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Protein

Metalloprotease PmbA

Gene

pmbA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).1 Publication

Miscellaneous

In strains containing the pMccB17 plasmid, required for the maturation and secretion of the antibiotic bacteriocin microcin B17 (MccB17).1 Publication

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: EcoCyc

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease

Enzyme and pathway databases

BioCyciEcoCyc:EG10741-MONOMER.

Protein family/group databases

MEROPSiU62.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloprotease PmbA (EC:3.4.-.-)
Alternative name(s):
Protein TldE
Gene namesi
Name:pmbA
Synonyms:tldE
Ordered Locus Names:b4235, JW4194
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10741. pmbA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoCyc
  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001423511 – 450Metalloprotease PmbAAdd BLAST450

Proteomic databases

PaxDbiP0AFK0.
PRIDEiP0AFK0.

Interactioni

Protein-protein interaction databases

BioGridi4262248. 11 interactors.
DIPiDIP-47844N.
IntActiP0AFK0. 6 interactors.
STRINGi316385.ECDH10B_4430.

Structurei

3D structure databases

ProteinModelPortaliP0AFK0.
SMRiP0AFK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase U62 family.Curated

Phylogenomic databases

eggNOGiENOG4105CMS. Bacteria.
COG0312. LUCA.
HOGENOMiHOG000224928.
InParanoidiP0AFK0.
KOiK03592.
PhylomeDBiP0AFK0.

Family and domain databases

Gene3Di3.30.2290.10. 1 hit.
InterProiView protein in InterPro
IPR002510. TldD/PmbA.
IPR035068. TldD/PmbA_N.
PfamiView protein in Pfam
PF01523. PmbA_TldD. 1 hit.
SUPFAMiSSF111283. SSF111283. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AFK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAMKVISQ VEAQRKILEE AVSTALELAS GKSDGAEVAV SKTTGISVST
60 70 80 90 100
RYGEVENVEF NSDGALGITV YHQNRKGSAS STDLSPQAIA RTVQAALDIA
110 120 130 140 150
RYTSPDPCAG VADKELLAFD APDLDLFHPA EVSPDEAIEL AARAEQAALQ
160 170 180 190 200
ADKRITNTEG GSFNSHYGVK VFGNSHGMLQ GYCSTRHSLS SCVIAEENGD
210 220 230 240 250
MERDYAYTIG RAMSDLQTPE WVGADCARRT LSRLSPRKLS TMKAPVIFAN
260 270 280 290 300
EVATGLFGHL VGAIAGGSVY RKSTFLLDSL GKQILPDWLT IEEHPHLLKG
310 320 330 340 350
LASTPFDSEG VRTERRDIIK DGILTQWLLT SYSARKLGLK STGHAGGIHN
360 370 380 390 400
WRIAGQGLSF EQMLKEMGTG LVVTELMGQG VSAITGDYSR GAAGFWVENG
410 420 430 440 450
EIQYPVSEIT IAGNLKDMWR NIVTVGNDIE TRSNIQCGSV LLPEMKIAGQ
Length:450
Mass (Da):48,370
Last modified:December 20, 2005 - v1
Checksum:iA062969197B52B5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54152 Genomic DNA. Translation: CAA38091.1.
D44452 Genomic DNA. Translation: BAA07915.1.
U14003 Genomic DNA. Translation: AAA97132.1.
U00096 Genomic DNA. Translation: AAC77192.1.
AP009048 Genomic DNA. Translation: BAE78235.1.
PIRiS13730.
RefSeqiNP_418656.1. NC_000913.3.
WP_001162171.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77192; AAC77192; b4235.
BAE78235; BAE78235; BAE78235.
GeneIDi948750.
KEGGiecj:JW4194.
eco:b4235.
PATRICifig|1411691.4.peg.2467.

Similar proteinsi

Entry informationi

Entry nameiPMBA_ECOLI
AccessioniPrimary (citable) accession number: P0AFK0
Secondary accession number(s): P24231, Q2M671
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: August 30, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families