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Protein

HTH-type transcriptional repressor NsrR

Gene

nsrR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress, such as ytfE, hmpA and ygbA. May require iron for activity. Does not regulates its own transcription.1 Publication

Cofactori

[2Fe-2S] clusterCuratedNote: Binds 1 [2Fe-2S] cluster per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi91Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi96Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi102Iron-sulfur (2Fe-2S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 51H-T-H motifBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

2Fe-2S, DNA-binding, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11212-MONOMER.
ECOL316407:JW4136-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor NsrR
Gene namesi
Name:nsrR
Synonyms:yjeB
Ordered Locus Names:b4178, JW4136
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11212. nsrR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095551 – 141HTH-type transcriptional repressor NsrRAdd BLAST141

Proteomic databases

PaxDbiP0AF63.
PRIDEiP0AF63.

Interactioni

Protein-protein interaction databases

BioGridi4262026. 16 interactors.
DIPiDIP-48211N.
IntActiP0AF63. 1 interactor.
STRINGi511145.b4178.

Structurei

3D structure databases

ProteinModelPortaliP0AF63.
SMRiP0AF63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 129HTH rrf2-typeAdd BLAST128

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105KPV. Bacteria.
COG1959. LUCA.
HOGENOMiHOG000249814.
InParanoidiP0AF63.
KOiK13771.
OMAiLMKVIYR.
PhylomeDBiP0AF63.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01177. HTH_type_NsrR. 1 hit.
InterProiIPR030489. TR_Rrf2-type_CS.
IPR000944. Tscrpt_reg_Rrf2-type.
IPR023761. Tscrpt_rep_HTH_NsrR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02082. Rrf2. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
TIGRFAMsiTIGR00738. rrf2_super. 1 hit.
PROSITEiPS01332. HTH_RRF2_1. 1 hit.
PS51197. HTH_RRF2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AF63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLTSFTDYG LRALIYMASL PEGRMTSISE VTDVYGVSRN HMVKIINQLS
60 70 80 90 100
RAGYVTAVRG KNGGIRLGKP ASAIRIGDVV RELEPLSLVN CSSEFCHITP
110 120 130 140
ACRLKQALSK AVQSFLTELD NYTLADLVEE NQPLYKLLLV E
Length:141
Mass (Da):15,593
Last modified:December 20, 2005 - v1
Checksum:i6A783840023134D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04199 Genomic DNA. No translation available.
U14003 Genomic DNA. Translation: AAA97074.1.
U00096 Genomic DNA. Translation: AAC77135.1.
AP009048 Genomic DNA. Translation: BAE78179.1.
PIRiS56403.
RefSeqiNP_418599.1. NC_000913.3.
WP_001177639.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77135; AAC77135; b4178.
BAE78179; BAE78179; BAE78179.
GeneIDi948693.
KEGGiecj:JW4136.
eco:b4178.
PATRICi32123929. VBIEscCol129921_4309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04199 Genomic DNA. No translation available.
U14003 Genomic DNA. Translation: AAA97074.1.
U00096 Genomic DNA. Translation: AAC77135.1.
AP009048 Genomic DNA. Translation: BAE78179.1.
PIRiS56403.
RefSeqiNP_418599.1. NC_000913.3.
WP_001177639.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AF63.
SMRiP0AF63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262026. 16 interactors.
DIPiDIP-48211N.
IntActiP0AF63. 1 interactor.
STRINGi511145.b4178.

Proteomic databases

PaxDbiP0AF63.
PRIDEiP0AF63.

Protocols and materials databases

DNASUi948693.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77135; AAC77135; b4178.
BAE78179; BAE78179; BAE78179.
GeneIDi948693.
KEGGiecj:JW4136.
eco:b4178.
PATRICi32123929. VBIEscCol129921_4309.

Organism-specific databases

EchoBASEiEB1197.
EcoGeneiEG11212. nsrR.

Phylogenomic databases

eggNOGiENOG4105KPV. Bacteria.
COG1959. LUCA.
HOGENOMiHOG000249814.
InParanoidiP0AF63.
KOiK13771.
OMAiLMKVIYR.
PhylomeDBiP0AF63.

Enzyme and pathway databases

BioCyciEcoCyc:EG11212-MONOMER.
ECOL316407:JW4136-MONOMER.

Miscellaneous databases

PROiP0AF63.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01177. HTH_type_NsrR. 1 hit.
InterProiIPR030489. TR_Rrf2-type_CS.
IPR000944. Tscrpt_reg_Rrf2-type.
IPR023761. Tscrpt_rep_HTH_NsrR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02082. Rrf2. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
TIGRFAMsiTIGR00738. rrf2_super. 1 hit.
PROSITEiPS01332. HTH_RRF2_1. 1 hit.
PS51197. HTH_RRF2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNSRR_ECOLI
AccessioniPrimary (citable) accession number: P0AF63
Secondary accession number(s): P21498, P72442, Q2M6C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.