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Protein

Inner membrane transport permease YadH

Gene

yadH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YADH-MONOMER.
ECOL316407:JW0124-MONOMER.

Protein family/group databases

TCDBi3.A.1.105.17. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane transport permease YadH
Gene namesi
Name:yadH
Ordered Locus Names:b0128, JW0124
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12321. yadH.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22PeriplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 52CytoplasmicSequence analysis9
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 94PeriplasmicSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116CytoplasmicSequence analysis1
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138PeriplasmicSequence analysis1
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 169CytoplasmicSequence analysis10
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 223PeriplasmicSequence analysisAdd BLAST33
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 256CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829981 – 256Inner membrane transport permease YadHAdd BLAST256

Proteomic databases

PaxDbiP0AFN6.
PRIDEiP0AFN6.

Interactioni

Protein-protein interaction databases

BioGridi4259734. 5 interactors.
STRINGi511145.b0128.

Structurei

3D structure databases

ProteinModelPortaliP0AFN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 251ABC transmembrane type-2PROSITE-ProRule annotationAdd BLAST230

Sequence similaritiesi

Contains 1 ABC transmembrane type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105E3A. Bacteria.
COG0842. LUCA.
HOGENOMiHOG000252768.
InParanoidiP0AFN6.
KOiK01992.
OMAiFQVHSWL.
PhylomeDBiP0AFN6.

Family and domain databases

InterProiIPR013525. ABC_2_trans.
IPR000412. ABC_2_transport.
[Graphical view]
PANTHERiPTHR30413. PTHR30413. 1 hit.
PfamiPF01061. ABC2_membrane. 1 hit.
[Graphical view]
PIRSFiPIRSF006648. DrrB. 1 hit.
PRINTSiPR00164. ABC2TRNSPORT.
PROSITEiPS51012. ABC_TM2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AFN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMHLYWVALK SIWAKEIHRF MRIWVQTLVP PVITMTLYFI IFGNLIGSRI
60 70 80 90 100
GDMHGFSYMQ FIVPGLIMMS VITNAYANVA SSFFGAKFQR NIEELLVAPV
110 120 130 140 150
PTHVIIAGYV GGGVARGLFV GILVTAISLF FVPFQVHSWV FVALTLVLTA
160 170 180 190 200
VLFSLAGLLN GVFAKTFDDI SLVPTFVLTP LTYLGGVFYS LTLLPPFWQG
210 220 230 240 250
LSHLNPIVYM ISGFRYGFLG INDVPLVTTF GVLVVFIVAF YLICWSLIQR

GRGLRS
Length:256
Mass (Da):28,516
Last modified:December 20, 2005 - v1
Checksum:i2AE10E6CB143F708
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti214F → L (PubMed:9278503).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73239.1.
AP009048 Genomic DNA. Translation: BAB96705.2.
PIRiH64735.
RefSeqiNP_414670.1. NC_000913.3.
WP_000972203.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73239; AAC73239; b0128.
BAB96705; BAB96705; BAB96705.
GeneIDi944836.
KEGGiecj:JW0124.
eco:b0128.
PATRICi32115359. VBIEscCol129921_0131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73239.1.
AP009048 Genomic DNA. Translation: BAB96705.2.
PIRiH64735.
RefSeqiNP_414670.1. NC_000913.3.
WP_000972203.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AFN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259734. 5 interactors.
STRINGi511145.b0128.

Protein family/group databases

TCDBi3.A.1.105.17. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AFN6.
PRIDEiP0AFN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73239; AAC73239; b0128.
BAB96705; BAB96705; BAB96705.
GeneIDi944836.
KEGGiecj:JW0124.
eco:b0128.
PATRICi32115359. VBIEscCol129921_0131.

Organism-specific databases

EchoBASEiEB2226.
EcoGeneiEG12321. yadH.

Phylogenomic databases

eggNOGiENOG4105E3A. Bacteria.
COG0842. LUCA.
HOGENOMiHOG000252768.
InParanoidiP0AFN6.
KOiK01992.
OMAiFQVHSWL.
PhylomeDBiP0AFN6.

Enzyme and pathway databases

BioCyciEcoCyc:YADH-MONOMER.
ECOL316407:JW0124-MONOMER.

Miscellaneous databases

PROiP0AFN6.

Family and domain databases

InterProiIPR013525. ABC_2_trans.
IPR000412. ABC_2_transport.
[Graphical view]
PANTHERiPTHR30413. PTHR30413. 1 hit.
PfamiPF01061. ABC2_membrane. 1 hit.
[Graphical view]
PIRSFiPIRSF006648. DrrB. 1 hit.
PRINTSiPR00164. ABC2TRNSPORT.
PROSITEiPS51012. ABC_TM2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYADH_ECOLI
AccessioniPrimary (citable) accession number: P0AFN6
Secondary accession number(s): P36880, P75657, Q8KMY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.