTV LGLDRWMSWK TAPYIYDELQ DLPYRQVGVV
60 70 80 90 100
LGTAKYYRTG VINQYYRYRI QGAINAYNSG KVNYLLLSGD NALQSYNEPM
110 120 130 140 150
TMRKDLIAAG VDPSDIVLDY AGFRTLDSIV RTRKVFDTND FIIITQRFHC
160 170 180 190 200
ERALFIALHM GIQAQCYAVP SPKDMLSVRI REFAARFGAL ADLYIFKREP
210 220 230
RFLGPLVPIP AMHQVPEDAQ GYPAVTPEQL LELQKKQGK
Length:239
Mass (Da):27,287
Last modified:December 20, 2005 - v1
Checksum:i574EF9B02249547C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 23984IALHM…KKQGK → MRCIWDSGSVLCRTVTERYA VSTYS (PubMed:8550448).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47804 Genomic DNA. Translation: CAA87766.1.
U00096 Genomic DNA. Translation: AAC75205.1.
AP009048 Genomic DNA. Translation: BAE76621.1.
U00007 Genomic DNA. Translation: AAA60509.1.
M60916 Genomic DNA. No translation available.
PIRiG64982.
RefSeqiNP_416649.1. NC_000913.3.
WP_000920064.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75205; AAC75205; b2144.
BAE76621; BAE76621; BAE76621.
GeneIDi949003.
KEGGiecj:JW2132.
eco:b2144.
PATRICi32119631. VBIEscCol129921_2226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47804 Genomic DNA. Translation: CAA87766.1.
U00096 Genomic DNA. Translation: AAC75205.1.
AP009048 Genomic DNA. Translation: BAE76621.1.
U00007 Genomic DNA. Translation: AAA60509.1.
M60916 Genomic DNA. No translation available.
PIRiG64982.
RefSeqiNP_416649.1. NC_000913.3.
WP_000920064.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AFY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259167. 3 interactions.
IntActiP0AFY2. 2 interactions.
STRINGi511145.b2144.

Protein family/group databases

TCDBi9.B.114.1.1. the vanomycin-sensitivity protein (sana) family.

Proteomic databases

PaxDbiP0AFY2.
PRIDEiP0AFY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75205; AAC75205; b2144.
BAE76621; BAE76621; BAE76621.
GeneIDi949003.
KEGGiecj:JW2132.
eco:b2144.
PATRICi32119631. VBIEscCol129921_2226.

Organism-specific databases

EchoBASEiEB1960.
EcoGeneiEG12025. sanA.

Phylogenomic databases

eggNOGiENOG4107GZ4. Bacteria.
COG2949. LUCA.
HOGENOMiHOG000031180.
InParanoidiP0AFY2.
KOiK03748.
OMAiDNAQQSY.
OrthoDBiEOG6WMJ3Z.
PhylomeDBiP0AFY2.

Enzyme and pathway databases

BioCyciEcoCyc:EG12025-MONOMER.
ECOL316407:JW2132-MONOMER.

Miscellaneous databases

PROiP0AFY2.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR003848. DUF218.
IPR014729. Rossmann-like_a/b/a_fold.
IPR023604. Uncharacterised_SanA.
[Graphical view]
PfamiPF02698. DUF218. 1 hit.
[Graphical view]
PIRSFiPIRSF005011. SanA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Amplification of a novel gene, sanA, abolishes a vancomycin-sensitive defect in Escherichia coli."
    Rida S., Caillet J., Alix J.-H.
    J. Bacteriol. 178:94-102(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K., Church G.M.
    Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-152.
    Strain: K12 / BHB2600.
  5. "Cloning and nucleotide sequence of the Escherichia coli cytidine deaminase (ccd) gene."
    Yang C., Carlow D., Wolfenden R., Short S.A.
    Biochemistry 31:4168-4174(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-55.

Entry informationi

Entry nameiSANA_ECOLI
AccessioniPrimary (citable) accession number: P0AFY2
Secondary accession number(s): P33017, P76438, Q2MAT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.