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Protein

Iron-sulfur cluster carrier protein

Gene

mrp

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi115 – 122ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10611-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur cluster carrier proteinUniRule annotation
Gene namesi
Name:mrp
Ordered Locus Names:b2113, JW2100
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10611 mrp

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001849321 – 369Iron-sulfur cluster carrier proteinAdd BLAST369

Proteomic databases

EPDiP0AF08
PaxDbiP0AF08
PRIDEiP0AF08

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

BioGridi4259514, 62 interactors
IntActiP0AF08, 6 interactors
STRINGi316385.ECDH10B_2266

Structurei

3D structure databases

ProteinModelPortaliP0AF08
SMRiP0AF08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mrp/NBP35 ATP-binding proteins family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D1F Bacteria
COG0489 LUCA
HOGENOMiHOG000079914
InParanoidiP0AF08
KOiK03593
OMAiPMLNGII
PhylomeDBiP0AF08

Family and domain databases

CDDicd02037 MRP-like, 1 hit
HAMAPiMF_02040 Mrp_NBP35, 1 hit
InterProiView protein in InterPro
IPR034904 FSCA_dom_sf
IPR019591 Mrp/NBP35_ATP-bd
IPR000808 Mrp_CS
IPR027417 P-loop_NTPase
IPR033756 YlxH/NBP35
PfamiView protein in Pfam
PF10609 ParA, 1 hit
SUPFAMiSSF117916 SSF117916, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS01215 MRP, 1 hit

Sequencei

Sequence statusi: Complete.

P0AF08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEQSQAKSP EALRAMVAGT LANFQHPTLK HNLTTLKALH HVAWMDDTLH
60 70 80 90 100
VELVMPFVWH SAFEELKEQC SAELLRITGA KAIDWKLSHN IATLKRVKNQ
110 120 130 140 150
PGINGVKNII AVSSGKGGVG KSSTAVNLAL ALAAEGAKVG ILDADIYGPS
160 170 180 190 200
IPTMLGAENQ RPTSPDGTHM APIMSHGLAT NSIGYLVTDD NAMVWRGPMA
210 220 230 240 250
SKALMQMLQE TLWPDLDYLV LDMPPGTGDI QLTLAQNIPV TGAVVVTTPQ
260 270 280 290 300
DIALIDAKKG IVMFEKVEVP VLGIVENMSV HICSNCGHHE PIFGTGGAEK
310 320 330 340 350
LAEKYHTQLL GQMPLHISLR EDLDKGTPTV ISRPESEFTA IYRQLADRVA
360
AQLYWQGEVI PGEISFRAV
Length:369
Mass (Da):39,938
Last modified:December 20, 2005 - v1
Checksum:iF3437F3A6408042E
GO

Sequence cautioni

The sequence AAA60527 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00007 Genomic DNA Translation: AAA60527.1 Different initiation.
X55791 Genomic DNA Translation: CAA39316.1
U00096 Genomic DNA Translation: AAC75174.2
AP009048 Genomic DNA Translation: BAE76591.1
RefSeqiNP_416616.4, NC_000913.3
WP_001005448.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75174; AAC75174; b2113
BAE76591; BAE76591; BAE76591
GeneIDi946627
KEGGiecj:JW2100
eco:b2113
PATRICifig|1411691.4.peg.134

Similar proteinsi

Entry informationi

Entry nameiAPBC_ECOLI
AccessioniPrimary (citable) accession number: P0AF08
Secondary accession number(s): P21590, Q2MAW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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