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Protein

Probable multidrug ABC transporter permease YbhR

Gene

ybhR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the membrane.1 Publication

GO - Molecular functioni

  • efflux transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • drug transmembrane transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:YBHR-MONOMER.
MetaCyc:YBHR-MONOMER.

Protein family/group databases

TCDBi3.A.1.105.15. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable multidrug ABC transporter permease YbhRCurated
Gene namesi
Name:ybhR
Ordered Locus Names:b0792, JW5803
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13674. ybhR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicCuratedAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 173PeriplasmicCuratedAdd BLAST128
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 222CytoplasmicCuratedAdd BLAST28
Transmembranei223 – 243HelicalSequence analysisAdd BLAST21
Topological domaini244 – 253PeriplasmicCurated10
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 284CytoplasmicCurated10
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 339PeriplasmicCuratedAdd BLAST34
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 368Cytoplasmic1 Publication8

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830021 – 368Probable multidrug ABC transporter permease YbhRAdd BLAST368

Proteomic databases

PaxDbiP0AFP9.
PRIDEiP0AFP9.

Expressioni

Inductioni

Repressed by the transcriptional regulator CecR.1 Publication

Interactioni

Subunit structurei

The complex is probably composed of two ATP-binding proteins (YbhF) and two transmembrane proteins (YbhR and YbhS).Curated

Protein-protein interaction databases

BioGridi4261834. 20 interactors.
DIPiDIP-48088N.
IntActiP0AFP9. 1 interactor.
STRINGi316385.ECDH10B_0860.

Structurei

3D structure databases

ProteinModelPortaliP0AFP9.
SMRiP0AFP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 366ABC transmembrane type-2PROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QWP. Bacteria.
COG0842. LUCA.
HOGENOMiHOG000270979.
InParanoidiP0AFP9.
KOiK01992.
OMAiFDQLMVS.
PhylomeDBiP0AFP9.

Family and domain databases

InterProiView protein in InterPro
IPR000412. ABC_2_transport.
PRINTSiPR00164. ABC2TRNSPORT.
PROSITEiView protein in PROSITE
PS51012. ABC_TM2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AFP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHRLWTLIR KELQSLLREP QTRAILILPV LIQVILFPFA ATLEVTNATI
60 70 80 90 100
AIYDEDNGEH SVELTQRFAR ASAFTHVLLL KSPQEIRPTI DTQKALLLVR
110 120 130 140 150
FPADFSRKLD TFQTAPLQLI LDGRNSNSAQ IAANYLQQIV KNYQQELLEG
160 170 180 190 200
KPKPNNSELV VRNWYNPNLD YKWFVVPSLI AMITTIGVMI VTSLSVARER
210 220 230 240 250
EQGTLDQLLV SPLTTWQIFI GKAVPALIVA TFQATIVLAI GIWAYQIPFA
260 270 280 290 300
GSLALFYFTM VIYGLSLVGF GLLISSLCST QQQAFIGVFV FMMPAILLSG
310 320 330 340 350
YVSPVENMPV WLQNLTWINP IRHFTDITKQ IYLKDASLDI VWNSLWPLLV
360
ITATTGSAAY AMFRRKVM
Length:368
Mass (Da):41,566
Last modified:December 20, 2005 - v1
Checksum:iCD9380B094EB86F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73879.1.
AP009048 Genomic DNA. Translation: BAA35451.2.
PIRiH64815.
RefSeqiNP_415313.1. NC_000913.3.
WP_000469031.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73879; AAC73879; b0792.
BAA35451; BAA35451; BAA35451.
GeneIDi945403.
KEGGiecj:JW5803.
eco:b0792.
PATRICifig|1411691.4.peg.1486.

Similar proteinsi

Entry informationi

Entry nameiYBHR_ECOLI
AccessioniPrimary (citable) accession number: P0AFP9
Secondary accession number(s): P75774, Q9ZBC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome