ID   YHID_ECOLI              Reviewed;         215 AA.
AC   P0AFV2; P26606; Q2M7H0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   27-MAR-2024, entry version 117.
DE   RecName: Full=Putative magnesium transporter YhiD;
GN   Name=yhiD; Synonyms=yhhE; OrderedLocusNames=b3508, JW5670;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA   Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT   "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT   from 76.0 to 81.5 minutes.";
RL   Nucleic Acids Res. 22:2576-2586(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-148.
RC   STRAIN=K12;
RX   PubMed=8455549; DOI=10.1007/bf00282791;
RA   Yoshida T., Ueguchi C., Yamada H., Mizuno T.;
RT   "Function of the Escherichia coli nucleoid protein, H-NS: molecular
RT   analysis of a subset of proteins whose expression is enhanced in a hns
RT   deletion mutant.";
RL   Mol. Gen. Genet. 237:113-122(1993).
RN   [5]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19798051; DOI=10.1038/emboj.2009.288;
RA   Hattori M., Iwase N., Furuya N., Tanaka Y., Tsukazaki T., Ishitani R.,
RA   Maguire M.E., Ito K., Maturana A., Nureki O.;
RT   "Mg(2+)-dependent gating of bacterial MgtE channel underlies Mg(2+)
RT   homeostasis.";
RL   EMBO J. 28:3602-3612(2009).
CC   -!- FUNCTION: Could be involved in magnesium uptake.
CC       {ECO:0000269|PubMed:19798051}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of yhiD in addition to mgtA and corA
CC       leads to Mg(2+) auxotrophy. {ECO:0000269|PubMed:19798051}.
CC   -!- SIMILARITY: Belongs to the MgtC/SapB family. {ECO:0000305}.
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DR   EMBL; U00039; AAB18484.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC76533.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77786.1; -; Genomic_DNA.
DR   EMBL; D11109; BAA01885.1; -; Genomic_DNA.
DR   PIR; S47728; S47728.
DR   RefSeq; NP_417965.1; NC_000913.3.
DR   RefSeq; WP_001296814.1; NZ_STEB01000046.1.
DR   AlphaFoldDB; P0AFV2; -.
DR   SMR; P0AFV2; -.
DR   BioGRID; 4261142; 18.
DR   STRING; 511145.b3508; -.
DR   TCDB; 9.B.20.1.4; the putative mg(2+) transporter-c (mgtc) family.
DR   jPOST; P0AFV2; -.
DR   PaxDb; 511145-b3508; -.
DR   EnsemblBacteria; AAC76533; AAC76533; b3508.
DR   GeneID; 75203275; -.
DR   GeneID; 948019; -.
DR   KEGG; ecj:JW5670; -.
DR   KEGG; eco:b3508; -.
DR   PATRIC; fig|511145.12.peg.3615; -.
DR   EchoBASE; EB1372; -.
DR   eggNOG; COG1285; Bacteria.
DR   HOGENOM; CLU_079292_0_1_6; -.
DR   InParanoid; P0AFV2; -.
DR   OMA; IMITSQY; -.
DR   OrthoDB; 9811198at2; -.
DR   PhylomeDB; P0AFV2; -.
DR   BioCyc; EcoCyc:EG11400-MONOMER; -.
DR   PRO; PR:P0AFV2; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   InterPro; IPR003416; MgtC/SapB/SrpB/YhiD_fam.
DR   InterPro; IPR049177; MgtC_SapB_SrpB_YhiD_N.
DR   PANTHER; PTHR33778:SF1; MAGNESIUM TRANSPORTER YHID-RELATED; 1.
DR   PANTHER; PTHR33778; PROTEIN MGTC; 1.
DR   Pfam; PF02308; MgtC; 1.
DR   PRINTS; PR01837; MGTCSAPBPROT.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Magnesium; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..215
FT                   /note="Putative magnesium transporter YhiD"
FT                   /id="PRO_0000202032"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   215 AA;  23213 MW;  4F3E986281C3CF99 CRC64;
     MTAEFIIRLI LAAIACGAIG MERQMRGKGA GLRTHVLIGM GSALFMIVSK YGFADVLSLD
     HVGLDPSRIA AQVVTGVGFI GAGNILVRNQ NIVGLTTAAD IWVTAAIGMV IGSGMYELGI
     YGSVMTLLVL EVFHQLTFRL MNKNYHLQLT LVNGNTVSML DWFKQQKIKT DLVSLQENED
     HEVVAIDIQL HATTSIEDLL RLLKGMAGVK GVSIS
//