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Protein

Iron-sulfur cluster carrier protein

Gene

mrp

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi115 – 1228ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10611-MONOMER.
ECOL316407:JW2100-MONOMER.
RETL1328306-WGS:GSTH-872-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur cluster carrier proteinUniRule annotation
Gene namesi
Name:mrp
Ordered Locus Names:b2113, JW2100
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10611. mrp.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Iron-sulfur cluster carrier proteinPRO_0000184932Add
BLAST

Proteomic databases

EPDiP0AF08.
PaxDbiP0AF08.
PRIDEiP0AF08.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

BioGridi4259514. 54 interactions.
IntActiP0AF08. 6 interactions.
STRINGi511145.b2113.

Structurei

3D structure databases

ProteinModelPortaliP0AF08.
SMRiP0AF08. Positions 106-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mrp/NBP35 ATP-binding proteins family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D1F. Bacteria.
COG0489. LUCA.
HOGENOMiHOG000079914.
InParanoidiP0AF08.
KOiK03593.
OMAiTMPFVWL.
PhylomeDBiP0AF08.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02040. Mrp_NBP35. 1 hit.
InterProiIPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AF08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEQSQAKSP EALRAMVAGT LANFQHPTLK HNLTTLKALH HVAWMDDTLH
60 70 80 90 100
VELVMPFVWH SAFEELKEQC SAELLRITGA KAIDWKLSHN IATLKRVKNQ
110 120 130 140 150
PGINGVKNII AVSSGKGGVG KSSTAVNLAL ALAAEGAKVG ILDADIYGPS
160 170 180 190 200
IPTMLGAENQ RPTSPDGTHM APIMSHGLAT NSIGYLVTDD NAMVWRGPMA
210 220 230 240 250
SKALMQMLQE TLWPDLDYLV LDMPPGTGDI QLTLAQNIPV TGAVVVTTPQ
260 270 280 290 300
DIALIDAKKG IVMFEKVEVP VLGIVENMSV HICSNCGHHE PIFGTGGAEK
310 320 330 340 350
LAEKYHTQLL GQMPLHISLR EDLDKGTPTV ISRPESEFTA IYRQLADRVA
360
AQLYWQGEVI PGEISFRAV
Length:369
Mass (Da):39,938
Last modified:December 20, 2005 - v1
Checksum:iF3437F3A6408042E
GO

Sequence cautioni

The sequence AAA60527 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60527.1. Different initiation.
X55791 Genomic DNA. Translation: CAA39316.1.
U00096 Genomic DNA. Translation: AAC75174.2.
AP009048 Genomic DNA. Translation: BAE76591.1.
RefSeqiNP_416616.4. NC_000913.3.
WP_001005448.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75174; AAC75174; b2113.
BAE76591; BAE76591; BAE76591.
GeneIDi946627.
KEGGiecj:JW2100.
eco:b2113.
PATRICi32119559. VBIEscCol129921_2190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA. Translation: AAA60527.1. Different initiation.
X55791 Genomic DNA. Translation: CAA39316.1.
U00096 Genomic DNA. Translation: AAC75174.2.
AP009048 Genomic DNA. Translation: BAE76591.1.
RefSeqiNP_416616.4. NC_000913.3.
WP_001005448.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AF08.
SMRiP0AF08. Positions 106-326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259514. 54 interactions.
IntActiP0AF08. 6 interactions.
STRINGi511145.b2113.

Proteomic databases

EPDiP0AF08.
PaxDbiP0AF08.
PRIDEiP0AF08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75174; AAC75174; b2113.
BAE76591; BAE76591; BAE76591.
GeneIDi946627.
KEGGiecj:JW2100.
eco:b2113.
PATRICi32119559. VBIEscCol129921_2190.

Organism-specific databases

EchoBASEiEB0606.
EcoGeneiEG10611. mrp.

Phylogenomic databases

eggNOGiENOG4105D1F. Bacteria.
COG0489. LUCA.
HOGENOMiHOG000079914.
InParanoidiP0AF08.
KOiK03593.
OMAiTMPFVWL.
PhylomeDBiP0AF08.

Enzyme and pathway databases

BioCyciEcoCyc:EG10611-MONOMER.
ECOL316407:JW2100-MONOMER.
RETL1328306-WGS:GSTH-872-MONOMER.

Miscellaneous databases

PROiP0AF08.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02040. Mrp_NBP35. 1 hit.
InterProiIPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPBC_ECOLI
AccessioniPrimary (citable) accession number: P0AF08
Secondary accession number(s): P21590, Q2MAW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.