Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nicotinamide riboside transporter PnuC

Gene

pnuC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for nicotinamide riboside transport across the inner membrane.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei188Nicotinamide ribosideBy similarity1
Binding sitei192Nicotinamide ribosideBy similarity1

GO - Molecular functioni

  • nicotinamide riboside transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • nicotinamide riboside transport Source: EcoCyc

Keywordsi

Biological processTransport
LigandNAD

Enzyme and pathway databases

BioCyciEcoCyc:PNUC-MONOMER
MetaCyc:PNUC-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinamide riboside transporter PnuC
Gene namesi
Name:pnuC
Ordered Locus Names:b0751, JW0734
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11700 pnuC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Topological domaini43 – 48PeriplasmicSequence analysis6
Transmembranei49 – 68HelicalSequence analysisAdd BLAST20
Topological domaini69 – 71CytoplasmicSequence analysis3
Transmembranei72 – 89HelicalSequence analysisAdd BLAST18
Topological domaini90 – 109PeriplasmicSequence analysisAdd BLAST20
Transmembranei110 – 127HelicalSequence analysisAdd BLAST18
Topological domaini128 – 157CytoplasmicSequence analysisAdd BLAST30
Transmembranei158 – 177HelicalSequence analysisAdd BLAST20
Topological domaini178 – 183PeriplasmicSequence analysis6
Transmembranei184 – 206HelicalSequence analysisAdd BLAST23
Topological domaini207 – 239Cytoplasmic1 PublicationAdd BLAST33

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584881 – 239Nicotinamide riboside transporter PnuCAdd BLAST239

Proteomic databases

PaxDbiP0AFK2
PRIDEiP0AFK2

Expressioni

Inductioni

Repressed by NadR.

Interactioni

Protein-protein interaction databases

BioGridi4259938, 8 interactors
STRINGi316385.ECDH10B_0818

Structurei

3D structure databases

ProteinModelPortaliP0AFK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4106Z1T Bacteria
COG3201 LUCA
HOGENOMiHOG000144393
InParanoidiP0AFK2
KOiK03811
OMAiVWLTVKQ
PhylomeDBiP0AFK2

Family and domain databases

InterProiView protein in InterPro
IPR006419 NMN_transpt_PnuC
PANTHERiPTHR36122 PTHR36122, 1 hit
PfamiView protein in Pfam
PF04973 NMN_transporter, 1 hit
TIGRFAMsiTIGR01528 NMN_trans_PnuC, 1 hit

Sequencei

Sequence statusi: Complete.

P0AFK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFFSVQNIL VHIPIGAGGY DLSWIEAVGT IAGLLCIGLA SLEKISNYFF
60 70 80 90 100
GLINVTLFGI IFFQIQLYAS LLLQVFFFAA NIYGWYAWSR QTSQNEAELK
110 120 130 140 150
IRWLPLPKAL SWLAVCVVSI GLMTVFINPV FAFLTRVAVM IMQALGLQVV
160 170 180 190 200
MPELQPDAFP FWDSCMMVLS IVAMILMTRK YVENWLLWVI INVISVVIFA
210 220 230
LQGVYAMSLE YIILTFIALN GSRMWINSAR ERGSRALSH
Length:239
Mass (Da):26,996
Last modified:December 20, 2005 - v1
Checksum:i5A01FC261A16CF61
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6 – 7VQ → TH (PubMed:2841129).Curated2
Sequence conflicti11V → I (PubMed:2841129).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73838.1
AP009048 Genomic DNA Translation: BAA35413.1
X12713 Genomic DNA No translation available.
PIRiG64810
RefSeqiNP_415272.1, NC_000913.3
WP_000345410.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73838; AAC73838; b0751
BAA35413; BAA35413; BAA35413
GeneIDi945350
KEGGiecj:JW0734
eco:b0751
PATRICifig|1411691.4.peg.1528

Similar proteinsi

Entry informationi

Entry nameiPNUC_ECOLI
AccessioniPrimary (citable) accession number: P0AFK2
Secondary accession number(s): P31215, P77227
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health