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Protein

Transcriptional regulatory protein BtsR

Gene

btsR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR, the low-affinity pyruvate signaling system YpdA/YpdB and their respective target proteins, BtsT and YhjX. Responds to depletion of nutrients, specifically serine, and the concomitant presence of extracellular pyruvate. BtsR regulates expression of btsT by binding to its promoter region. Activation of the BtsS/BtsR signaling cascade also suppresses YpdA/YpdB-mediated yhjX induction.4 Publications

GO - Molecular functioni

GO - Biological processi

  • phosphorelay signal transduction system Source: EcoCyc
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation, Two-component regulatory system

Enzyme and pathway databases

BioCyciEcoCyc:EG12006-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein BtsRCurated
Gene namesi
Name:btsR1 Publication
Synonyms:yehT
Ordered Locus Names:b2125, JW5352
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12006 yehT

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Deletion of btsSR has no obvious phenotypic effect under the conditions tested.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi54D → E: 2-fold increase in btsT induction. 1 Publication1
Mutagenesisi54D → N: 10-fold decrease in btsT induction. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000813611 – 239Transcriptional regulatory protein BtsRAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544-aspartylphosphatePROSITE-ProRule annotation1

Post-translational modificationi

Phosphorylated by BtsS.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0AFT5
PRIDEiP0AFT5

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4261849, 319 interactors
DIPiDIP-48085N
IntActiP0AFT5, 3 interactors
STRINGi316385.ECDH10B_2280

Structurei

3D structure databases

ProteinModelPortaliP0AFT5
SMRiP0AFT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 116Response regulatoryPROSITE-ProRule annotationAdd BLAST114
Domaini137 – 239HTH LytTR-typePROSITE-ProRule annotationAdd BLAST103

Phylogenomic databases

eggNOGiENOG4108NEV Bacteria
COG3279 LUCA
HOGENOMiHOG000242207
InParanoidiP0AFT5
KOiK02477
OMAiVVGECAN
PhylomeDBiP0AFT5

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR007492 LytTR_DNA-bd_dom
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF04397 LytTR, 1 hit
PF00072 Response_reg, 1 hit
SMARTiView protein in SMART
SM00850 LytTR, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS50930 HTH_LYTTR, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

P0AFT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKVLIVDDE PLARENLRVF LQEQSDIEIV GECSNAVEGI GAVHKLRPDV
60 70 80 90 100
LFLDIQMPRI SGLEMVGMLD PEHRPYIVFL TAFDEYAIKA FEEHAFDYLL
110 120 130 140 150
KPIDEARLEK TLARLRQERS KQDVSLLPEN QQALKFIPCT GHSRIYLLQM
160 170 180 190 200
KDVAFVSSRM SGVYVTSHEG KEGFTELTLR TLESRTPLLR CHRQYLVNLA
210 220 230
HLQEIRLEDN GQAELILRNG LTVPVSRRYL KSLKEAIGL
Length:239
Mass (Da):27,400
Last modified:December 20, 2005 - v1
Checksum:i5665AAE782B7FBA3
GO

Sequence cautioni

The sequence AAA60488 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA Translation: AAA60488.1 Different initiation.
U00096 Genomic DNA Translation: AAC75186.2
AP009048 Genomic DNA Translation: BAE76601.1
PIRiD64980
RefSeqiNP_416629.4, NC_000913.3
WP_000598641.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75186; AAC75186; b2125
BAE76601; BAE76601; BAE76601
GeneIDi949024
KEGGiecj:JW5352
eco:b2125
PATRICifig|1411691.4.peg.120

Similar proteinsi

Entry informationi

Entry nameiBTSR_ECOLI
AccessioniPrimary (citable) accession number: P0AFT5
Secondary accession number(s): P33356
, P76432, P76433, Q2MAV5, Q9ALR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

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