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P0AFL5

- PPIA_ECO57

UniProt

P0AFL5 - PPIA_ECO57

Protein

Peptidyl-prolyl cis-trans isomerase A

Gene

ppiA

Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Enzyme and pathway databases

    BioCyciECOL386585:GJFA-4184-MONOMER.
    ECOO157:PPIA-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase A (EC:5.2.1.8)
    Short name:
    PPIase A
    Alternative name(s):
    Cyclophilin A
    Rotamase A
    Gene namesi
    Name:ppiA
    Ordered Locus Names:Z4724, ECs4214
    OrganismiEscherichia coli O157:H7
    Taxonomic identifieri83334 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424By similarityAdd
    BLAST
    Chaini25 – 190166Peptidyl-prolyl cis-trans isomerase APRO_0000045120Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi155864.Z4724.

    Structurei

    3D structure databases

    ProteinModelPortaliP0AFL5.
    SMRiP0AFL5. Positions 25-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 188162PPIase cyclophilin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclophilin-type PPIase family.Curated
    Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0652.
    HOGENOMiHOG000065978.
    KOiK03767.
    OMAiTTPIVIQ.
    OrthoDBiEOG6S26C3.

    Family and domain databases

    Gene3Di2.40.100.10. 1 hit.
    InterProiIPR029000. Cyclophilin-like_dom.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view]
    PfamiPF00160. Pro_isomerase. 1 hit.
    [Graphical view]
    PRINTSiPR00153. CSAPPISMRASE.
    SUPFAMiSSF50891. SSF50891. 1 hit.
    PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0AFL5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKSTLAAMA AVFALSALSP AAMAAKGDPH VLLTTSAGNI ELELDKQKAP    50
    VSVQNFVDYV NSGFYNNTTF HRVIPGFMIQ GGGFTEQMQQ KKPNPPIKNE 100
    ADNGLRNTRG TIAMARTADK DSATSQFFIN VADNAFLDHG QRDFGYAVFG 150
    KVVKGMDVAD KISQVPTHDV GPYQNVPSKP VVILSAKVLP 190
    Length:190
    Mass (Da):20,431
    Last modified:December 20, 2005 - v1
    Checksum:i8B48535F36AA61A2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG58471.1.
    BA000007 Genomic DNA. Translation: BAB37637.1.
    PIRiC86001.
    F91155.
    RefSeqiNP_289911.1. NC_002655.2.
    NP_312241.1. NC_002695.1.

    Genome annotation databases

    EnsemblBacteriaiAAG58471; AAG58471; Z4724.
    BAB37637; BAB37637; BAB37637.
    GeneIDi915930.
    961533.
    KEGGiece:Z4724.
    ecs:ECs4214.
    PATRICi18357976. VBIEscCol44059_4155.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005174 Genomic DNA. Translation: AAG58471.1 .
    BA000007 Genomic DNA. Translation: BAB37637.1 .
    PIRi C86001.
    F91155.
    RefSeqi NP_289911.1. NC_002655.2.
    NP_312241.1. NC_002695.1.

    3D structure databases

    ProteinModelPortali P0AFL5.
    SMRi P0AFL5. Positions 25-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 155864.Z4724.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG58471 ; AAG58471 ; Z4724 .
    BAB37637 ; BAB37637 ; BAB37637 .
    GeneIDi 915930.
    961533.
    KEGGi ece:Z4724.
    ecs:ECs4214.
    PATRICi 18357976. VBIEscCol44059_4155.

    Phylogenomic databases

    eggNOGi COG0652.
    HOGENOMi HOG000065978.
    KOi K03767.
    OMAi TTPIVIQ.
    OrthoDBi EOG6S26C3.

    Enzyme and pathway databases

    BioCyci ECOL386585:GJFA-4184-MONOMER.
    ECOO157:PPIA-MONOMER.

    Family and domain databases

    Gene3Di 2.40.100.10. 1 hit.
    InterProi IPR029000. Cyclophilin-like_dom.
    IPR020892. Cyclophilin-type_PPIase_CS.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view ]
    Pfami PF00160. Pro_isomerase. 1 hit.
    [Graphical view ]
    PRINTSi PR00153. CSAPPISMRASE.
    SUPFAMi SSF50891. SSF50891. 1 hit.
    PROSITEi PS00170. CSA_PPIASE_1. 1 hit.
    PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
    2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
      Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
      , Kuhara S., Shiba T., Hattori M., Shinagawa H.
      DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

    Entry informationi

    Entry nameiPPIA_ECO57
    AccessioniPrimary (citable) accession number: P0AFL5
    Secondary accession number(s): P20752
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3