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Protein

Regulator of nucleoside diphosphate kinase

Gene

rnk

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as an anti-Gre factor. Regulates the level of the nucleoside diphosphate kinase Ndk.UniRule annotation2 Publications

Miscellaneous

Can restore alginate synthesis and Ndk activity in the aglQ mutant of P.aeruginosa.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyciEcoCyc:G6337-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of nucleoside diphosphate kinaseUniRule annotation
Gene namesi
Name:rnkUniRule annotation
Ordered Locus Names:b0610, JW0602
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12637 rnk

Pathology & Biotechi

Disruption phenotypei

Mutant shows a significant reduction in the level of Ndk.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000973861 – 136Regulator of nucleoside diphosphate kinaseAdd BLAST136

Proteomic databases

EPDiP0AFW4
PaxDbiP0AFW4
PRIDEiP0AFW4

Interactioni

Subunit structurei

Interacts with the RNA polymerase.UniRule annotation1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4259900, 11 interactors
DIPiDIP-48048N
IntActiP0AFW4, 28 interactors
STRINGi316385.ECDH10B_0678

Structurei

Secondary structure

1136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Helixi10 – 21Combined sources12
Helixi23 – 25Combined sources3
Helixi29 – 39Combined sources11
Beta strandi42 – 44Combined sources3
Helixi46 – 48Combined sources3
Beta strandi59 – 64Combined sources6
Turni65 – 67Combined sources3
Beta strandi70 – 76Combined sources7
Helixi78 – 80Combined sources3
Turni84 – 86Combined sources3
Beta strandi87 – 89Combined sources3
Helixi93 – 98Combined sources6
Beta strandi106 – 111Combined sources6
Turni112 – 114Combined sources3
Beta strandi115 – 126Combined sources12
Turni128 – 132Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BMBX-ray1.91A/B1-136[»]
ProteinModelPortaliP0AFW4
SMRiP0AFW4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AFW4

Family & Domainsi

Domaini

Contains a short N-terminal coiled-coil domain and a C-terminal globular domain.1 Publication

Sequence similaritiesi

Belongs to the Rnk family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105NXH Bacteria
COG0782 LUCA
HOGENOMiHOG000208216
InParanoidiP0AFW4
KOiK06140
OMAiDVITMNS
PhylomeDBiP0AFW4

Family and domain databases

Gene3Di3.10.50.30, 1 hit
HAMAPiMF_00954 Rnk, 1 hit
InterProiView protein in InterPro
IPR036953 GreA/GreB_C_sf
IPR028625 Rnk
IPR029462 Rnk_N
IPR001437 Tscrpt_elong_fac_GreA/B_C
IPR023459 Tscrpt_elong_fac_GreA/B_fam
PANTHERiPTHR30437 PTHR30437, 1 hit
PfamiView protein in Pfam
PF01272 GreA_GreB, 1 hit
PF14760 Rnk_N, 1 hit
PIRSFiPIRSF006092 GreA_GreB, 1 hit

Sequencei

Sequence statusi: Complete.

P0AFW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPTIIIND LDAERIDILL EQPAYAGLPI ADALNAELDR AQMCSPEEMP
60 70 80 90 100
HDVVTMNSRV KFRNLSDGEV RVRTLVYPAK MTDSNTQLSV MAPVGAALLG
110 120 130
LRVGDSIHWE LPGGVATHLE VLELEYQPEA AGDYLL
Length:136
Mass (Da):14,927
Last modified:December 20, 2005 - v1
Checksum:i7043926623BA5E1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37900 Genomic DNA Translation: AAC36933.1
U82598 Genomic DNA Translation: AAB40810.1
U00096 Genomic DNA Translation: AAC73711.1
AP009048 Genomic DNA Translation: BAA35239.1
PIRiI57917
RefSeqiNP_415143.1, NC_000913.3
WP_000089731.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73711; AAC73711; b0610
BAA35239; BAA35239; BAA35239
GeneIDi947546
KEGGiecj:JW0602
eco:b0610
PATRICifig|1411691.4.peg.1658

Entry informationi

Entry nameiRNK_ECOLI
AccessioniPrimary (citable) accession number: P0AFW4
Secondary accession number(s): P40679
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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