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Protein

N-acetylglucosamine repressor

Gene

nagC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi35 – 44H-T-H motifBy similarity10

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • carbohydrate metabolic process Source: UniProtKB-KW
  • regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Carbohydrate metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00266.
ECOL316407:JW0662-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosamine repressor
Gene namesi
Name:nagC
Synonyms:nagR
Ordered Locus Names:b0676, JW0662
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10636. nagC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000956911 – 406N-acetylglucosamine repressorAdd BLAST406

Proteomic databases

EPDiP0AF20.
PaxDbiP0AF20.
PRIDEiP0AF20.

Expressioni

Inductioni

By N-acetylglucosamine.

Interactioni

Protein-protein interaction databases

BioGridi4261210. 8 interactors.
DIPiDIP-35984N.
IntActiP0AF20. 9 interactors.
STRINGi511145.b0676.

Structurei

3D structure databases

ProteinModelPortaliP0AF20.
SMRiP0AF20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family.Curated

Phylogenomic databases

eggNOGiENOG4105E2R. Bacteria.
COG1940. LUCA.
HOGENOMiHOG000275182.
InParanoidiP0AF20.
KOiK02565.
OMAiHQRRIRE.
PhylomeDBiP0AF20.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR000600. ROK.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01047. MarR. 1 hit.
PF00480. ROK. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AF20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPGGQAQIG NVDLVKQLNS AAVYRLIDQY GPISRIQIAE QSQLAPASVT
60 70 80 90 100
KITRQLIERG LIKEVDQQAS TGGRRAISIV TETRNFHAIG VRLGRHDATI
110 120 130 140 150
TLFDLSSKVL AEEHYPLPER TQQTLEHALL NAIAQFIDSY QRKLRELIAI
160 170 180 190 200
SVILPGLVDP DSGKIHYMPH IQVENWGLVE ALEERFKVTC FVGHDIRSLA
210 220 230 240 250
LAEHYFGASQ DCEDSILVRV HRGTGAGIIS NGRIFIGRNG NVGEIGHIQV
260 270 280 290 300
EPLGERCHCG NFGCLETIAA NAAIEQRVLN LLKQGYQSRV PLDDCTIKTI
310 320 330 340 350
CKAANKGDSL ASEVIEYVGR HLGKTIAIAI NLFNPQKIVI AGEITEADKV
360 370 380 390 400
LLPAIESCIN TQALKAFRTN LPVVRSELDH RSAIGAFALV KRAMLNGILL

QHLLEN
Length:406
Mass (Da):44,541
Last modified:December 20, 2005 - v1
Checksum:i28C4C85D736627C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203 – 204EH → DD in CAA32354 (PubMed:2668691).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14135 Genomic DNA. Translation: CAA32354.1.
AF052007 Genomic DNA. Translation: AAC09326.1.
U00096 Genomic DNA. Translation: AAC73770.1.
AP009048 Genomic DNA. Translation: BAA35319.1.
PIRiC64802.
RefSeqiNP_415202.1. NC_000913.3.
WP_000187594.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73770; AAC73770; b0676.
BAA35319; BAA35319; BAA35319.
GeneIDi945285.
KEGGiecj:JW0662.
eco:b0676.
PATRICi32116537. VBIEscCol129921_0701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14135 Genomic DNA. Translation: CAA32354.1.
AF052007 Genomic DNA. Translation: AAC09326.1.
U00096 Genomic DNA. Translation: AAC73770.1.
AP009048 Genomic DNA. Translation: BAA35319.1.
PIRiC64802.
RefSeqiNP_415202.1. NC_000913.3.
WP_000187594.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AF20.
SMRiP0AF20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261210. 8 interactors.
DIPiDIP-35984N.
IntActiP0AF20. 9 interactors.
STRINGi511145.b0676.

Proteomic databases

EPDiP0AF20.
PaxDbiP0AF20.
PRIDEiP0AF20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73770; AAC73770; b0676.
BAA35319; BAA35319; BAA35319.
GeneIDi945285.
KEGGiecj:JW0662.
eco:b0676.
PATRICi32116537. VBIEscCol129921_0701.

Organism-specific databases

EchoBASEiEB0630.
EcoGeneiEG10636. nagC.

Phylogenomic databases

eggNOGiENOG4105E2R. Bacteria.
COG1940. LUCA.
HOGENOMiHOG000275182.
InParanoidiP0AF20.
KOiK02565.
OMAiHQRRIRE.
PhylomeDBiP0AF20.

Enzyme and pathway databases

BioCyciEcoCyc:PD00266.
ECOL316407:JW0662-MONOMER.

Miscellaneous databases

PROiP0AF20.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR000600. ROK.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01047. MarR. 1 hit.
PF00480. ROK. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAGC_ECOLI
AccessioniPrimary (citable) accession number: P0AF20
Secondary accession number(s): P15301
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.