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Protein

Lipopolysaccharide export system permease protein LptF

Gene

lptF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.1 Publication

GO - Molecular functioni

  • lipopolysaccharide-transporting ATPase activity Source: EcoCyc

GO - Biological processi

  • lipopolysaccharide transport Source: EcoCyc

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:G7888-MONOMER
MetaCyc:G7888-MONOMER

Protein family/group databases

TCDBi1.B.42.1.2 the outer membrane lipopolysaccharide export porin (lps-ep) family

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide export system permease protein LptF
Gene namesi
Name:lptF
Synonyms:yjgP
Ordered Locus Names:b4261, JW4218
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12535 lptF

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 53PeriplasmicSequence analysisAdd BLAST17
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 100CytoplasmicSequence analysisAdd BLAST26
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 269PeriplasmicSequence analysisAdd BLAST148
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 295CytoplasmicSequence analysis5
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 327PeriplasmicSequence analysisAdd BLAST11
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 366CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of membrane Source: EcoCyc
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001697711 – 366Lipopolysaccharide export system permease protein LptFAdd BLAST366

Proteomic databases

PaxDbiP0AF98
PRIDEiP0AF98

Interactioni

Subunit structurei

Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).1 Publication

Protein-protein interaction databases

BioGridi4262727, 260 interactors
IntActiP0AF98, 1 interactor
MINTiP0AF98
STRINGi316385.ECDH10B_4454

Structurei

3D structure databases

ProteinModelPortaliP0AF98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LptF/LptG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108M8S Bacteria
COG0795 LUCA
HOGENOMiHOG000283246
InParanoidiP0AF98
KOiK07091
OMAiSEMVIWF
PhylomeDBiP0AF98

Family and domain databases

InterProiView protein in InterPro
IPR030922 LptF
IPR005495 LptG/LptF_permease
PANTHERiPTHR33529 PTHR33529, 1 hit
PfamiView protein in Pfam
PF03739 YjgP_YjgQ, 1 hit
TIGRFAMsiTIGR04407 LptF_YjgP, 1 hit

Sequencei

Sequence statusi: Complete.

P0AF98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIIRYLVRE TLKSQLAILF ILLLIFFCQK LVRILGAAVD GDIPANLVLS
60 70 80 90 100
LLGLGVPEMA QLILPLSLFL GLLMTLGKLY TESEITVMHA CGLSKAVLVK
110 120 130 140 150
AAMILAVFTA IVAAVNVMWA GPWSSRHQDE VLAEAKANPG MAALAQGQFQ
160 170 180 190 200
QATNGSSVLF IESVDGSDFK DVFLAQIRPK GNARPSVVVA DSGHLTQLRD
210 220 230 240 250
GSQVVTLNQG TRFEGTALLR DFRITDFQDY QAIIGHQAVA LDPNDTDQMD
260 270 280 290 300
MRTLWNTDTD RARAELNWRI TLVFTVFMMA LMVVPLSVVN PRQGRVLSML
310 320 330 340 350
PAMLLYLLFF LIQTSLKSNG GKGKLDPTLW MWTVNLIYLA LAIVLNLWDT
360
VPVRRLRASF SRKGAV
Length:366
Mass (Da):40,358
Last modified:December 20, 2005 - v1
Checksum:i69A564AA22CBFFEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97158.1
U00096 Genomic DNA Translation: AAC77218.1
AP009048 Genomic DNA Translation: BAE78258.1
PIRiS56487
RefSeqiNP_418682.1, NC_000913.3
WP_000584114.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77218; AAC77218; b4261
BAE78258; BAE78258; BAE78258
GeneIDi948795
KEGGiecj:JW4218
eco:b4261
PATRICifig|511145.12.peg.4392

Similar proteinsi

Entry informationi

Entry nameiLPTF_ECOLI
AccessioniPrimary (citable) accession number: P0AF98
Secondary accession number(s): P39340, Q2M648
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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