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Protein

Septum site-determining protein MinD

Gene

minD

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciECOL386585:GJFA-1651-MONOMER.
ECOO157:MIND-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Septum site-determining protein MinD
Alternative name(s):
Cell division inhibitor MinD
Gene namesi
Name:minD
Ordered Locus Names:Z1937, ECs1669
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 270269Septum site-determining protein MinDPRO_0000201969Add
BLAST

Proteomic databases

PRIDEiP0AEZ5.

Interactioni

Subunit structurei

Interacts with MinC and FtsZ.By similarity

Protein-protein interaction databases

MINTiMINT-137071.
STRINGi155864.Z1937.

Structurei

3D structure databases

ProteinModelPortaliP0AEZ5.
SMRiP0AEZ5. Positions 2-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ParA family. MinD subfamily.Curated

Phylogenomic databases

eggNOGiENOG4107QMS. Bacteria.
COG2894. LUCA.
HOGENOMiHOG000019419.
KOiK03609.
OMAiVNRIRNH.
OrthoDBiEOG6NPMB6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR025501. MinD.
IPR010223. MinD_bac-type.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01656. CbiA. 1 hit.
[Graphical view]
PIRSFiPIRSF003092. MinD. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01968. minD_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0AEZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARIIVVTSG KGGVGKTTSS AAIATGLAQK GKKTVVIDFD IGLRNLDLIM
60 70 80 90 100
GCERRVVYDF VNVIQGDATL NQALIKDKRT ENLYILPASQ TRDKDALTRE
110 120 130 140 150
GVAKVLDDLK AMDFEFIVCD SPAGIETGAL MALYFADEAI ITTNPEVSSV
160 170 180 190 200
RDSDRILGIL ASKSRRAENG EEPIKEHLLL TRYNPGRVSR GDMLSMEDVL
210 220 230 240 250
EILRIKLVGV IPEDQSVLRA SNQGEPVILD INADAGKAYA DTVERLLGEE
260 270
RPFRFIEEEK KGFLKRLFGG
Length:270
Mass (Da):29,614
Last modified:January 23, 2007 - v2
Checksum:i0D2C4C0976B77D2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG56026.1.
BA000007 Genomic DNA. Translation: BAB35092.1.
PIRiE90837.
F85695.
RefSeqiNP_309696.1. NC_002695.1.
WP_000101055.1. NZ_LPWC01000205.1.

Genome annotation databases

EnsemblBacteriaiAAG56026; AAG56026; Z1937.
BAB35092; BAB35092; BAB35092.
GeneIDi913204.
KEGGiece:Z1937.
ecs:ECs1669.
PATRICi18352588. VBIEscCol44059_1519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005174 Genomic DNA. Translation: AAG56026.1.
BA000007 Genomic DNA. Translation: BAB35092.1.
PIRiE90837.
F85695.
RefSeqiNP_309696.1. NC_002695.1.
WP_000101055.1. NZ_LPWC01000205.1.

3D structure databases

ProteinModelPortaliP0AEZ5.
SMRiP0AEZ5. Positions 2-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-137071.
STRINGi155864.Z1937.

Proteomic databases

PRIDEiP0AEZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG56026; AAG56026; Z1937.
BAB35092; BAB35092; BAB35092.
GeneIDi913204.
KEGGiece:Z1937.
ecs:ECs1669.
PATRICi18352588. VBIEscCol44059_1519.

Phylogenomic databases

eggNOGiENOG4107QMS. Bacteria.
COG2894. LUCA.
HOGENOMiHOG000019419.
KOiK03609.
OMAiVNRIRNH.
OrthoDBiEOG6NPMB6.

Enzyme and pathway databases

BioCyciECOL386585:GJFA-1651-MONOMER.
ECOO157:MIND-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR025501. MinD.
IPR010223. MinD_bac-type.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01656. CbiA. 1 hit.
[Graphical view]
PIRSFiPIRSF003092. MinD. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01968. minD_bact. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / EDL933 / ATCC 700927 / EHEC.
  2. "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12."
    Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K., Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.
    , Kuhara S., Shiba T., Hattori M., Shinagawa H.
    DNA Res. 8:11-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: O157:H7 / Sakai / RIMD 0509952 / EHEC.

Entry informationi

Entry nameiMIND_ECO57
AccessioniPrimary (citable) accession number: P0AEZ5
Secondary accession number(s): P18197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.