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Protein

Molybdenum transport system permease protein ModB

Gene

modB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Molybdenum

Enzyme and pathway databases

BioCyciEcoCyc:MODB-MONOMER.
ECOL316407:JW0747-MONOMER.
MetaCyc:MODB-MONOMER.
RETL1328306-WGS:GSTH-4184-MONOMER.

Protein family/group databases

TCDBi3.A.1.8.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdenum transport system permease protein ModB
Gene namesi
Name:modB
Synonyms:chlJ
Ordered Locus Names:b0764, JW0747
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10002. modB.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616PeriplasmicSequence analysisAdd
BLAST
Transmembranei17 – 3721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini38 – 4912CytoplasmicSequence analysisAdd
BLAST
Transmembranei50 – 7021HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini71 – 8313PeriplasmicSequence analysisAdd
BLAST
Transmembranei84 – 10421HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini105 – 13632CytoplasmicSequence analysisAdd
BLAST
Transmembranei137 – 15721HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini158 – 20144PeriplasmicSequence analysisAdd
BLAST
Transmembranei202 – 22221HelicalPROSITE-ProRule annotationAdd
BLAST
Topological domaini223 – 2297CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Molybdenum transport system permease protein ModBPRO_0000060111Add
BLAST

Proteomic databases

PaxDbiP0AF01.

Interactioni

Protein-protein interaction databases

BioGridi4261270. 7 interactions.
IntActiP0AF01. 4 interactions.
STRINGi511145.b0764.

Structurei

3D structure databases

ProteinModelPortaliP0AF01.
SMRiP0AF01. Positions 4-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 219209ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105E0C. Bacteria.
COG4149. LUCA.
HOGENOMiHOG000263699.
InParanoidiP0AF01.
KOiK02018.
OMAiTPGAEME.
OrthoDBiEOG6T7N3V.
PhylomeDBiP0AF01.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR011867. ModB_ABC.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR02141. modB_ABC. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0AF01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILTDPEWQA VLLSLKVSSL AVLFSLPFGI FFAWLLVRCT FPGKALLDSV
60 70 80 90 100
LHLPLVLPPV VVGYLLLVSM GRRGFIGERL YDWFGITFAF SWRGAVLAAA
110 120 130 140 150
VMSFPLMVRA IRLALEGVDV KLEQAARTLG AGRWRVFFTI TLPLTLPGII
160 170 180 190 200
VGTVLAFARS LGEFGATITF VSNIPGETRT IPSAMYTLIQ TPGGESGAAR
210 220
LCIISIALAM ISLLISEWLA RISRERAGR
Length:229
Mass (Da):24,939
Last modified:December 20, 2005 - v1
Checksum:i65A3A05FBF3382C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401T → S (PubMed:7665460).Curated
Sequence conflicti40 – 401T → S (PubMed:8564363).Curated
Sequence conflicti40 – 401T → S (PubMed:3553151).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34009 Genomic DNA. Translation: AAB00836.1.
U27192 Genomic DNA. Translation: AAB60172.1.
U07867 Genomic DNA. Translation: AAB06894.1.
U00096 Genomic DNA. Translation: AAC73851.1.
AP009048 Genomic DNA. Translation: BAA35428.1.
M16182 Genomic DNA. Translation: AAA83839.1.
PIRiD64812. BVECHJ.
RefSeqiNP_415285.1. NC_000913.3.
WP_000604034.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73851; AAC73851; b0764.
BAA35428; BAA35428; BAA35428.
GeneIDi945361.
KEGGiecj:JW0747.
eco:b0764.
PATRICi32116729. VBIEscCol129921_0790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34009 Genomic DNA. Translation: AAB00836.1.
U27192 Genomic DNA. Translation: AAB60172.1.
U07867 Genomic DNA. Translation: AAB06894.1.
U00096 Genomic DNA. Translation: AAC73851.1.
AP009048 Genomic DNA. Translation: BAA35428.1.
M16182 Genomic DNA. Translation: AAA83839.1.
PIRiD64812. BVECHJ.
RefSeqiNP_415285.1. NC_000913.3.
WP_000604034.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP0AF01.
SMRiP0AF01. Positions 4-219.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261270. 7 interactions.
IntActiP0AF01. 4 interactions.
STRINGi511145.b0764.

Protein family/group databases

TCDBi3.A.1.8.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0AF01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73851; AAC73851; b0764.
BAA35428; BAA35428; BAA35428.
GeneIDi945361.
KEGGiecj:JW0747.
eco:b0764.
PATRICi32116729. VBIEscCol129921_0790.

Organism-specific databases

EchoBASEiEB0002.
EcoGeneiEG10002. modB.

Phylogenomic databases

eggNOGiENOG4105E0C. Bacteria.
COG4149. LUCA.
HOGENOMiHOG000263699.
InParanoidiP0AF01.
KOiK02018.
OMAiTPGAEME.
OrthoDBiEOG6T7N3V.
PhylomeDBiP0AF01.

Enzyme and pathway databases

BioCyciEcoCyc:MODB-MONOMER.
ECOL316407:JW0747-MONOMER.
MetaCyc:MODB-MONOMER.
RETL1328306-WGS:GSTH-4184-MONOMER.

Miscellaneous databases

PROiP0AF01.

Family and domain databases

Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
IPR011867. ModB_ABC.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR02141. modB_ABC. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic analysis of the modABCD (molybdate transport) operon of Escherichia coli."
    Maupin-Furlow J.A., Rosentel J.K., Lee J.H., Deppenmeier U., Gunsalus R.P., Shanmugam K.T.
    J. Bacteriol. 177:4851-4856(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Molecular analysis of the molybdate uptake operon, modABCD, of Escherichia coli and modR, a regulatory gene."
    Walkenhorst H.M., Hemschemeier S.K., Eichenlaub R.
    Microbiol. Res. 150:347-361(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / MC1000 / ATCC 39531.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Cloning and nucleotide sequence of the chlD locus."
    Johann S., Hinton S.M.
    J. Bacteriol. 169:1911-1916(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 30-229.
    Strain: K12.
  7. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiMODB_ECOLI
AccessioniPrimary (citable) accession number: P0AF01
Secondary accession number(s): P09834, P77537
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 20, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.