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Protein

Putative permease PerM

Gene

perM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7310-MONOMER.
ECOL316407:JW2478-MONOMER.

Protein family/group databases

TCDBi2.A.86.1.1. the autoinducer-2 exporter (ai-2e) family (formerly the perm family, tc #9.b.22).

Names & Taxonomyi

Protein namesi
Recommended name:
Putative permease PerM
Gene namesi
Name:perM
Synonyms:yfgO
Ordered Locus Names:b2493, JW2478
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14221. perM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence analysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Putative permease PerMPRO_0000148294Add
BLAST

Proteomic databases

PaxDbiP0AFI9.
PRIDEiP0AFI9.

Interactioni

Protein-protein interaction databases

BioGridi4261433. 14 interactions.
IntActiP0AFI9. 1 interaction.
STRINGi511145.b2493.

Structurei

3D structure databases

ProteinModelPortaliP0AFI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0118 (PerM) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C02. Bacteria.
COG0628. LUCA.
HOGENOMiHOG000275836.
InParanoidiP0AFI9.
KOiK03548.
OMAiMPVAWQQ.
OrthoDBiEOG676Z20.
PhylomeDBiP0AFI9.

Family and domain databases

InterProiIPR002549. AI-2E-like.
[Graphical view]
PANTHERiPTHR21716. PTHR21716. 1 hit.
PfamiPF01594. UPF0118. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AFI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEMLMQWYR RRFSDPEAIA LLVILVAGFG IIFFFSGLLA PLLVAIVLAY
60 70 80 90 100
LLEWPTVRLQ SIGCSRRWAT SIVLVVFVGI LLLMAFVVLP IAWQQGIYLI
110 120 130 140 150
RDMPGMLNKL SDFAATLPRR YPALMDAGII DAMAENMRSR MLTMGDSVVK
160 170 180 190 200
ISLASLVGLL TIAVYLVLVP LMVFFLLKDK EQMLNAVRRV LPRNRGLAGQ
210 220 230 240 250
VWKEMNQQIT NYIRGKVLEM IVVGIATWLG FLLFGLNYSL LLAVLVGFSV
260 270 280 290 300
LIPYIGAFVV TIPVVGVALF QFGAGTEFWS CFAVYLIIQA LDGNLLVPVL
310 320 330 340 350
FSEAVNLHPL VIILSVVIFG GLWGFWGVFF AIPLATLIKA VIHAWPDGQI

AQE
Length:353
Mass (Da):39,194
Last modified:December 20, 2005 - v1
Checksum:iE1CB8EB1E242FC3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75546.1.
AP009048 Genomic DNA. Translation: BAA16382.1.
M63654 Genomic DNA. Translation: AAB88575.1. Sequence problems.
PIRiD65025.
RefSeqiNP_416988.1. NC_000913.3.
WP_000892044.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75546; AAC75546; b2493.
BAA16382; BAA16382; BAA16382.
GeneIDi945894.
KEGGiecj:JW2478.
eco:b2493.
PATRICi32120373. VBIEscCol129921_2589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75546.1.
AP009048 Genomic DNA. Translation: BAA16382.1.
M63654 Genomic DNA. Translation: AAB88575.1. Sequence problems.
PIRiD65025.
RefSeqiNP_416988.1. NC_000913.3.
WP_000892044.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AFI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261433. 14 interactions.
IntActiP0AFI9. 1 interaction.
STRINGi511145.b2493.

Protein family/group databases

TCDBi2.A.86.1.1. the autoinducer-2 exporter (ai-2e) family (formerly the perm family, tc #9.b.22).

Proteomic databases

PaxDbiP0AFI9.
PRIDEiP0AFI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75546; AAC75546; b2493.
BAA16382; BAA16382; BAA16382.
GeneIDi945894.
KEGGiecj:JW2478.
eco:b2493.
PATRICi32120373. VBIEscCol129921_2589.

Organism-specific databases

EchoBASEiEB3973.
EcoGeneiEG14221. perM.

Phylogenomic databases

eggNOGiENOG4105C02. Bacteria.
COG0628. LUCA.
HOGENOMiHOG000275836.
InParanoidiP0AFI9.
KOiK03548.
OMAiMPVAWQQ.
OrthoDBiEOG676Z20.
PhylomeDBiP0AFI9.

Enzyme and pathway databases

BioCyciEcoCyc:G7310-MONOMER.
ECOL316407:JW2478-MONOMER.

Miscellaneous databases

PROiP0AFI9.

Family and domain databases

InterProiIPR002549. AI-2E-like.
[Graphical view]
PANTHERiPTHR21716. PTHR21716. 1 hit.
PfamiPF01594. UPF0118. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
    Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T.
    , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
    DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Andrews S.C., McClay J., Ambler A., Quail M., Berks B.C., Guest J.R.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 279-353.
    Strain: K12.

Entry informationi

Entry nameiPERM_ECOLI
AccessioniPrimary (citable) accession number: P0AFI9
Secondary accession number(s): P71230, P77406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 20, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.