P0AEY5 (MDAB_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Modulator of drug activity B

Gene names

Name:	mdaB
Synonyms:	mda66
Ordered Locus Names:	b3028, JW2996

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

To H.influenzae HI_0648 and S.pombe SPAC5H10.05c.

Ontologies

Keywords
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	NADPH dehydrogenase (quinone) activity Inferred from direct assay PubMed 8611590. Source: EcoCyc flavin adenine dinucleotide binding Inferred from direct assay PubMed 16630630. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 193

193

Modulator of drug activity B

PRO_0000096312

Secondary structure

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193

Helix Strand Turn

Details...

Beta strand

3 – 8

6

Helix

19 – 34

16

Beta strand

38 – 46

9

Helix

50 – 59

10

Beta strand

61 – 68

8

Helix

76 – 88

13

Turn

89 – 92

4

Beta strand

93 – 98

6

Beta strand

118 – 124

7

Helix

130 – 133

4

Turn

138 – 141

4

Helix

144 – 147

4

Helix

149 – 157

9

Beta strand

166 – 168

3

Turn

171 – 173

3

Turn

177 – 179

3

Helix

180 – 192

13

Sequences

	Sequence		Length	Mass (Da)
	P0AEY5 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: FEE3B4D13C2733CA	FASTA	193	21,891
	10 20 30 40 50 60 MSNILIINGA KKFAHSNGQL NDTLTEVADG TLRDLGHDVR IVRADSDYDV KAEVQNFLWA 70 80 90 100 110 120 DVVIWQMPGW WMGAPWTVKK YIDDVFTEGH GTLYASDGRT RKDPSKKYGS GGLVQGKKYM 130 140 150 160 170 180 LSLTWNAPME AFTEKDQFFH GVGVDGVYLP FHKANQFLGM EPLPTFIAND VIKMPDVPRY 190 TEEYRKHLVE IFG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A general genetic approach in Escherichia coli for determining the mechanism(s) of action of tumoricidal agents: application to DMP 840, a tumoricidal agent." Chatterjee P.K., Sternberg N.L. Proc. Natl. Acad. Sci. U.S.A. 92:8950-8954(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U18656 Genomic DNA. Translation: AAC43451.1.
U28377 Genomic DNA. Translation: AAA69196.1.
U00096 Genomic DNA. Translation: AAC76064.1.
AP009048 Genomic DNA. Translation: BAE77084.1.

PIR

I80319.

RefSeq

NP_417500.1. NC_000913.2.
YP_491220.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2B3D	X-ray	2.10	A/B	2-193	[»]

ProteinModelPortal

P0AEY5.

SMR

P0AEY5. Positions 2-193.

ModBase

Search...

Protein-protein interaction databases

IntAct

P0AEY5. 2 interactions.

STRING

511145.b3028.

Proteomic databases

PaxDb

P0AEY5.

PRIDE

P0AEY5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC76064; AAC76064; b3028.
BAE77084; BAE77084; BAE77084.

GeneID

12934040.
947512.

KEGG

ecj:Y75_p2954.
eco:b3028.

PATRIC

32121466. VBIEscCol129921_3120.

Organism-specific databases

EchoBASE

EB2524.

EcoGene

EG12656. mdaB.

Phylogenomic databases

eggNOG

COG2249.

HOGENOM

HOG000063966.

KO

K03923.

OMA

PTFICND.

ProtClustDB

CLSK880554.

Enzyme and pathway databases

BioCyc

EcoCyc:EG12656-MONOMER.
ECOL316407:JW2996-MONOMER.
MetaCyc:EG12656-MONOMER.

Gene expression databases

Genevestigator

P0AEY5.

Family and domain databases

InterPro

IPR003680. Flavodoxin_fold.
[Graphical view]

Pfam

PF02525. Flavodoxin_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P0AEY5.

Entry information

Entry name

MDAB_ECOLI

Accession

Primary (citable) accession number: P0AEY5
Secondary accession number(s): P40717, Q2M9H2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program