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Protein

Toxin-antitoxin biofilm protein TabA

Gene

tabA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Influences biofilm formation. Represses fimbria genes in 8 hours biofilms. May act in response to the combined activity of several toxin-antitoxin (TA) systems.1 Publication

GO - Biological processi

  • single-species biofilm formation Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7883-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin-antitoxin biofilm protein TabA
Gene namesi
Name:tabA
Synonyms:yjgK
Ordered Locus Names:b4252, JW5756
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12530 tabA

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

Pathology & Biotechi

Disruption phenotypei

Deletion increases biofilm formation after 8 hours and decreases biofilm formation after 24 hours.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001697651 – 150Toxin-antitoxin biofilm protein TabAAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36N6-acetyllysine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP0AF96
PRIDEiP0AF96

PTM databases

iPTMnetiP0AF96

Expressioni

Inductioni

Induced by simultaneous deletion of five TA systems (MazF/MazE, RelE/RelB, ChpB, YoeB/YefM, and YafQ/DinJ).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259562, 211 interactors
DIPiDIP-48214N
STRINGi316385.ECDH10B_4445

Structurei

3D structure databases

ProteinModelPortaliP0AF96
SMRiP0AF96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TabA/YhcH/YiaL family.Curated

Phylogenomic databases

eggNOGiENOG4105XEP Bacteria
COG2731 LUCA
HOGENOMiHOG000282947
InParanoidiP0AF96
KOiK19334
OMAiCLIKVLM
PhylomeDBiP0AF96

Family and domain databases

Gene3Di2.60.120.370, 1 hit
InterProiView protein in InterPro
IPR004375 YhcH/YjgK/YiaL
IPR037012 YhcH/YjgK/YiaL_sf
PANTHERiPTHR34986 PTHR34986, 1 hit
PfamiView protein in Pfam
PF04074 DUF386, 1 hit
TIGRFAMsiTIGR00022 TIGR00022, 1 hit

Sequencei

Sequence statusi: Complete.

P0AF96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIGNIHNLQ PWLPQELRQA IEHIKAHVTA ETPKGKHDIE GNRLFYLISE
60 70 80 90 100
DMTEPYEARR AEYHARYLDI QIVLKGQEGM TFSTQPAGAP DTDWLADKDI
110 120 130 140 150
AFLPEGVDEK TVILNEGDFV VFYPGEVHKP LCAVGAPAQV RKAVVKMLMA
Length:150
Mass (Da):16,865
Last modified:December 20, 2005 - v1
Checksum:i30E316B24C523DAE
GO

Sequence cautioni

The sequence AAA97148 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97148.1 Different initiation.
U00096 Genomic DNA Translation: AAC77209.2
AP009048 Genomic DNA Translation: BAE78249.1
PIRiS56477
RefSeqiNP_418673.4, NC_000913.3
WP_000583469.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77209; AAC77209; b4252
BAE78249; BAE78249; BAE78249
GeneIDi948777
KEGGiecj:JW5756
eco:b4252
PATRICifig|1411691.4.peg.2452

Similar proteinsi

Entry informationi

Entry nameiTABA_ECOLI
AccessioniPrimary (citable) accession number: P0AF96
Secondary accession number(s): P39335, Q2M657
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health