Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spermidine/putrescine transport system permease protein PotC

Gene

potC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine.

GO - Molecular functioni

  • polyamine-transporting ATPase activity Source: EcoCyc

GO - Biological processi

  • polyamine transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:POTC-MONOMER.
ECOL316407:JW1110-MONOMER.
MetaCyc:POTC-MONOMER.
RETL1328306-WGS:GSTH-5712-MONOMER.

Protein family/group databases

TCDBi3.A.1.11.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Spermidine/putrescine transport system permease protein PotC
Gene namesi
Name:potC
Ordered Locus Names:b1124, JW1110
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10751. potC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence analysis
Transmembranei8 – 2720HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini28 – 6538PeriplasmicSequence analysisAdd
BLAST
Transmembranei66 – 8520HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini86 – 10015CytoplasmicSequence analysisAdd
BLAST
Transmembranei101 – 12020HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini121 – 1288PeriplasmicSequence analysis
Transmembranei129 – 14820HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini149 – 17628CytoplasmicSequence analysisAdd
BLAST
Transmembranei177 – 19620HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini197 – 23135PeriplasmicSequence analysisAdd
BLAST
Transmembranei232 – 25120HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini252 – 26413CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Spermidine/putrescine transport system permease protein PotCPRO_0000060181Add
BLAST

Proteomic databases

PaxDbiP0AFK6.

Interactioni

Protein-protein interaction databases

BioGridi4260092. 8 interactions.
DIPiDIP-48152N.
IntActiP0AFK6. 1 interaction.
MINTiMINT-1315836.
STRINGi511145.b1124.

Structurei

3D structure databases

ProteinModelPortaliP0AFK6.
SMRiP0AFK6. Positions 50-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 248189ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D38. Bacteria.
COG1177. LUCA.
HOGENOMiHOG000263700.
InParanoidiP0AFK6.
KOiK11070.
OMAiNWYSLLM.
PhylomeDBiP0AFK6.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AFK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGRLLRGGF MTAIYAYLYI PIIILIVNSF NSSRFGINWQ GFTTKWYSLL
60 70 80 90 100
MNNDSLLQAA QHSLTMAVFS ATFATLIGSL TAVALYRYRF RGKPFVSGML
110 120 130 140 150
FVVMMSPDIV MAISLLVLFM LLGIQLGFWS LLFSHITFCL PFVVVTVYSR
160 170 180 190 200
LKGFDVRMLE AAKDLGASEF TILRKIILPL AMPAVAAGWV LSFTLSMDDV
210 220 230 240 250
VVSSFVTGPS YEILPLKIYS MVKVGVSPEV NALATILLVL SLVMVIASQL
260
IARDKTKGNT GDVK
Length:264
Mass (Da):29,111
Last modified:December 20, 2005 - v1
Checksum:iD21619C91184BB59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64519 Genomic DNA. Translation: AAC37040.1.
U00096 Genomic DNA. Translation: AAC74208.1.
AP009048 Genomic DNA. Translation: BAA35944.1.
PIRiC40840.
RefSeqiNP_415642.1. NC_000913.3.
WP_000580316.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74208; AAC74208; b1124.
BAA35944; BAA35944; BAA35944.
GeneIDi945691.
KEGGiecj:JW1110.
eco:b1124.
PATRICi32117495. VBIEscCol129921_1170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64519 Genomic DNA. Translation: AAC37040.1.
U00096 Genomic DNA. Translation: AAC74208.1.
AP009048 Genomic DNA. Translation: BAA35944.1.
PIRiC40840.
RefSeqiNP_415642.1. NC_000913.3.
WP_000580316.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AFK6.
SMRiP0AFK6. Positions 50-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260092. 8 interactions.
DIPiDIP-48152N.
IntActiP0AFK6. 1 interaction.
MINTiMINT-1315836.
STRINGi511145.b1124.

Protein family/group databases

TCDBi3.A.1.11.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AFK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74208; AAC74208; b1124.
BAA35944; BAA35944; BAA35944.
GeneIDi945691.
KEGGiecj:JW1110.
eco:b1124.
PATRICi32117495. VBIEscCol129921_1170.

Organism-specific databases

EchoBASEiEB0744.
EcoGeneiEG10751. potC.

Phylogenomic databases

eggNOGiENOG4105D38. Bacteria.
COG1177. LUCA.
HOGENOMiHOG000263700.
InParanoidiP0AFK6.
KOiK11070.
OMAiNWYSLLM.
PhylomeDBiP0AFK6.

Enzyme and pathway databases

BioCyciEcoCyc:POTC-MONOMER.
ECOL316407:JW1110-MONOMER.
MetaCyc:POTC-MONOMER.
RETL1328306-WGS:GSTH-5712-MONOMER.

Miscellaneous databases

PROiP0AFK6.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOTC_ECOLI
AccessioniPrimary (citable) accession number: P0AFK6
Secondary accession number(s): P23859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.