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Protein

Low-affinity inorganic phosphate transporter 1

Gene

pitA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Low-affinity inorganic phosphate transport. Can also transport arsenate.

GO - Molecular functioni

  • inorganic phosphate transmembrane transporter activity Source: EcoCyc
  • solute:proton symporter activity Source: EcoCyc
  • tellurite uptake transmembrane transporter activity Source: EcoCyc
  • zinc ion transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • phosphate ion transmembrane transport Source: EcoCyc
  • tellurite transport Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Phosphate transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:PITA-MONOMER.
ECOL316407:JW3460-MONOMER.
MetaCyc:PITA-MONOMER.

Protein family/group databases

TCDBi2.A.20.1.1. the inorganic phosphate transporter (pit) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Low-affinity inorganic phosphate transporter 1
Gene namesi
Name:pitA
Synonyms:pit
Ordered Locus Names:b3493, JW3460
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12230. pitA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44PeriplasmicSequence analysis
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Topological domaini26 – 5126CytoplasmicSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Topological domaini73 – 9321PeriplasmicSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 1239CytoplasmicSequence analysis
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Topological domaini145 – 15410PeriplasmicSequence analysis
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Topological domaini176 – 20631CytoplasmicSequence analysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence analysisAdd
BLAST
Topological domaini228 – 2325PeriplasmicSequence analysis
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Topological domaini254 – 381128CytoplasmicSequence analysisAdd
BLAST
Transmembranei382 – 40221HelicalSequence analysisAdd
BLAST
Topological domaini403 – 42927PeriplasmicSequence analysisAdd
BLAST
Transmembranei430 – 45021HelicalSequence analysisAdd
BLAST
Topological domaini451 – 47222CytoplasmicSequence analysisAdd
BLAST
Transmembranei473 – 49321HelicalSequence analysisAdd
BLAST
Topological domaini494 – 4996PeriplasmicSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Low-affinity inorganic phosphate transporter 1PRO_0000080782Add
BLAST

Proteomic databases

PaxDbiP0AFJ7.

Interactioni

Protein-protein interaction databases

STRINGi511145.b3493.

Structurei

3D structure databases

ProteinModelPortaliP0AFJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CJ3. Bacteria.
COG0306. LUCA.
HOGENOMiHOG000231893.
InParanoidiP0AFJ7.
KOiK16322.
OMAiYDITRTR.
PhylomeDBiP0AFJ7.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AFJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHLFAGLDL HTGLLLLLAL AFVLFYEAIN GFHDTANAVA TVIYTRAMRS
60 70 80 90 100
QLAVVMAAVF NFLGVLLGGL SVAYAIVHML PTDLLLNMGS SHGLAMVFSM
110 120 130 140 150
LLAAIIWNLG TWYFGLPASS SHTLIGAIIG IGLTNALMTG TSVVDALNIP
160 170 180 190 200
KVLSIFGSLI VSPIVGLVFA GGLIFLLRRY WSGTKKRARI HLTPAEREKK
210 220 230 240 250
DGKKKPPFWT RIALILSAIG VAFSHGANDG QKGIGLVMLV LIGVAPAGFV
260 270 280 290 300
VNMNATGYEI TRTRDAINNV EAYFEQHPAL LKQATGADQL VPAPEAGATQ
310 320 330 340 350
PAEFHCHPSN TINALNRLKG MLTTDVESYD KLSLDQRSQM RRIMLCVSDT
360 370 380 390 400
IDKVVKMPGV SADDQRLLKK LKSDMLSTIE YAPVWIIMAV ALALGIGTMI
410 420 430 440 450
GWRRVATTIG EKIGKKGMTY AQGMSAQMTA AVSIGLASYT GMPVSTTHVL
460 470 480 490
SSSVAGTMVV DGGGLQRKTV TSILMAWVFT LPAAVLLSGG LYWLSLQFL
Length:499
Mass (Da):53,389
Last modified:December 20, 2005 - v1
Checksum:i93D551131C524084
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18469.1.
U00096 Genomic DNA. Translation: AAC76518.1.
AP009048 Genomic DNA. Translation: BAE77801.1.
PIRiS47713.
RefSeqiNP_417950.1. NC_000913.3.
WP_000902780.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76518; AAC76518; b3493.
BAE77801; BAE77801; BAE77801.
GeneIDi948009.
KEGGiecj:JW3460.
eco:b3493.
PATRICi32122434. VBIEscCol129921_3594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA. Translation: AAB18469.1.
U00096 Genomic DNA. Translation: AAC76518.1.
AP009048 Genomic DNA. Translation: BAE77801.1.
PIRiS47713.
RefSeqiNP_417950.1. NC_000913.3.
WP_000902780.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AFJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b3493.

Protein family/group databases

TCDBi2.A.20.1.1. the inorganic phosphate transporter (pit) family.

Proteomic databases

PaxDbiP0AFJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76518; AAC76518; b3493.
BAE77801; BAE77801; BAE77801.
GeneIDi948009.
KEGGiecj:JW3460.
eco:b3493.
PATRICi32122434. VBIEscCol129921_3594.

Organism-specific databases

EchoBASEiEB2142.
EcoGeneiEG12230. pitA.

Phylogenomic databases

eggNOGiENOG4105CJ3. Bacteria.
COG0306. LUCA.
HOGENOMiHOG000231893.
InParanoidiP0AFJ7.
KOiK16322.
OMAiYDITRTR.
PhylomeDBiP0AFJ7.

Enzyme and pathway databases

BioCyciEcoCyc:PITA-MONOMER.
ECOL316407:JW3460-MONOMER.
MetaCyc:PITA-MONOMER.

Miscellaneous databases

PROiP0AFJ7.

Family and domain databases

InterProiIPR001204. Phos_transporter.
[Graphical view]
PANTHERiPTHR11101. PTHR11101. 1 hit.
PfamiPF01384. PHO4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPITA_ECOLI
AccessioniPrimary (citable) accession number: P0AFJ7
Secondary accession number(s): P37308, Q2M7F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.