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Protein

Regulator of ribonuclease activity B

Gene

rraB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.UniRule annotation2 Publications

Miscellaneous

RraA and RraB interact with Rne at separate sites within the Rne and exert distinct effects on the composition of the degradosome, affecting distinct sets of RNA transcripts.

GO - Molecular functioni

  • endoribonuclease inhibitor activity Source: UniProtKB
  • enzyme binding Source: EcoCyc
  • ribonuclease inhibitor activity Source: EcoCyc

GO - Biological processi

  • mRNA catabolic process Source: EcoCyc
  • regulation of catalytic activity Source: EcoCyc
  • regulation of endoribonuclease activity Source: UniProtKB

Enzyme and pathway databases

BioCyciEcoCyc:G7885-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of ribonuclease activity BUniRule annotation
Gene namesi
Name:rraBUniRule annotation
Synonyms:yjgD
Ordered Locus Names:b4255, JW4212
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12453 rraB

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cytosol Source: EcoCyc

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001697591 – 138Regulator of ribonuclease activity BAdd BLAST138

Proteomic databases

PaxDbiP0AF90
PRIDEiP0AF90

Expressioni

Inductioni

Constitutively expressed. Expression is increased by a reduction in intracellular concentration of UDP-GlcNAc.1 Publication

Interactioni

Subunit structurei

Interacts with the C-terminal region of Rne.UniRule annotation1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: EcoCyc

Protein-protein interaction databases

BioGridi4263244, 13 interactors
DIPiDIP-47905N
IntActiP0AF90, 18 interactors
STRINGi316385.ECDH10B_4448

Structurei

3D structure databases

ProteinModelPortaliP0AF90
SMRiP0AF90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi116 – 134Asp/Glu-rich (acidic)Add BLAST19

Sequence similaritiesi

Belongs to the RraB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KQT Bacteria
COG3076 LUCA
HOGENOMiHOG000282487
KOiK09893
OMAiFCFDAIA

Family and domain databases

Gene3Di3.30.70.970, 1 hit
HAMAPiMF_01888 RraB, 1 hit
InterProiView protein in InterPro
IPR016716 RraB
IPR036701 RraB-like_sf
IPR009671 RraB_dom
PfamiView protein in Pfam
PF06877 RraB, 1 hit
PIRSFiPIRSF018193 UCP018193, 1 hit
SUPFAMiSSF89946 SSF89946, 1 hit

Sequencei

Sequence statusi: Complete.

P0AF90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPEQLEEQ REETRLIIEE LLEDGSDPDA LYTIEHHLSA DDLETLEKAA
60 70 80 90 100
VEAFKLGYEV TDPEELEVED GDIVICCDIL SECALNADLI DAQVEQLMTL
110 120 130
AEKFDVEYDG WGTYFEDPNG EDGDDEDFVD EDDDGVRH
Length:138
Mass (Da):15,603
Last modified:December 20, 2005 - v1
Checksum:iE23D6DBE6547FD0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97151.1
U00096 Genomic DNA Translation: AAC77212.1
AP009048 Genomic DNA Translation: BAE78252.1
M24186 Genomic DNA No translation available.
PIRiS56480
RefSeqiNP_418676.1, NC_000913.3
WP_000002953.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77212; AAC77212; b4255
BAE78252; BAE78252; BAE78252
GeneIDi948773
KEGGiecj:JW4212
eco:b4255
PATRICifig|1411691.4.peg.2449

Similar proteinsi

Entry informationi

Entry nameiRRAB_ECOLI
AccessioniPrimary (citable) accession number: P0AF90
Secondary accession number(s): P37163, Q2M654
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health