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P0AFI0 (OXC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable oxalyl-CoA decarboxylase
EC=4.1.1.8
Gene names
Name:oxc
Synonyms:yfdU
Ordered Locus Names:b2373, JW2370
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Oxalyl-CoA = formyl-CoA + CO2.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 2/2.

Sequence similarities

Belongs to the TPP enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 564564Probable oxalyl-CoA decarboxylase
PRO_0000090824

Secondary structure

1 ....................................................................................................... 564
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0AFI0 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 94418B2BE7D40C17

FASTA56460,581
        10         20         30         40         50         60 
MSDQLQMTDG MHIIVEALKQ NNIDTIYGVV GIPVTDMARH AQAEGIRYIG FRHEQSAGYA 

        70         80         90        100        110        120 
AAASGFLTQK PGICLTVSAP GFLNGLTALA NATVNGFPMI MISGSSDRAI VDLQQGDYEE 

       130        140        150        160        170        180 
LDQMNAAKPY AKAAFRVNQP QDLGIALARA IRVSVSGRPG GVYLDLPANV LAATMEKDEA 

       190        200        210        220        230        240 
LTTIVKVENP SPALLPCPKS VTSAISLLAK AERPLIILGK GAAYSQADEQ LREFIESAQI 

       250        260        270        280        290        300 
PFLPMSMAKG ILEDTHPLSA AAARSFALAN ADVVMLVGAR LNWLLAHGKK GWAADTQFIQ 

       310        320        330        340        350        360 
LDIEPQEIDS NRPIAVPVVG DIASSMQGML AELKQNTFTT PLVWRDILNI HKQQNAQKMH 

       370        380        390        400        410        420 
EKLSTDTQPL NYFNALSAVR DVLRENQDIY LVNEGANTLD NARNIIDMYK PRRRLDCGTW 

       430        440        450        460        470        480 
GVMGIGMGYA IGASVTSGSP VVAIEGDSAF GFSGMEIETI CRYNLPVTIV IFNNGGIYRG 

       490        500        510        520        530        540 
DGVDLSGAGA PSPTDLLHHA RYDKLMDAFR GVGYNVTTTD ELRHALTTGI QSRKPTIINV 

       550        560 
VIDPAAGTES GHITKLNPKQ VAGN

« Hide

References

[1]"Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features."
Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T., Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K., Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T. expand/collapse author list , Oyama S., Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H., Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.
DNA Res. 4:91-113(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U00096 Genomic DNA. Translation: AAC75432.1.
AP009048 Genomic DNA. Translation: BAA16245.1.
PIRB65011.
RefSeqNP_416874.1. NC_000913.2.
YP_490615.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q27X-ray2.12A/B1-564[»]
2Q28X-ray1.74A/B1-564[»]
2Q29X-ray1.82A/B1-564[»]
ProteinModelPortalP0AFI0.
SMRP0AFI0. Positions 5-554.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-48075N.
IntActP0AFI0. 6 interactions.
STRING511145.b2373.

Proteomic databases

PaxDbP0AFI0.
PRIDEP0AFI0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75432; AAC75432; b2373.
BAA16245; BAA16245; BAA16245.
GeneID12931868.
946845.
KEGGecj:Y75_p2340.
eco:b2373.
PATRIC32120125. VBIEscCol129921_2471.

Organism-specific databases

EchoBASEEB3895.
EcoGeneEG14143. oxc.

Phylogenomic databases

eggNOGCOG0028.
HOGENOMHOG000053808.
KOK01577.
OMAYARAENE.
ProtClustDBPRK09259.

Enzyme and pathway databases

BioCycEcoCyc:G7236-MONOMER.
ECOL316407:JW2370-MONOMER.
MetaCyc:G7236-MONOMER.
UniPathwayUPA00540; UER00599.

Gene expression databases

GenevestigatorP0AFI0.

Family and domain databases

InterProIPR017660. Oxalyl-CoA_decarboxylase.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR03254. oxalate_oxc. 1 hit.
PROSITEPS00187. TPP_ENZYMES. False negative.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0AFI0.

Entry information

Entry nameOXC_ECOLI
AccessionPrimary (citable) accession number: P0AFI0
Secondary accession number(s): P78093, P78194, P78195
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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