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Protein

Transcription termination/antitermination protein NusG

Gene

nusG

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination.UniRule annotation

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription antitermination, Transcription regulation, Transcription termination

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination/antitermination protein NusGUniRule annotation
Gene namesi
Name:nusGUniRule annotation
Ordered Locus Names:Z5555, ECs4905
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001139272 – 181Transcription termination/antitermination protein NusGAdd BLAST180

Proteomic databases

PRIDEiP0AFG1.

Interactioni

Subunit structurei

Monomer. Interacts with the transcription termination factor Rho and with RNA polymerase.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z5555.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5TBZX-ray7.00J/K1-181[»]
ProteinModelPortaliP0AFG1.
SMRiP0AFG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 161KOWUniRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the NusG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E5V. Bacteria.
COG0250. LUCA.
HOGENOMiHOG000219264.
KOiK02601.
OMAiDGPFNGF.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
3.30.70.940. 1 hit.
HAMAPiMF_00948. NusG. 1 hit.
InterProiView protein in InterPro
IPR005824. KOW.
IPR006645. NGN_dom.
IPR036735. NGN_dom_sf.
IPR014722. Rib_L2_dom2.
IPR001062. Transcrpt_antiterm_NusG.
IPR015869. Transcrpt_antiterm_NusG_bac_CS.
IPR008991. Translation_prot_SH3-like_sf.
PANTHERiPTHR30265:SF2. PTHR30265:SF2. 1 hit.
PfamiView protein in Pfam
PF00467. KOW. 1 hit.
PF02357. NusG. 1 hit.
PRINTSiPR00338. NUSGTNSCPFCT.
SMARTiView protein in SMART
SM00739. KOW. 1 hit.
SM00738. NGN. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF82679. SSF82679. 1 hit.
TIGRFAMsiTIGR00922. nusG. 1 hit.
PROSITEiView protein in PROSITE
PS01014. NUSG. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AFG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAPKKRWY VVQAFSGFEG RVATSLREHI KLHNMEDLFG EVMVPTEEVV
60 70 80 90 100
EIRGGQRRKS ERKFFPGYVL VQMVMNDASW HLVRSVPRVM GFIGGTSDRP
110 120 130 140 150
APISDKEVDA IMNRLQQVGD KPRPKTLFEP GEMVRVNDGP FADFNGVVEE
160 170 180
VDYEKSRLKV SVSIFGRATP VELDFSQVEK A
Length:181
Mass (Da):20,532
Last modified:January 23, 2007 - v2
Checksum:iB3AF94284CC17B04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG59178.1.
BA000007 Genomic DNA. Translation: BAB38328.1.
PIRiA98242.
F86089.
RefSeqiNP_312932.1. NC_002695.1.
WP_001287516.1. NZ_NOKN01000002.1.

Genome annotation databases

EnsemblBacteriaiAAG59178; AAG59178; Z5555.
BAB38328; BAB38328; BAB38328.
GeneIDi914947.
KEGGiece:Z5555.
ecs:ECs4905.
PATRICifig|386585.9.peg.5129.

Similar proteinsi

Entry informationi

Entry nameiNUSG_ECO57
AccessioniPrimary (citable) accession number: P0AFG1
Secondary accession number(s): P16921
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome