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Protein

Probable multidrug ABC transporter permease YbhS

Gene

ybhS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

  • efflux transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • drug transmembrane transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:YBHS-MONOMER.
MetaCyc:YBHS-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable multidrug ABC transporter permease YbhSCurated
Gene namesi
Name:ybhS
Ordered Locus Names:b0793, JW0777
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13675. ybhS.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicCuratedAdd BLAST28
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 181PeriplasmicCuratedAdd BLAST132
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 234CytoplasmicCuratedAdd BLAST32
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 261PeriplasmicCurated6
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 291CytoplasmicCurated9
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 345PeriplasmicCuratedAdd BLAST33
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Topological domaini367 – 377Cytoplasmic1 PublicationAdd BLAST11

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830051 – 377Probable multidrug ABC transporter permease YbhSAdd BLAST377

Proteomic databases

PaxDbiP0AFQ2.
PRIDEiP0AFQ2.

Expressioni

Inductioni

Repressed by the transcriptional regulator CecR.1 Publication

Interactioni

Subunit structurei

The complex is probably composed of two ATP-binding proteins (YbhF) and two transmembrane proteins (YbhR and YbhS).Curated

Protein-protein interaction databases

BioGridi4261835. 12 interactors.
IntActiP0AFQ2. 5 interactors.
STRINGi316385.ECDH10B_0861.

Structurei

3D structure databases

ProteinModelPortaliP0AFQ2.
SMRiP0AFQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 375ABC transmembrane type-2PROSITE-ProRule annotationAdd BLAST231

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QWP. Bacteria.
COG0842. LUCA.
HOGENOMiHOG000270977.
InParanoidiP0AFQ2.
KOiK01992.
OMAiGILMEQQ.
PhylomeDBiP0AFQ2.

Family and domain databases

InterProiView protein in InterPro
IPR000412. ABC_2_transport.
PROSITEiView protein in PROSITE
PS51012. ABC_TM2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AFQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPILSWRR VRALCVKETR QIVRDPSSWL IAVVIPLLLL FIFGYGINLD
60 70 80 90 100
SSKLRVGILL EQRSEAALDF THTMTGSPYI DATISDNRQE LIAKMQAGKI
110 120 130 140 150
RGLVVIPVDF AEQMERANAT APIQVITDGS EPNTANFVQG YVEGIWQIWQ
160 170 180 190 200
MQRAEDNGQT FEPLIDVQTR YWFNPAAISQ HFIIPGAVTI IMTVIGAILT
210 220 230 240 250
SLVVAREWER GTMEALLSTE ITRTELLLCK LIPYYFLGML AMLLCMLVSV
260 270 280 290 300
FILGVPYRGS LLILFFISSL FLLSTLGMGL LISTITRNQF NAAQVALNAA
310 320 330 340 350
FLPSIMLSGF IFQIDSMPAV IRAVTYIIPA RYFVSTLQSL FLAGNIPVVL
360 370
VVNVLFLIAS AVMFIGLTWL KTKRRLD
Length:377
Mass (Da):42,060
Last modified:December 20, 2005 - v1
Checksum:iC25E40FA4586EEFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73880.1.
AP009048 Genomic DNA. Translation: BAA35453.1.
PIRiA64816.
RefSeqiNP_415314.1. NC_000913.3.
WP_000070131.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73880; AAC73880; b0793.
BAA35453; BAA35453; BAA35453.
GeneIDi945411.
KEGGiecj:JW0777.
eco:b0793.
PATRICifig|1411691.4.peg.1485.

Similar proteinsi

Entry informationi

Entry nameiYBHS_ECOLI
AccessioniPrimary (citable) accession number: P0AFQ2
Secondary accession number(s): P75775
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome