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P0AFL5

- PPIA_ECO57

UniProt

P0AFL5 - PPIA_ECO57

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Protein
Peptidyl-prolyl cis-trans isomerase A
Gene
ppiA, Z4724, ECs4214
Organism
Escherichia coli O157:H7
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciECOL386585:GJFA-4184-MONOMER.
ECOO157:PPIA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase A (EC:5.2.1.8)
Short name:
PPIase A
Alternative name(s):
Cyclophilin A
Rotamase A
Gene namesi
Name:ppiA
Ordered Locus Names:Z4724, ECs4214
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000558: Chromosome, UP000002519: Chromosome

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 By similarity
Add
BLAST
Chaini25 – 190166Peptidyl-prolyl cis-trans isomerase A
PRO_0000045120Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi155864.Z4724.

Structurei

3D structure databases

ProteinModelPortaliP0AFL5.
SMRiP0AFL5. Positions 25-190.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 188162PPIase cyclophilin-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0652.
HOGENOMiHOG000065978.
KOiK03767.
OMAiTTPIVIQ.
OrthoDBiEOG6S26C3.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AFL5-1 [UniParc]FASTAAdd to Basket

« Hide

MFKSTLAAMA AVFALSALSP AAMAAKGDPH VLLTTSAGNI ELELDKQKAP    50
VSVQNFVDYV NSGFYNNTTF HRVIPGFMIQ GGGFTEQMQQ KKPNPPIKNE 100
ADNGLRNTRG TIAMARTADK DSATSQFFIN VADNAFLDHG QRDFGYAVFG 150
KVVKGMDVAD KISQVPTHDV GPYQNVPSKP VVILSAKVLP 190
Length:190
Mass (Da):20,431
Last modified:December 20, 2005 - v1
Checksum:i8B48535F36AA61A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58471.1.
BA000007 Genomic DNA. Translation: BAB37637.1.
PIRiC86001.
F91155.
RefSeqiNP_289911.1. NC_002655.2.
NP_312241.1. NC_002695.1.

Genome annotation databases

EnsemblBacteriaiAAG58471; AAG58471; Z4724.
BAB37637; BAB37637; BAB37637.
GeneIDi915930.
961533.
KEGGiece:Z4724.
ecs:ECs4214.
PATRICi18357976. VBIEscCol44059_4155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005174 Genomic DNA. Translation: AAG58471.1 .
BA000007 Genomic DNA. Translation: BAB37637.1 .
PIRi C86001.
F91155.
RefSeqi NP_289911.1. NC_002655.2.
NP_312241.1. NC_002695.1.

3D structure databases

ProteinModelPortali P0AFL5.
SMRi P0AFL5. Positions 25-190.
ModBasei Search...

Protein-protein interaction databases

STRINGi 155864.Z4724.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG58471 ; AAG58471 ; Z4724 .
BAB37637 ; BAB37637 ; BAB37637 .
GeneIDi 915930.
961533.
KEGGi ece:Z4724.
ecs:ECs4214.
PATRICi 18357976. VBIEscCol44059_4155.

Phylogenomic databases

eggNOGi COG0652.
HOGENOMi HOG000065978.
KOi K03767.
OMAi TTPIVIQ.
OrthoDBi EOG6S26C3.

Enzyme and pathway databases

BioCyci ECOL386585:GJFA-4184-MONOMER.
ECOO157:PPIA-MONOMER.

Family and domain databases

Gene3Di 2.40.100.10. 1 hit.
InterProi IPR029000. Cyclophilin-like_dom.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view ]
Pfami PF00160. Pro_isomerase. 1 hit.
[Graphical view ]
PRINTSi PR00153. CSAPPISMRASE.
SUPFAMi SSF50891. SSF50891. 1 hit.
PROSITEi PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiPPIA_ECO57
AccessioniPrimary (citable) accession number: P0AFL5
Secondary accession number(s): P20752
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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