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Protein

Modulator of drug activity B

Gene

mdaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: EcoCyc
  • NADPH dehydrogenase (quinone) activity Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:EG12656-MONOMER.
ECOL316407:JW2996-MONOMER.
MetaCyc:EG12656-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator of drug activity B
Gene namesi
Name:mdaB
Synonyms:mda66
Ordered Locus Names:b3028, JW2996
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12656. mdaB.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Modulator of drug activity BPRO_0000096312Add
BLAST

Proteomic databases

PaxDbiP0AEY5.
PRIDEiP0AEY5.

Interactioni

Protein-protein interaction databases

BioGridi4263034. 19 interactions.
IntActiP0AEY5. 3 interactions.
STRINGi511145.b3028.

Structurei

Secondary structure

1
193
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Helixi19 – 3416Combined sources
Beta strandi38 – 469Combined sources
Helixi50 – 5910Combined sources
Beta strandi61 – 688Combined sources
Helixi76 – 8813Combined sources
Turni89 – 924Combined sources
Beta strandi93 – 986Combined sources
Beta strandi118 – 1247Combined sources
Helixi130 – 1334Combined sources
Turni138 – 1414Combined sources
Helixi144 – 1474Combined sources
Helixi149 – 1579Combined sources
Beta strandi166 – 1683Combined sources
Turni171 – 1733Combined sources
Turni177 – 1793Combined sources
Helixi180 – 19213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B3DX-ray2.10A/B2-193[»]
ProteinModelPortaliP0AEY5.
SMRiP0AEY5. Positions 2-193.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0AEY5.

Family & Domainsi

Sequence similaritiesi

To H.influenzae HI_0648 and S.pombe SPAC5H10.05c.Curated

Phylogenomic databases

eggNOGiENOG4105NF4. Bacteria.
COG2249. LUCA.
HOGENOMiHOG000063966.
InParanoidiP0AEY5.
KOiK03923.
OMAiPTFICND.
OrthoDBiEOG6ZWJFM.
PhylomeDBiP0AEY5.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.

Sequencei

Sequence statusi: Complete.

P0AEY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNILIINGA KKFAHSNGQL NDTLTEVADG TLRDLGHDVR IVRADSDYDV
60 70 80 90 100
KAEVQNFLWA DVVIWQMPGW WMGAPWTVKK YIDDVFTEGH GTLYASDGRT
110 120 130 140 150
RKDPSKKYGS GGLVQGKKYM LSLTWNAPME AFTEKDQFFH GVGVDGVYLP
160 170 180 190
FHKANQFLGM EPLPTFIAND VIKMPDVPRY TEEYRKHLVE IFG
Length:193
Mass (Da):21,891
Last modified:December 20, 2005 - v1
Checksum:iFEE3B4D13C2733CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18656 Genomic DNA. Translation: AAC43451.1.
U28377 Genomic DNA. Translation: AAA69196.1.
U00096 Genomic DNA. Translation: AAC76064.1.
AP009048 Genomic DNA. Translation: BAE77084.1.
PIRiI80319.
RefSeqiNP_417500.1. NC_000913.3.
WP_000065430.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76064; AAC76064; b3028.
BAE77084; BAE77084; BAE77084.
GeneIDi947512.
KEGGiecj:JW2996.
eco:b3028.
PATRICi32121466. VBIEscCol129921_3120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18656 Genomic DNA. Translation: AAC43451.1.
U28377 Genomic DNA. Translation: AAA69196.1.
U00096 Genomic DNA. Translation: AAC76064.1.
AP009048 Genomic DNA. Translation: BAE77084.1.
PIRiI80319.
RefSeqiNP_417500.1. NC_000913.3.
WP_000065430.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B3DX-ray2.10A/B2-193[»]
ProteinModelPortaliP0AEY5.
SMRiP0AEY5. Positions 2-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263034. 19 interactions.
IntActiP0AEY5. 3 interactions.
STRINGi511145.b3028.

Proteomic databases

PaxDbiP0AEY5.
PRIDEiP0AEY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76064; AAC76064; b3028.
BAE77084; BAE77084; BAE77084.
GeneIDi947512.
KEGGiecj:JW2996.
eco:b3028.
PATRICi32121466. VBIEscCol129921_3120.

Organism-specific databases

EchoBASEiEB2524.
EcoGeneiEG12656. mdaB.

Phylogenomic databases

eggNOGiENOG4105NF4. Bacteria.
COG2249. LUCA.
HOGENOMiHOG000063966.
InParanoidiP0AEY5.
KOiK03923.
OMAiPTFICND.
OrthoDBiEOG6ZWJFM.
PhylomeDBiP0AEY5.

Enzyme and pathway databases

BioCyciEcoCyc:EG12656-MONOMER.
ECOL316407:JW2996-MONOMER.
MetaCyc:EG12656-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0AEY5.
PROiP0AEY5.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR003680. Flavodoxin_fold.
IPR029039. Flavoprotein-like_dom.
[Graphical view]
PfamiPF02525. Flavodoxin_2. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A general genetic approach in Escherichia coli for determining the mechanism(s) of action of tumoricidal agents: application to DMP 840, a tumoricidal agent."
    Chatterjee P.K., Sternberg N.L.
    Proc. Natl. Acad. Sci. U.S.A. 92:8950-8954(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiMDAB_ECOLI
AccessioniPrimary (citable) accession number: P0AEY5
Secondary accession number(s): P40717, Q2M9H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: July 6, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.