Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spermidine/putrescine transport system permease protein PotC

Gene

potC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine.

GO - Molecular functioni

  • spermidine-importing ATPase activity Source: EcoCyc

GO - Biological processi

  • putrescine transport Source: EcoCyc
  • spermidine transmembrane transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:POTC-MONOMER.
MetaCyc:POTC-MONOMER.

Protein family/group databases

TCDBi3.A.1.11.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Spermidine/putrescine transport system permease protein PotC
Gene namesi
Name:potC
Ordered Locus Names:b1124, JW1110
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10751. potC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 27HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini28 – 65PeriplasmicSequence analysisAdd BLAST38
Transmembranei66 – 85HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini86 – 100CytoplasmicSequence analysisAdd BLAST15
Transmembranei101 – 120HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini121 – 128PeriplasmicSequence analysis8
Transmembranei129 – 148HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini149 – 176CytoplasmicSequence analysisAdd BLAST28
Transmembranei177 – 196HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini197 – 231PeriplasmicSequence analysisAdd BLAST35
Transmembranei232 – 251HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini252 – 264CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000601811 – 264Spermidine/putrescine transport system permease protein PotCAdd BLAST264

Proteomic databases

PaxDbiP0AFK6.
PRIDEiP0AFK6.

Interactioni

Protein-protein interaction databases

BioGridi4260092. 8 interactors.
DIPiDIP-48152N.
IntActiP0AFK6. 1 interactor.
MINTiMINT-1315836.
STRINGi316385.ECDH10B_1196.

Structurei

3D structure databases

ProteinModelPortaliP0AFK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 248ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST189

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D38. Bacteria.
COG1177. LUCA.
HOGENOMiHOG000263700.
InParanoidiP0AFK6.
KOiK11070.
PhylomeDBiP0AFK6.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
InterProiView protein in InterPro
IPR000515. MetI-like.
PfamiView protein in Pfam
PF00528. BPD_transp_1. 1 hit.
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiView protein in PROSITE
PS50928. ABC_TM1. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AFK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGRLLRGGF MTAIYAYLYI PIIILIVNSF NSSRFGINWQ GFTTKWYSLL
60 70 80 90 100
MNNDSLLQAA QHSLTMAVFS ATFATLIGSL TAVALYRYRF RGKPFVSGML
110 120 130 140 150
FVVMMSPDIV MAISLLVLFM LLGIQLGFWS LLFSHITFCL PFVVVTVYSR
160 170 180 190 200
LKGFDVRMLE AAKDLGASEF TILRKIILPL AMPAVAAGWV LSFTLSMDDV
210 220 230 240 250
VVSSFVTGPS YEILPLKIYS MVKVGVSPEV NALATILLVL SLVMVIASQL
260
IARDKTKGNT GDVK
Length:264
Mass (Da):29,111
Last modified:December 20, 2005 - v1
Checksum:iD21619C91184BB59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64519 Genomic DNA. Translation: AAC37040.1.
U00096 Genomic DNA. Translation: AAC74208.1.
AP009048 Genomic DNA. Translation: BAA35944.1.
PIRiC40840.
RefSeqiNP_415642.1. NC_000913.3.
WP_000580316.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74208; AAC74208; b1124.
BAA35944; BAA35944; BAA35944.
GeneIDi945691.
KEGGiecj:JW1110.
eco:b1124.
PATRICifig|1411691.4.peg.1143.

Similar proteinsi

Entry informationi

Entry nameiPOTC_ECOLI
AccessioniPrimary (citable) accession number: P0AFK6
Secondary accession number(s): P23859
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: August 30, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families